Detalhe da pesquisa
1.
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry
; 29(29): e202203868, 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36912255
2.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
Angew Chem Int Ed Engl
; 62(17): e202300221, 2023 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757665
3.
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Nucleic Acids Res
; 48(14): 8099-8112, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32602532
4.
Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).
Bioorg Med Chem Lett
; 30(2): 126792, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757668
5.
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.
Biochem J
; 476(21): 3125-3139, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488574
6.
meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation.
Chemistry
; 25(34): 8018-8023, 2019 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30974007
7.
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
Philos Trans A Math Phys Eng Sci
; 377(2147): 20180422, 2019 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31030650
8.
Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.
Adv Exp Med Biol
; 1163: 253-278, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31707707
9.
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
J Biol Chem
; 292(4): 1310-1329, 2017 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27932461
10.
Fragment-based approaches to TB drugs.
Parasitology
; 145(2): 184-195, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27804891
11.
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
Biochemistry
; 56(11): 1559-1572, 2017 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28169518
12.
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
Anal Chem
; 89(18): 9976-9983, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28803470
13.
Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.
Angew Chem Int Ed Engl
; 56(26): 7488-7491, 2017 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28513917
14.
Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.
Bioorg Med Chem Lett
; 26(15): 3735-40, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27287372
15.
Organic synthesis reactions on-water at the organic-liquid water interface.
Org Biomol Chem
; 14(42): 9945-9960, 2016 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27714194
16.
Understanding "on-water" catalysis of organic reactions. Effects of H+ and Li+ ions in the aqueous phase and nonreacting competitor H-bond acceptors in the organic phase: on H2O versus on D2O for Huisgen cycloadditions.
J Org Chem
; 80(3): 1809-17, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25621921
17.
Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation.
Chemistry
; 20(37): 11680-4, 2014 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25048717
18.
Water and organic synthesis: a focus on the in-water and on-water border. Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on-water conditions for Huisgen cycloadditions with increasingly insoluble organic liquid and solid 2π-dipolarophiles.
J Org Chem
; 78(7): 3276-91, 2013 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23463988
19.
Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
ChemMedChem
; 18(15): e202300240, 2023 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37195570
20.
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
Int J Parasitol Drugs Drug Resist
; 22: 1-8, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37004488