Detalhe da pesquisa
1.
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature
; 550(7677): 534-538, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045385
2.
Incorporating NOE-Derived Distances in Conformer Generation of Cyclic Peptides with Distance Geometry.
J Chem Inf Model
; 62(3): 472-485, 2022 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35029985
3.
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.
J Biol Chem
; 291(31): 16292-306, 2016 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226599
4.
Mitigation of reactive metabolite formation for a series of 3-amino-2-pyridone inhibitors of Bruton's tyrosine kinase (BTK).
Bioorg Med Chem Lett
; 27(3): 632-635, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28025004
5.
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
J Biol Chem
; 289(2): 942-55, 2014 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24225950
6.
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc Natl Acad Sci U S A
; 109(29): 11788-93, 2012 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22745160
7.
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).
Proc Natl Acad Sci U S A
; 108(26): 10484-9, 2011 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21670263
8.
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Nat Cancer
; 4(6): 812-828, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37277530
9.
A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication.
J Virol
; 85(11): 5287-300, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21450828
10.
Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease.
Proc Natl Acad Sci U S A
; 106(18): 7408-13, 2009 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376969
11.
GATA-1 associates with and inhibits p53.
Blood
; 114(1): 165-73, 2009 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19411634
12.
p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH.
Proc Natl Acad Sci U S A
; 105(1): 106-11, 2008 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160537
13.
NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase.
Biochemistry
; 48(9): 1964-74, 2009 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19215094
14.
NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16: structural similarities between VP16 and p53.
J Am Chem Soc
; 130(32): 10596-604, 2008 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18630911
15.
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Nat Struct Mol Biol
; 24(10): 848-856, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28825733
16.
Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.
J Med Chem
; 60(24): 10056-10070, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29166018
17.
Unveiling the Structural and Dynamic Nature of the Ubiquitin Code.
Structure
; 24(4): 498-499, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050685
18.
(1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7).
Biomol NMR Assign
; 10(2): 345-9, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27386854
19.
Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.
Structure
; 24(8): 1335-1345, 2016 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27452404
20.
Design of libraries targeting protein-protein interfaces.
ChemMedChem
; 8(5): 726-32, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23436619