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1.
BMC Med Res Methodol ; 22(1): 64, 2022 03 06.
Artigo em Inglês | MEDLINE | ID: mdl-35249528

RESUMO

BACKGROUND: With advances in cancer diagnosis and treatment, women with early-stage breast cancer (ESBC) are living longer, increasing the number of patients receiving post-treatment follow-up care. Best-practice survivorship models recommend transitioning ESBC patients from oncology-provider (OP) care to community-based care. While developing materials for a future randomized controlled trial (RCT) to test the feasibility of a nurse-led Telephone Survivorship Clinic (TSC) for a smooth transition of ESBC survivors to follow-up care, we explored patients' and OPs' reactions to several of our proposed methods. METHODS: We used a qualitative study design with thematic analysis and a two-pronged approach. We interviewed OPs, seeking feedback on ways to recruit their ESBC patients for the trial, and ESBC patients, seeking input on a questionnaire package assessing outcomes and processes in the trial. RESULTS: OPs identified facilitators and barriers and offered suggestions for study design and recruitment process improvement. Facilitators included the novelty and utility of the study and simplicity of methods; barriers included lack of coordination between treating and discharging clinicians, time constraints, language barriers, motivation, and using a paper-based referral letter. OPs suggested using a combination of electronic and paper referral letters and supporting clinicians to help with recruitment. Patient advisors reported satisfaction with the content and length of the assessment package. However, they questioned the relevance of some questions (childhood trauma) while adding questions about trust in physicians and proximity to primary-care providers. CONCLUSIONS: OPs and patient advisors rated our methods for the proposed trial highly for their simplicity and relevance then suggested changes. These findings document processes that could be effective for cancer-patient recruitment in survivorship clinical trials.


Assuntos
Neoplasias da Mama , Sobreviventes , Assistência ao Convalescente , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/terapia , Feminino , Humanos , Oncologia , Inquéritos e Questionários
2.
Cancer ; 124(5): 1053-1060, 2018 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-29355901

RESUMO

BACKGROUND: Head and neck cancers are associated with high rates of depression, which may increase the risk for poorer immediate and long-term outcomes. Here it was hypothesized that greater depressive symptoms would predict earlier mortality, and behavioral (treatment interruption) and biological (treatment response) mediators were examined. METHODS: Patients (n = 134) reported depressive symptomatology at treatment planning. Clinical data were reviewed at the 2-year follow-up. RESULTS: Greater depressive symptoms were associated with significantly shorter survival (hazard ratio, 0.868; 95% confidence interval [CI], 0.819-0.921; P < .001), higher rates of chemoradiation interruption (odds ratio, 0.865; 95% CI, 0.774-0.966; P = .010), and poorer treatment response (odds ratio, 0.879; 95% CI, 0.803-0.963; P = .005). The poorer treatment response partially explained the depression-survival relation. Other known prognostic indicators did not challenge these results. CONCLUSIONS: Depressive symptoms at the time of treatment planning predict overall 2-year mortality. Effects are partly influenced by the treatment response. Depression screening and intervention may be beneficial. Future studies should examine parallel biological pathways linking depression to cancer survival, including endocrine disruption and inflammation. Cancer 2018;124:1053-60. © 2018 American Cancer Society.


Assuntos
Depressão/fisiopatologia , Transtorno Depressivo/fisiopatologia , Neoplasias de Cabeça e Pescoço/fisiopatologia , Avaliação de Resultados em Cuidados de Saúde/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Quimiorradioterapia/métodos , Feminino , Neoplasias de Cabeça e Pescoço/psicologia , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde/estatística & dados numéricos , Prognóstico , Modelos de Riscos Proporcionais , Adulto Jovem
3.
Psychooncology ; 27(5): 1404-1411, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-28672093

RESUMO

OBJECTIVE: Adolescents and young adult cancer survivors (AYA) are a unique subpopulation with high levels of distress and unmet need. To date, studies have not disentangled distress due to developmental life stage from distress due to cancer survivorship. This population-based study allowed a direct comparison between AYA cancer survivors, older adult (OA) cancer survivors, and their cancer-free peers. METHODS: We combined 4 annual cycles of the Canadian Community Health Survey (CCHS, 2007-2010) to obtain a final sample of 239 316 respondents. We dichotomized the total sample into AYA (15-39 years, n = 83 770) and OA (40+, n = 155 546). Two standardized questions identified cancer survivors (n = 14 592). The self-reported outcomes of interest included self-perceived health and mental health, and health care professional diagnosed mood and anxiety disorders. We used weighted logistic regression models to examine for associations, including an interaction term to assess for effect modification by age. RESULTS: After adjusting for confounders, cancer survivorship in AYAs was strongly associated with higher prevalence of both mood (OR 2.00, 95% CI 1.44-2.77) and anxiety (OR 2.20, 95% CI 1.70-2.86) disorders as compared to their cancer-free peers. OA survivors had a weaker association in the same direction (OR 1.10, 95% CI 1.01-1.21 and OR 1.15, 95% CI 1.02-1.30, respectively). AYA cancer survivors reported higher levels of poor self-perceived mental health than their cancer-free peers (OR 1.49, 95% CI 1.03-2.14), while there was no significant difference from cancer-free peers for OAs (OR 1.03, 95% CI 0.92-1.15). CONCLUSIONS: AYA cancer survivors experience a significantly higher risk of psychosocial distress than both their cancer-free peers and OA survivors.


Assuntos
Ansiedade/psicologia , Sobreviventes de Câncer/psicologia , Neoplasias/psicologia , Grupo Associado , Qualidade de Vida , Estresse Psicológico/psicologia , Adolescente , Fatores Etários , Idoso , Canadá , Feminino , Humanos , Masculino , Saúde Mental , Neoplasias/mortalidade , Neoplasias/patologia , Prevalência , Inquéritos e Questionários , Resultado do Tratamento , Adulto Jovem
4.
Psychooncology ; 27(8): 1979-1986, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29740904

RESUMO

OBJECTIVE: The population of adult survivors of childhood cancers (ASCCs) is growing, resulting in unique long-term challenges. This study explored experiences of perceived unmet ASCC survivorship needs. METHODS: We invited ASCCs to complete surveys sent through the cancer registry. Four open-ended questions allowed participants to write in comments. We analyzed responses to these open-ended questions thematically, employing a process of constant comparison. RESULTS: Our sample included 94 ASCCs who completed open-ended questions (61 female; aged 20-78 years, mean age = 34.47, SD = 11.84, mean = 23.27 years post diagnosis). Identified themes included (1) overlooked experiences of distress; (2) lack of counseling: system, patient, and family barriers; (3) difficulty negotiating future life milestones exacerbated by lack of knowledge; and (4) dissatisfaction with service provision: past and present. Prevalent issues identified by participants included lack of supportive care to address needs, distress due to missed developmental milestones as a result of cancer, lack of knowledge about late-term and long-term effects of cancer treatment, and concern over absence of organized long-term follow-up. CONCLUSIONS: Adult survivors of childhood cancers continue to experience unmet needs during their cancer diagnosis, treatment, and long into survivorship due to the treatment for cancer and ongoing side effects. Solutions could focus on addressing the needs of survivors to bridge system gaps and barriers. Specifically, there is a need to improve psychological interventions and transitions from pediatric to adult-care facilities.


Assuntos
Sobreviventes de Câncer/psicologia , Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Avaliação das Necessidades/estatística & dados numéricos , Neoplasias/psicologia , Sobrevivência , Adulto , Idoso , Atenção à Saúde , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Qualidade de Vida , Adulto Jovem
5.
Proc Natl Acad Sci U S A ; 112(35): 10950-5, 2015 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-26269569

RESUMO

Age-related macular degeneration (AMD) is associated with dysfunction and death of retinal pigment epithelial (RPE) cells. Cell-based approaches using RPE-like cells derived from human pluripotent stem cells (hPSCs) are being developed for AMD treatment. However, most efficient RPE differentiation protocols rely on complex, stepwise treatments and addition of growth factors, whereas small-molecule-only approaches developed to date display reduced yields. To identify new compounds that promote RPE differentiation, we developed and performed a high-throughput quantitative PCR screen complemented by a novel orthogonal human induced pluripotent stem cell (hiPSC)-based RPE reporter assay. Chetomin, an inhibitor of hypoxia-inducible factors, was found to strongly increase RPE differentiation; combination with nicotinamide resulted in conversion of over one-half of the differentiating cells into RPE. Single passage of the whole culture yielded a highly pure hPSC-RPE cell population that displayed many of the morphological, molecular, and functional characteristics of native RPE.


Assuntos
Diferenciação Celular/efeitos dos fármacos , Células-Tronco Pluripotentes/efeitos dos fármacos , Epitélio Pigmentado da Retina/citologia , Ensaios de Triagem em Larga Escala , Humanos , Células-Tronco Pluripotentes/citologia , Reação em Cadeia da Polimerase
6.
Support Care Cancer ; 25(7): 2285-2296, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-28281051

RESUMO

OBJECTIVE: This initial study examined a therapist-led, synchronous, online support group (OSG) with psycho-education (OSG + E) compared to self-help psycho-education (E). The study aims were to examine proof of concept-feasibility, acceptability, and usefulness-and to hone methods for a formal RCT. METHODS: One hundred five young breast cancer survivors (<50 years) post-treatment were randomized either to OSG + E or E. OSG + E received a therapist-led 10-week synchronous online intervention. E received a self-help workbook. Assessments were at baseline, 10 weeks, and 3 months, with willing OSG + E members completing post-study interviews. Researchers used inductive analysis, generating qualitative themes for feasibility, acceptability, and usefulness. We examined trajectories for one primary and two secondary quantitative outcomes and a combined moderator to discover who preferentially benefitted from the intervention. RESULTS: Qualitative analyses revealed that synchronous chat was at times challenging, but minimal technical coaching, structure, set topics, and professional facilitation enabled conversations that were focused and meaningful. A combined moderator indicated that generally more women benefitted from OSG + E relative to E and particularly those women in semi-rural and rural areas. CONCLUSIONS: This study suggests that therapist-led synchronous OSGs are feasible, acceptable, and useful for young breast cancer survivors and that a future RCT with a larger sample size, perhaps more focused on non-urban areas, is needed to establish its effectiveness.


Assuntos
Neoplasias da Mama/psicologia , Internet/estatística & dados numéricos , Grupos de Autoajuda/estatística & dados numéricos , Sobreviventes/psicologia , Adulto , Comunicação , Feminino , Humanos , Pessoa de Meia-Idade
7.
Cancer ; 122(8): 1185-200, 2016 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-26828426

RESUMO

BACKGROUND: Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between-group outcomes across 24 weeks. METHODS: Sixty patients with head and neck cancer were randomized to engage in a 12-week lifestyle intervention and progressive resistance-training program either during radiation treatment or immediately after completion. The primary outcome of body composition--specifically, lean body mass, body mass index, and body fat--as well as secondary outcomes of fitness, quality of life, depression, and nutrition status were evaluated. RESULTS: The progressive resistance-training intervention carried out during treatment did not significantly influence the primary outcome of body composition, despite a significant increase in weekly physical activity reported by the intervention group. A small-to-medium intervention effect was noted for some secondary outcomes, including fitness, quality of life, and nutrition status. Regardless of whether patients received the immediate or delayed progressive resistance-training intervention, the analysis revealed a main effect of time on body composition, fitness, quality of life, depression, and nutritional scores. CONCLUSIONS: Although the intervention during treatment did not reduce the loss of lean body mass, delaying the exercise program until after treatment completion was associated with improved intervention adherence, a finding with important clinical implications.


Assuntos
Composição Corporal/fisiologia , Terapia por Exercício/métodos , Neoplasias de Cabeça e Pescoço/reabilitação , Estilo de Vida , Qualidade de Vida , Autorrelato , Adulto , Fatores Etários , Idoso , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Estado Nutricional , Avaliação de Resultados da Assistência ao Paciente , Aptidão Física/fisiologia , Prognóstico , Treinamento Resistido/métodos , Fatores Sexuais , Estatísticas não Paramétricas , Resultado do Tratamento
8.
Cancer ; 122(15): 2408-17, 2016 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-27198057

RESUMO

BACKGROUND: We conducted a randomized controlled trial of peer-counseling for newly diagnosed breast cancer (BC) patients as a community/research collaboration testing an intervention developed jointly by a community-based-organization serving women with cancer and university researchers. METHODS: We recruited 104 women newly diagnosed with BC at any disease stage. Prior to randomization, all received a one-time visit with an oncology nurse who offered information and resources. Afterwards, we randomized half to receive a match with a Navigator with whom they could have contact for up to 6 months. We recruited, trained, and supervised 30 peer counselors who became "Navigators." They were at least one-year post-diagnosis with BC. Controls received no further intervention. We tested the effect of intervention on breast-cancer-specific well-being and trauma symptoms as primary outcomes, and several secondary outcomes. In exploratory analyses, we tested whether responding to their diagnosis as a traumatic stressor moderated outcomes. RESULTS: We found that, compared with the control group, receiving a peer-counseling intervention significantly improved breast-cancer-specific well-being (p=0.01, Cohen's d=0.41) and maintained marital adjustment (p=0.01, Cohen's d=0.45) more effectively. Experiencing the diagnosis as a traumatic stressor moderated outcomes: those with a peer counselor in the traumatic stressor group improved significantly more than controls on well-being, trauma and depression symptoms, and cancer self-efficacy. CONCLUSIONS: Having a peer counselor trained and supervised to recognize and work with trauma symptoms can improve well-being and psychosocial morbidity during the first year following diagnosis of BC. Cancer 2016;122:2408-2417. © 2016 American Cancer Society.


Assuntos
Neoplasias da Mama/epidemiologia , Neoplasias da Mama/psicologia , Aconselhamento , Grupo Associado , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/terapia , Estudos de Casos e Controles , Terapia Combinada , Feminino , Humanos , Estadiamento de Neoplasias , Fatores de Risco
9.
Cancer ; 121(3): 476-84, 2015 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-25367403

RESUMO

BACKGROUND: Group psychosocial interventions including mindfulness-based cancer recovery (MBCR) and supportive-expressive group therapy (SET) can help breast cancer survivors decrease distress and influence cortisol levels. Although telomere length (TL) has been associated with breast cancer prognosis, the impact of these two interventions on TL has not been studied to date. METHODS: The objective of the current study was to compare the effects of MBCR and SET with a minimal intervention control condition (a 1-day stress management seminar) on TL in distressed breast cancer survivors in a randomized controlled trial. MBCR focused on training in mindfulness meditation and gentle Hatha yoga whereas SET focused on emotional expression and group support. The primary outcome measure was relative TL, the telomere/single-copy gene ratio, assessed before and after each intervention. Secondary outcomes were self-reported mood and stress symptoms. RESULTS: Eighty-eight distressed breast cancer survivors with a diagnosis of stage I to III cancer (using the American Joint Committee on Cancer (AJCC) TNM staging system) who had completed treatment at least 3 months prior participated. Using analyses of covariance on a per-protocol sample, there were no differences noted between the MBCR and SET groups with regard to the telomere/single-copy gene ratio, but a trend effect was observed between the combined intervention group and controls (F [1,84], 3.82; P = .054; η(2) = .043); TL in the intervention group was maintained whereas it was found to decrease for control participants. There were no associations noted between changes in TL and changes in mood or stress scores over time. CONCLUSIONS: Psychosocial interventions providing stress reduction and emotional support resulted in trends toward TL maintenance in distressed breast cancer survivors, compared with decreases in usual care.


Assuntos
Neoplasias da Mama/metabolismo , Neoplasias da Mama/terapia , Psicoterapia/métodos , Telômero/metabolismo , Neoplasias da Mama/psicologia , Feminino , Humanos , Hidrocortisona/metabolismo , Estudos Longitudinais , Meditação , Pessoa de Meia-Idade , Atenção Plena , Sobreviventes/psicologia , Yoga
10.
Psychosom Med ; 77(4): 346-55, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25886831

RESUMO

OBJECTIVE: High levels of high-frequency heart rate variability (HF-HRV), related to parasympathetic-nervous-system functioning, have been associated with longer survival in patients with myocardial infarction and acute trauma and in patients undergoing palliative care. From animal studies linking higher vagal activity with better immune system functioning and reduced metastases, we hypothesized that higher HF-HRV would predict longer survival in patients with metastatic or recurrent breast cancer (MRBC). METHODS: Eighty-seven patients with MRBC participated in a laboratory task including a 5-minute resting baseline electrocardiogram. HF-HRV was computed as the natural logarithm of the summed power spectral density of R-R intervals (0.15-0.50 Hz). In this secondary analysis of a study testing whether diurnal cortisol slope predicted survival, we tested the association between resting baseline HF-HRV on survival using Cox proportional hazards models. RESULTS: A total of 50 patients died during a median follow-up of 7.99 years. Higher baseline HF-HRV predicted significantly longer survival, with a hazard ratio of 0.75 (95% confidence interval = 0.60-0.92, p = .006). Visceral metastasis status and baseline heart rate were related to both HF-HRV and survival. However, a combination of HF-HRV and heart rate further improved survival prediction, with a hazard ratio of 0.64 (95% confidence interval = 0.48-0.85, p = .002). CONCLUSIONS: Vagal activity of patients with MRBC strongly predicted their survival, extending the known predictive window of HF-HRV in cancer beyond palliative care. Vagal activity can be altered by behavioral, pharmacological, and surgical interventions and may be a promising target for extending life expectancy in patients with metastasizing cancer.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Neoplasias da Mama/fisiopatologia , Frequência Cardíaca/fisiologia , Metástase Neoplásica/fisiopatologia , Recidiva Local de Neoplasia/fisiopatologia , Análise de Sobrevida , Nervo Vago/fisiopatologia , Adulto , Idoso , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade
11.
J Natl Compr Canc Netw ; 13(6): 762-71, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26085392

RESUMO

PURPOSE: Oncology centers in public health systems often transfer routine follow-up of patients with early-stage breast cancer (BC) to primary care physicians because of the increasing numbers of survivors and evidence supporting the safety of this practice. After transfer of care, it is unknown how BC survivors fare with treatment and surveillance goals, and whether they have unmet needs for access to specialist care. This study conducted in a sample of women in Alberta, Canada, examined adherence with follow-up guidelines, symptoms, and need for a telephone-based survivorship clinic. METHODS: Through the Alberta Cancer Registry, we randomly invited women with stage I-III invasive BC (N=960) to participate. Of those, 272 responded, and 240 consented to a structured telephone interview and chart review. RESULTS: Women adhered well to follow-up guidelines for mammogram, but less so for clinical examination and endocrine therapy (ET). However, most patients reported ongoing bothersome symptoms, which tended to be higher in those not on ET. More than one-third of patients reported ongoing needs (managing weight, side effects, exercise adherence, and psychosocial health). Younger, fatigued or depressed, nonurban women not on ET reported the most need for a telephone clinic. CONCLUSIONS: Adherence with follow-up goals (examination, mammography, ET) was better than expected. Despite this, interest in a telephone survivorship clinic was high. Perceived needs included symptom management plus support for lifestyle behavior change. Medical follow-up needs might be well-met by discharge to primary care. However, high levels of ongoing symptoms and psychosocial needs would suggest that telephone-based survivorship clinics, psychosocial and exercise interventions, or transition programs might benefit the survivorship experience of patients with BC.


Assuntos
Neoplasias da Mama/terapia , Neoplasias da Mama/patologia , Detecção Precoce de Câncer , Feminino , Seguimentos , Fidelidade a Diretrizes , Humanos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Alta do Paciente , Atenção Primária à Saúde , Resultado do Tratamento
12.
J Behav Med ; 38(1): 171-82, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25096409

RESUMO

Studies indicate that story-telling and emotional expression may be important therapeutic mechanisms. This study examined how they work together over 1 year of supportive-expressive group therapy (SET). Participants were 41 women randomized to SET. We coded emotional expression and story types (story vs. non-story) at the initial session, 4, 8, and 12 months. Women engaged in more storytelling in their initial than later sessions. In later sessions, women expressed significantly more emotion, specifically compassion and high-arousal positive affect. Direct communication (non-story) allowed more positive but also more defensive expression as women supported and challenged each other. Greater hostility in non-story and greater constrained anger during story were associated with increasing depression. Greater high-arousal positive affect in non-story and greater primary negative affect in story were associated with increasing social network size. These results inform clinicians about cues they might use to improve the effectiveness of cancer support groups.


Assuntos
Neoplasias da Mama/terapia , Comunicação , Emoções , Psicoterapia de Grupo , Grupos de Autoajuda , Feminino , Humanos , Pessoa de Meia-Idade , Narração , Apoio Social
13.
J Behav Med ; 37(1): 22-36, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23085787

RESUMO

Clinicians working with cancer patients listen to them, observe their behavior, and monitor their physiology. How do we proceed when these indicators do not align? Under self-relevant stress, non-cancer repressors respond with high arousal but report low anxiety; the high-anxious report high anxiety but often have lower arousal. This study extends discrepancy research on repressors and the high-anxious to a metastatic breast cancer sample and examines physician rating of coping. Before and during a Trier Social Stress Test (TSST), we assessed affect, autonomic reactivity, and observers coded emotional expression from TSST videotapes. We compared non-extreme (N = 40), low-anxious (N = 16), high-anxious (N = 19), and repressors (N = 19). Despite reported low anxiety, repressors expressed significantly greater Tension or anxiety cues. Despite reported high anxiety, the high-anxious expressed significantly greater Hostile Affect rather than Tension. Physicians rated both groups as coping significantly better than others. Future research might productively study physician-patient interaction in these groups.


Assuntos
Adaptação Psicológica , Afeto , Ansiedade/psicologia , Nível de Alerta , Neoplasias da Mama/psicologia , Adulto , Idoso , Ansiedade/complicações , Neoplasias da Mama/complicações , Feminino , Resposta Galvânica da Pele/fisiologia , Frequência Cardíaca/fisiologia , Humanos , Pessoa de Meia-Idade , Repressão Psicológica , Autorrelato
14.
Psychooncology ; 22(1): 168-76, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21971977

RESUMO

BACKGROUND: As the concept of distress as the 6th vital sign gains strength in cancer care, research on the experience of patients is critical. This study longitudinally examined patients' physical and psychosocial concerns over the year following diagnosis. METHODS: Between July 2007 and February 2008, patients attending a large tertiary cancer centre were recruited to participate in a study examining their levels of distress, pain, fatigue, depression and anxiety over a year. RESULTS: A total of 877 patients provided baseline data with 620, 589 and 505 retained at 3, 6 and 12 months, respectively. Overall, levels of distress, depression and anxiety decreased significantly over the study period. No significant changes were found in levels of pain or fatigue. Demographics (being unmarried) and medical interventions (particularly having radiation therapy) predicted persistent distress, anxiety and depression, whereas receiving psychosocial support predicted decreased levels of distress, anxiety and depression. Some patients reported continued clinical levels of distress (29%), pain (19%) and fatigue (40%) 12 months post diagnosis. DISCUSSION: For some people, distress, depression, and anxiety may be transient and decrease over time, but for others they may be sustained. Pain and fatigue may remain present in many cancer patients. There is a need to modify current clinical practice to facilitate the appropriate assessment and management of distress.


Assuntos
Ansiedade/epidemiologia , Depressão/epidemiologia , Fadiga/epidemiologia , Neoplasias/psicologia , Dor/epidemiologia , Estresse Psicológico/epidemiologia , Adaptação Psicológica , Adulto , Idoso , Ansiedade/diagnóstico , Ansiedade/psicologia , Canadá/epidemiologia , Depressão/diagnóstico , Depressão/psicologia , Fadiga/diagnóstico , Fadiga/psicologia , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Morbidade , Neoplasias/diagnóstico , Neoplasias/epidemiologia , Dor/diagnóstico , Dor/psicologia , Prevalência , Escalas de Graduação Psiquiátrica , Análise de Regressão , Fatores de Risco , Apoio Social , Fatores Socioeconômicos , Estresse Psicológico/diagnóstico , Estresse Psicológico/psicologia
15.
J Clin Psychol ; 69(3): 264-77, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23280695

RESUMO

OBJECTIVE: This study sought to identify relationships between trait mindfulness, repressive, and suppressive emotional styles, and the relative importance of these traits in their association with self-reported psychological health among women with breast cancer. METHOD: Of the 277 women with breast cancer accrued in the study, 227 (81.9%) completed a set of questionnaires assessing personality traits, stress symptoms, and mood. RESULTS: High levels of mindfulness were associated with fewer stress-related symptoms and less mood disturbance, while high levels of suppression were associated with poorer self-reported health. CONCLUSION: Individuals' dispositional ways to manage negative emotions were associated with the experience of symptoms and aversive moods. Helping patients cultivate mindful insights and reduce deliberate emotional inhibition may be a useful focus for psycho-oncological interventions.


Assuntos
Afeto/fisiologia , Conscientização/fisiologia , Neoplasias da Mama/psicologia , Personalidade/fisiologia , Repressão Psicológica , Estresse Psicológico/psicologia , Neoplasias da Mama/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Inventário de Personalidade , Autorrelato , Estresse Psicológico/etiologia , Inquéritos e Questionários
16.
J Emerg Nurs ; 39(4): 409-11, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23657006

RESUMO

Obtaining an actual weight is critical to accurate medication dosing. Knowledge of length/height is critical to equipment sizing. Rapid and accurate measurement of both upon arrival at the emergency department increases patient safety and staff comfort in the case of a decompensating child requiring resuscitation. Having a process in place that works with the layout, medical record, and budget of the department increases safety for the patient and may improve outcomes, and if the process is led by staff champions, acceptance of the process may be faster. Regardless of the actual method, patient safety and staff satisfaction can be improved with a simple process that prepares for an emergency in pediatric care.


Assuntos
Estatura/fisiologia , Peso Corporal/fisiologia , Pesos e Medidas Corporais/métodos , Enfermagem em Emergência/métodos , Pediatria/métodos , Triagem/métodos , Pesos e Medidas Corporais/instrumentação , Pré-Escolar , Serviço Hospitalar de Emergência , Humanos
17.
BMC Cancer ; 12: 446, 2012 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-23031071

RESUMO

BACKGROUND: Research on physical activity and nutrition interventions aimed at positively impacting symptom management, treatment-related recovery and quality of life has largely excluded head and neck (HN) cancer populations. This translates into a lack of clinical programming available for these patient populations. HN cancer patients deal with severe weight loss, with more than 70% attributed to lean muscle wasting, leading to extended recovery times, decreased quality of life (QoL), and impaired physical functioning. To date, interventions to address body composition issues have focused solely on diet, despite findings that nutritional therapy alone is insufficient to mitigate changes. A combined physical activity and nutrition intervention, that also incorporates important educational components known to positively impact behaviour change, is warranted for this population. Our pilot work suggests that there is large patient demand and clinic support from the health care professionals for a comprehensive program. METHODS/DESIGN: Therefore, the purpose of the present study is to examine the impact and timing of a 12-week PA and nutrition intervention (either during or following treatment) for HN cancer patients on body composition, recovery, serum inflammatory markers and quality of life. In addition, we will examine the impact of a 12-week maintenance program, delivered immediately following the intervention, on adherence, patient-reported outcomes (i.e., management of both physical and psychosocial treatment-related symptoms and side-effects), as well as return to work. DISCUSSION: This research will facilitate advancements in patient wellness, survivorship, and autonomy, and carve the path for a physical-activity and wellness-education model that can be implemented in other cancer centers. TRIAL REGISTRATION: Current Controlled Trials NCT01681654.


Assuntos
Dietoterapia/métodos , Terapia por Exercício/métodos , Neoplasias de Cabeça e Pescoço/reabilitação , Nível de Saúde , Atividades Cotidianas , Adulto , Biomarcadores/sangue , Composição Corporal/fisiologia , Caquexia/sangue , Citocinas/sangue , Feminino , Comportamentos Relacionados com a Saúde , Humanos , Masculino , Educação de Pacientes como Assunto , Assistência Centrada no Paciente , Qualidade de Vida , Sobreviventes , Síndrome de Emaciação/sangue
18.
BMC Cancer ; 12: 441, 2012 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-23031647

RESUMO

BACKGROUND: Very few studies examine the longitudinal prevalence of problems and the awareness or use of clinical programs by patients who report these problems. Of the studies that examine age, gender and marital status as predictors of a range of patient outcomes, none examines the interactions between these demographic variables. This study examined the typical trajectory of common practical and psychosocial problems endorsed over 12 months in a usual-care sample of cancer outpatients. Specifically, we examined whether marital status, sex, age, and their interactions predicted these trajectories. We did not actively triage or refer patients in this study in order to examine the natural course of problem reports. METHODS: Patients completed baseline screening (N = 1196 of 1707 approached) and the sample included more men (N = 696) than women (N = 498), average age 61.1 years. The most common diagnoses were gastrointestinal (27.1%), prostate (19.2%), skin (11.1%) and gynecological (9.2%). Among other measures, patients completed a Common Problem Checklist and Psychosocial Resources Use questions at baseline, 3, 6, and 12 months using paper and pencil surveys. RESULTS: Results indicated that patients reported psychosocial problems more often than practical and both decreased significantly over time. Younger single patients reported more practical problems than those in committed relationships. Younger patients and women of all ages reported more psychosocial problems. Among a number of interesting interactions, for practical problems, single older patients improved more; whereas among married people, younger patients improved more. For psychosocial problems we found that older female patients improved more than younger females, but among males, it was younger patients who improved more. Young single men and women reported the most past-and future-use of services. CONCLUSIONS: Younger women are particularly vulnerable to experiencing practical and psychosocial problems when diagnosed with cancer, but being married protects these younger women. Marriage appeared to buffer reports of both practical and psychosocial problems, and led to less awareness and use of services. Unexpectedly, young men reported the highest use of psychosocial services. This study informs clinical program development with information on these risk groups.


Assuntos
Neoplasias/psicologia , Estresse Psicológico/etiologia , Estresse Psicológico/psicologia , Fatores Etários , Feminino , Humanos , Masculino , Estado Civil , Programas de Rastreamento/métodos , Pessoa de Meia-Idade , Pacientes Ambulatoriais , Prevalência , Fatores Sexuais , Estresse Psicológico/diagnóstico
19.
Breast J ; 16(5): 481-9, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20642458

RESUMO

We conducted a nonrandomized study matching 42 women newly diagnosed with breast cancer (sojourners) with 39 trained breast cancer survivors (navigators) who provided one-on-one peer counseling for 3-6 months. Because little is known about how marital status might impact participants in such an intervention, we tested whether being married/partnered buffered navigators and sojourners from distress at baseline and over time. We examined baseline and slopes over time for change in depression and trauma symptoms, and emotional well-being. We were particularly concerned that being matched with a newly diagnosed breast cancer patient might trigger a re-experiencing of trauma symptoms for the navigator, so we examined a re-experiencing subscale. All participants completed baseline, 3-, 6-, and 12-month assessments. Our hypotheses were tested in separate Analyses of Variance (married versus not) for the 39 sojourners and 34 navigators who provided baseline assessments, and the 29 sojourners and 24 navigators who were matched and provided at least one follow-up. We found no significant baseline associations for navigators or sojourners. Being single/not married was associated with increasing depression symptoms over time in both navigators and sojourners compared with being married/partnered. By 12 months, these increases crossed above the clinical cut-off for significant depression symptoms. Single status did not predict increasing trauma symptoms over time. However, being single/not married predicted a significant increase in navigators' re-experiencing of trauma symptoms. Over time, married sojourners increased significantly in emotional well-being, whereas single/not married navigators did not differ from married navigators. In addition to providing ongoing training and emotional support to navigators, our findings indicate the importance of providing additional support for women who are not married or partnered.


Assuntos
Neoplasias da Mama/psicologia , Aconselhamento , Estado Civil , Qualidade de Vida/psicologia , Estresse Fisiológico , Neoplasias da Mama/diagnóstico , Feminino , Previsões , Humanos , Pessoa de Meia-Idade , Grupo Associado
20.
J Adolesc Young Adult Oncol ; 9(6): 676-682, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32614264

RESUMO

Few, scalable, evidence-based psychosocial interventions exist for adolescent and young adult cancer survivors (AYAs, 18-39 years old). Using an existing, facilitated, online synchronous chat group-plus-education model (OSG+E), we replaced their educational workbook with an AYA-created film to stimulate an age-specific, emotion-focused group discussion (OSG+V). This randomized proof-of-concept trial compared the two models' content suitability, group processes, and feasibility over 9 months in 34 male and female AYAs with a range of cancers. AYAs rated the OSG + V model more suitable, cohesive, and as having higher levels of important group processes than the OSG+E. A larger randomized trial is feasible for this AYA-appropriate, emotion-focused OSG + V model.


Assuntos
Neoplasias/psicologia , Psicoterapia/métodos , Mídias Sociais/normas , Adolescente , Adulto , Feminino , Humanos , Masculino , Estudo de Prova de Conceito , Adulto Jovem
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