RESUMO
BACKGROUND: Leishmaniasis and melioidosis are frequently reported from the North Central Province of Sri Lanka. However, only one case of co-infection of the two diseases has been reported to date over the world. This is a case report of a patient who had co-infection with cutaneous leishmaniasis and melioidosis and was successfully treated and recovered from the illness. CASE PRESENTATION: A 61 year old female patient with diabetes mellitus presented with fever for one month's duration and was found to have hepatosplenomegaly and an ulcer over the left arm. She had elevated inflammatory markers and blood culture grew Burkholderia pseudomallei and serum was highly positive for melioidosis antibodies. A slit skin smear of the ulcer showed Leishmania amastigotes. CONCLUSION: Melioidosis and leishmaniasis are emerging infectious diseases in endemic countries and can be severe. The high prevalence rates in Sri Lanka should keep the treating physicians' threshold for suspicion low for these two diseases.
Assuntos
Leishmaniose Cutânea/etiologia , Melioidose/etiologia , Abscesso Abdominal/tratamento farmacológico , Burkholderia pseudomallei/isolamento & purificação , Ceftazidima/uso terapêutico , Coinfecção , Feminino , Humanos , Leishmania/patogenicidade , Leishmaniose Cutânea/tratamento farmacológico , Melioidose/tratamento farmacológico , Meropeném , Pessoa de Meia-Idade , Sri Lanka , Tienamicinas/uso terapêuticoRESUMO
We identified human bocavirus (HBoV) DNA by PCR in cerebrospinal fluid from adults and children with encephalitis in Sri Lanka. HBoV types 1, 2, and 3 were identified among these cases. Phylogenetic analysis of HBoV1 strain sequences found no subclustering with strains previously identified among encephalitis cases in Bangladesh.
Assuntos
Encefalite/diagnóstico , Bocavirus Humano/classificação , Bocavirus Humano/genética , Infecções por Parvoviridae/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Proteínas do Capsídeo/genética , Criança , DNA Viral/genética , Encefalite/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/epidemiologia , Filogenia , Sorotipagem , Sri Lanka/epidemiologia , Adulto JovemRESUMO
OBJECTIVE: To demonstrate the burden of Haemophilus influenzae type b (Hib) disease in Sri Lanka and provide information for decision-making in public health planning and vaccine introduction. METHODS: This was a prospective, population-based study carried out in 2004, to describe the epidemiology and calculate the incidence of meningitis caused by Hib in children <5 years of age in the district of Colombo, Sri Lanka. Hib was identified in cerebrospinal fluid (CSF) specimens by culture and antigen detection (latex agglutination test; LAT). RESULTS: The lumbar puncture rate in children <5 years of age was 1.9%. A causative bacterial organism was identified in 108 meningitis cases, and in 54 (50%) this was Hib. The LAT increased the Hib detection rate in CSF four-fold. In 2004, the annual incidence of Hib meningitis in Colombo was 20.1 cases per 100000 children aged <5 years. CONCLUSIONS: This study is the first from Sri Lanka reporting the Hib meningitis incidence rate pre-vaccine introduction. The reported incidence rate is one of the highest from the Asian region, but is likely an underestimation considering the difficulties in the laboratory identification of Hib.