Detalhe da pesquisa
1.
Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.
J Biol Chem
; 288(2): 1409-19, 2013 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23184956
2.
Chemical generation of bispecific antibodies.
Proc Natl Acad Sci U S A
; 107(52): 22611-6, 2010 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21149738
3.
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep
; 6: 26071, 2016 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27184415
4.
Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions.
Angew Chem Int Ed Engl
; 42(35): 4138-76, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14502729
5.
Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells.
Bioorg Med Chem Lett
; 16(19): 5194-8, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870428
6.
A facile route to paclitaxel C-10 carbamates.
Bioorg Med Chem Lett
; 15(10): 2477-80, 2005 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15863300
7.
Erythropoietin mimetics derived from solution phase combinatorial libraries.
J Am Chem Soc
; 124(4): 544-55, 2002 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-11804483
8.
Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
Biochemistry
; 41(48): 14206-15, 2002 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12450384
9.
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.
Proc Natl Acad Sci U S A
; 99(6): 3830-5, 2002 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-11891322
10.
Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Bioorg Med Chem
; 11(20): 4487-501, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129585
11.
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
Bioorg Med Chem
; 11(20): 4503-9, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129586
12.
Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorg Med Chem
; 11(20): 4511-21, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129587
13.
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
Biochemistry
; 42(20): 6043-56, 2003 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12755606
14.
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Bioorg Med Chem
; 10(8): 2739-49, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12057663