Detalhe da pesquisa
1.
Legumain Functions as a Transient TrkB Sheddase.
Int J Mol Sci
; 24(6)2023 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982466
2.
Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition.
J Biol Chem
; 295(37): 13047-13064, 2020 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719006
3.
ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease.
Anal Chem
; 92(4): 2961-2971, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31951383
4.
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
J Biol Chem
; 293(34): 13151-13165, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29967063
5.
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc Natl Acad Sci U S A
; 113(40): 11196-11201, 2016 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27647913
6.
X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry
; 57(6): 925-934, 2018 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29314830
7.
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 3): 494-504, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25760599
8.
Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.
Chembiochem
; 16(17): 2441-4, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26426719
9.
Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain.
J Struct Biol
; 187(1): 30-37, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24859793
10.
Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
ChemMedChem
; 19(9): e202400057, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38385828
11.
Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 2): 284-97, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23385464
12.
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Proc Natl Acad Sci U S A
; 107(12): 5381-6, 2010 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20212142
13.
Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
ACS Chem Biol
; 17(4): 816-821, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35377598
14.
OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
ACS Chem Biol
; 16(9): 1692-1700, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34415722
15.
The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities.
ACS Catal
; 11(19): 11885-11896, 2021 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34621593
16.
The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.
ACS Med Chem Lett
; 12(3): 426-432, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33732412
17.
Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.
J Thromb Haemost
; 17(3): 470-481, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30644641
18.
Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.
ChemMedChem
; 14(6): 673-685, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30680958
19.
Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem Biol
; 12(5): 1211-1216, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28402100
20.
Optimization of Substrate-Analogue Furin Inhibitors.
ChemMedChem
; 12(23): 1953-1968, 2017 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29059503