Multicentric prevalence study of anti P ribosomal autoantibodies in juvenile onset systemic lupus erythematosus compared with adult onset systemic lupus erythematosus.

OBJECTIVE: To investigate the prevalence and associations with clinical manifestations of anti- P ribosomal antibodies in patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). METHODS: Clinical and serological data of 30 patients with juvenile-onset SLE (age at onset younger than 16 years old) were compared with data of 92 patients with adult-onset SLE. Symptoms occurring during the entire disease course were considered. Anti- P ribosomal antibodies were tested by ELISA. RESULTS: Anti- P ribosomal antibodies were found significantly more often in pediatric-onset SLE patients (26.7% vs. 6.5%; OR=5.21 [CI95%=1.6-16.5], p=0.003). Alopecia (OR=10.11, CI 95%=1.25-97) and skin rash (non discoid) (OR=4.1, CI 95%=1.25-13.89) were significantly associated with anti- P ribosomal antibodies. CONCLUSION: Anti-ribosomal P antibodies are more often found in patients with juvenile SLE. Alopecia and skin rash were the only clinical manifestations associated to anti-ribosomal P antibodies.

Impacto da separação sobre a qualidade de vida de crianças em idade escolar / Impact of divorce on the quality of life in school-age children

OBJETIVO: Avaliar a qualidade de vida psicossocial em filhos de pais separados em idade escolar. MÉTODOS: Conduziu-se um estudo transversal no ambulatório pediátrico de um hospital comunitário. Foram incluídas crianças de 5 a 12 anos de idade, de famílias intactas e de famílias separadas. A qualidade de vida das crianças foi avaliada através de relatórios maternos, utilizando-se o Child Health Questionnaire - Parent Form 50. Um modelo de regressão linear múltipla foi construído incluindo variáveis clinicamente relevantes significativas para a análise univariada (coeficiente beta e IC de 95 por cento). RESULTADOS: Trezentas e trinta famílias foram convidadas a participar e 313 preencheram o questionário. A análise univariada demonstrou que a qualidade de vida estava significativamente associada à separação parental, sexo da criança, tempo passado com o pai, padrão de vida e nível de instrução materno. Em um modelo de regressão linear múltipla, os escores de qualidade de vida se mostraram mais baixos em meninos -4,5 (-6,8 a -2,3) e mais altos para tempo passado com o pai 0,09 (0,01 a 0,2). Em famílias separadas, a regressão demonstrou que os escores de qualidade de vida foram maiores quando a separação dos pais ocorrera em acordo mútuo 6,1 (2,7 a 9,4), quando a mãe possuía nível universitário 5,9 (1,7 a 10,1) e para cada ano passado desde a separação 0,6 (0,2 a 1,1), enquanto os escores foram menores em meninos -5,4 (-9,5 a -1,3) e para cada incremento de um ano da idade materna -0,4 (-0,7 a -0,05). CONCLUSÃO: A qualidade de vida psicossocial das crianças foi afetada pela separação. O Child Health Questionnaire pode ser útil para detectar um declínio na qualidade de vida psicossocial.

OBJECTIVE: To assess psychosocial quality of life in school-age children of divorced parents. METHODS: A cross-sectional survey was conducted at the pediatric outpatient clinic of a community hospital. Children 5 to 12 years old from married families and divorced families were included. Child quality of life was assessed through maternal reports using a Child Health Questionnaire - Parent Form 50. A multiple linear regression model was constructed including clinically relevant variables significant on univariate analysis (beta coefficient and 95 percentCI). RESULTS: Three hundred and thirty families were invited to participate and 313 completed the questionnaire. Univariate analysis showed that quality of life was significantly associated with parental separation, child sex, time spent with the father, standard of living, and maternal education. In a multiple linear regression model, quality of life scores decreased in boys -4.5 (-6.8 to -2.3) and increased for time spent with the father 0.09 (0.01 to 0.2). In divorced families, multiple linear regression showed that quality of life scores increased when parents had separated by mutual agreement 6.1 (2.7 to 9.4), when the mother had university level education 5.9 (1.7 to 10.1) and for each year elapsed since separation 0.6 (0.2 to 1.1), whereas scores decreased in boys -5.4 (-9.5 to -1.3) and for each one-year increment of maternal age -0.4 (-0.7 to -0.05). CONCLUSION: Childrens psychosocial quality of life was affected by divorce. The Child Health Questionnaire can be useful to detect a decline in the psychosocial quality of life.