Detalhe da pesquisa
1.
Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill.
Int J Mol Sci
; 24(8)2023 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108440
2.
A first-in-man safety and pharmacokinetics study of nangibotide, a new modulator of innate immune response through TREM-1 receptor inhibition.
Br J Clin Pharmacol
; 84(10): 2270-2279, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29885068
3.
TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction.
Circ Res
; 116(11): 1772-82, 2015 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25840803
4.
Attenuation of responses to endotoxin by the triggering receptor expressed on myeloid cells-1 inhibitor LR12 in nonhuman primate.
Anesthesiology
; 120(4): 935-42, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24270127
5.
Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis.
J Immunol
; 188(11): 5585-92, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22551551
6.
THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1.
Cell Rep
; 43(2): 113773, 2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38350444
7.
Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients.
Crit Care Explor
; 5(3): e0869, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36861044
8.
Soluble TREM-1 plasma concentration predicts poor outcome in COVID-19 patients.
Intensive Care Med Exp
; 11(1): 51, 2023 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37574520
9.
Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial.
Lancet Respir Med
; 11(10): 894-904, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37269870
10.
Evaluation of the efficacy and safety of TREM-1 inhibition with nangibotide in patients with COVID-19 receiving respiratory support: the ESSENTIAL randomised, double-blind trial.
EClinicalMedicine
; 60: 102013, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37350989
11.
Triggering Receptors Expressed on Myeloid Cells 1 : Our New Partner in Human Oncology?
Front Oncol
; 12: 927440, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35875168
12.
Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity.
Front Endocrinol (Lausanne)
; 13: 983827, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36699032
13.
Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients.
EBioMedicine
; 77: 103893, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35219085
14.
Urine sTREM-1 assessment in diagnosing sepsis and sepsis-related acute kidney injury.
Crit Care
; 15(6): 1013, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22136371
15.
Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis.
Cell Mol Immunol
; 18(2): 452-460, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33420354
16.
Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial.
BMJ Open
; 11(7): e042921, 2021 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233965
17.
Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study.
Int J Cardiol
; 344: 213-219, 2021 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34534607
18.
Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19.
Biosci Rep
; 41(7)2021 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34195785
19.
Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study.
Front Med (Lausanne)
; 8: 780750, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35111777
20.
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.
J Clin Invest
; 131(2)2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33258804