Detalhe da pesquisa
1.
RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation.
Int J Mol Sci
; 25(5)2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38474284
2.
Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma.
Int J Cancer
; 152(7): 1399-1413, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36346110
3.
Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD).
Int J Mol Sci
; 24(6)2023 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982372
4.
Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance.
Magn Reson Chem
; 60(5): 504-514, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35075680
5.
Alterations in the mitochondrial responses to PENAO as a mechanism of resistance in ovarian cancer cells.
Gynecol Oncol
; 138(2): 363-71, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26080289
6.
Employing pancreatic tumor γ-glutamyltransferase for therapeutic delivery.
Mol Pharm
; 11(5): 1500-11, 2014 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24654974
7.
BIO101 stimulates myoblast differentiation and improves muscle function in adult and old mice.
J Cachexia Sarcopenia Muscle
; 15(1): 55-66, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064183
8.
Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial.
EClinicalMedicine
; 68: 102383, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38545090
9.
A Phase 1 study for safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults.
J Cachexia Sarcopenia Muscle
; 14(3): 1259-1273, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37057316
10.
The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase.
Cancer Cell Int
; 12(1): 11, 2012 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22448968
11.
Noninvasive imaging of cell death using an Hsp90 ligand.
J Am Chem Soc
; 133(9): 2832-5, 2011 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21322555
12.
Mitochondrial metabolism inhibitors for cancer therapy.
Pharm Res
; 28(11): 2731-44, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21918915
13.
Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients.
Drug Discov Today
; 26(5): 1311-1318, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609783
14.
A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality.
Emerg Microbes Infect
; 10(1): 2256-2263, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34783636
15.
20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor.
J Mol Endocrinol
; 68(2): 77-87, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34825653
16.
A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -ß/δ, -γ, and RXR antagonists and by norbixin.
Aging (Albany NY)
; 13(18): 22040-22058, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34544906
17.
Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors.
Oxid Med Cell Longev
; 2020: 4984927, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33520083
18.
The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas.
Oncotarget
; 11(1): 46-61, 2020 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32002123
19.
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
Aging (Albany NY)
; 12(7): 6151-6171, 2020 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255762
20.
Insight into the selectivity of arsenic trioxide for acute promyelocytic leukemia cells by characterizing Saccharomyces cerevisiae deletion strains that are sensitive or resistant to the metalloid.
Int J Biochem Cell Biol
; 40(5): 1016-29, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160327