Detalhe da pesquisa
1.
Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.
Mol Psychiatry
; 28(4): 1527-1544, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717740
2.
Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders.
Am J Hum Genet
; 106(3): 338-355, 2020 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32109419
3.
Extending the phenotypes associated with TRIO gene variants in a cohort of 25 patients and review of the literature.
Am J Med Genet A
; 191(7): 1722-1740, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36987741
4.
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.
Mol Cell
; 49(1): 94-108, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177739
5.
Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly.
J Med Genet
; 53(11): 735-742, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27418539
6.
The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons.
J Cell Sci
; 125(Pt 22): 5417-27, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22956537
7.
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.
Development
; 138(23): 5177-88, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22031541
8.
Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio.
J Cell Sci
; 123(Pt 12): 2111-23, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20519585
9.
M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.
Mol Biol Cell
; 18(5): 1734-43, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332503
10.
The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility.
J Cell Biol
; 219(9)2020 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32497170
11.
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse.
Neuron
; 46(2): 191-204, 2005 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15848799
12.
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.
J Cell Biol
; 165(6): 767-73, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15210726
13.
Trio controls the mature organization of neuronal clusters in the hindbrain.
J Neurosci
; 27(39): 10323-32, 2007 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17898204
14.
Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.
Sci Rep
; 8(1): 1410, 2018 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29362425
15.
The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth.
Curr Biol
; 12(4): 307-12, 2002 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-11864571
16.
Recurrent TRIO Fusion in Nontranslocation-Related Sarcomas.
Clin Cancer Res
; 23(3): 857-867, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27528700
17.
Comprehensive prognostic analysis in breast cancer integrating clinical, tumoral, micro-environmental and immunohistochemical criteria.
Springerplus
; 4: 528, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26405647
18.
The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
Mol Biol Cell
; 26(11): 2112-27, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851601
19.
Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.
J Cell Biol
; 210(5): 817-32, 2015 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-26323693
20.
Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio.
FEBS Lett
; 523(1-3): 35-42, 2002 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12123800