Intestinal levodopa infusion: the Belgian experience.

Data concerning efficacy, safety, and patient satisfaction of levodopa/carbidopa intestinal gel (LCIG, Duodopa, AbbVie, Wavre, Belgium) infusion in routine clinical practice were needed to maintain reimbursement of the drug in Belgium. Patients with advanced Parkinson's disease in 27 neurology centers across Belgium were included. Of 100 patients who underwent naso-intestinal (NI) evaluation with LCIG, 67 received permanent treatment with LCIG via percutaneous endoscopic gastrostomy and jejunal tube (PEG/J). Efficacy was evaluated at baseline (on levodopa) and during a follow-up (FU) visit (on LCIG) using the Unified Parkinson's Disease Rating Scale (UPDRS) IV. Patient appraisal of the Duodopa system was evaluated using a visual analog scale for therapy compliance, user-friendliness, and global appreciation. Safety was assessed by reporting suspected adverse drug reactions (ADRs) and medical device-related complaints. FU evaluations were conducted in 37 patients. Significant improvement at FU was observed for motor complications (UPDRS IV) as the mean change from baseline to FU was -6.3 (95 % CI -8.1 to -4.5). Patient appraisal showed high scores for hospital delivery, user-friendliness, and patient global appreciation, as well as family appreciation of the system on daily life. Few ADRs and system malfunctions were reported, with no unexpected ADRs. In conclusion, the symptoms and impact of Parkinsonism improved markedly when LCIG PEG/J was initiated.

Neck movement speed in cervical dystonia.

Clinical scales of patients with cervical dystonia do not rate neck movement velocity. We prospectively measured range of neck movements and movement velocities in 35 consecutive patients with cervical dystonia (CD) and 29 normal controls. Reduction of peak velocities in patients with CD was the most robust abnormality and was correlated to TWSTRS. Coupled movements out of attempted movement plane were increased in the patient group. Movement range was moderately though significantly reduced. We conclude that slowing of voluntary neck movements is a frequent and hitherto unrecognized feature in CD.

Clinical and goniometric evaluation of patients with spasmodic torticollis.

BACKGROUND: Patients with cervical dystonia have been evaluated prospectively by the Toronto Western Spasmodic Torticollis Rating Scale and by cervical electrogoniometry. METHODS: Nineteen patients with cervical dystonia were studied. The Toronto Scale interobserver reliability was evaluated by two observers. An electrogoniometer was used to quantify cervical range of motion and velocity. The correlation between goniometric measurements and clinical evaluation was calculated. FINDINGS: The interobserver reliability was excellent for the total score (r(s) = 99) and good for the disability and the pain score (r > 0.88). However, global severity scale was shown to have a moderate reliability (r = 0.63) with r ranging from 0.37 to 0.98 for the individual items. The average loss of range of motion for flexion and extension, lateral bending and rotation was 18%, 12% and 21% respectively. For the velocity of movement, the average loss was proportionately greater than for the range of motion. (41%, 43% and 52% respectively). Correlation between the severity scale and range of motion was moderate but significant (r(s) = -0.52 to -0.67). Correlation between the Toronto severity score and the sum of movement velocities was significant for flexion-extension and lateral bending velocity sums (r(s) = -0.51; r(s) = -0.61). The lateral bending and rotation velocities were significantly correlated with pain and total scores (r(s) = -0.51). No significant correlation was observed for the disability score. INTERPRETATION: Three-dimensional electrogoniometry is helpful to quantify the velocity of neck movements and range of motion in patients with cervical dystonia.