Detalhe da pesquisa
1.
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Mol Cell
; 82(9): 1643-1659.e10, 2022 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35334231
2.
SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility.
PLoS Genet
; 19(1): e1010581, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36626385
3.
Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity.
PLoS Genet
; 18(6): e1010246, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35737728
4.
The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.
J Biol Chem
; 299(11): 105290, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37758001
5.
Multiple domain interfaces mediate SARM1 autoinhibition.
Proc Natl Acad Sci U S A
; 118(4)2021 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33468661
6.
FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.
J Biol Chem
; 298(3): 101647, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35101451
7.
The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.
Brain
; 145(11): 3787-3802, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35022694
8.
Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival.
Neurobiol Dis
; 163: 105586, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34923110
9.
A phytobacterial TIR domain effector manipulates NAD+ to promote virulence.
New Phytol
; 233(2): 890-904, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657283
10.
The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.
EMBO Rep
; 20(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30692130
11.
Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.
Proc Natl Acad Sci U S A
; 115(37): E8746-E8754, 2018 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30150401
12.
HSP90 is a chaperone for DLK and is required for axon injury signaling.
Proc Natl Acad Sci U S A
; 115(42): E9899-E9908, 2018 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30275300
13.
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.
Neurobiol Dis
; 127: 178-192, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30735704
14.
SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
Proc Natl Acad Sci U S A
; 113(41): E6271-E6280, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671644
15.
TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.
J Neurosci
; 36(17): 4681-9, 2016 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27122027
16.
Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.
Brain
; 139(Pt 12): 3092-3108, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27797810
17.
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Proc Natl Acad Sci U S A
; 110(10): 4045-50, 2013 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431148
18.
Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.
J Neurosci
; 34(28): 9338-50, 2014 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25009267
19.
SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury.
J Neurosci
; 34(25): 8398-410, 2014 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948796
20.
Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.
Neurobiol Dis
; 77: 13-25, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25726747