Detalhe da pesquisa
1.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
2.
Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).
ACS Infect Dis
; 9(3): 527-539, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36763526
3.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
ChemMedChem
; 17(22): e202200393, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129427
4.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
J Med Chem
; 65(5): 3798-3813, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229610
5.
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362.
J Med Chem
; 65(20): 14121-14143, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216349
6.
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
J Med Chem
; 58(11): 4573-80, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25906200