Detalhe da pesquisa
1.
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Cell
; 169(1): 148-160.e15, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28340340
2.
Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
PLoS Genet
; 18(4): e1010093, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35381001
3.
Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.
N Engl J Med
; 390(16): 1537-1538, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38657259
4.
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
Nature
; 510(7506): 547-51, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24870244
5.
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Mol Cell
; 48(6): 900-13, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142079
6.
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
Mol Cell
; 44(6): 851-63, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22195961
7.
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
J Biol Chem
; 291(20): 10635-45, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27022023
8.
Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.
J Biol Chem
; 288(10): 7117-26, 2013 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23329830
9.
Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5.
Biochim Biophys Acta
; 1804(8): 1676-83, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20005308
10.
Thiol dioxygenases: unique families of cupin proteins.
Amino Acids
; 41(1): 91-102, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20195658
11.
Nuclear FoxO1 inflames insulin resistance.
EMBO J
; 29(24): 4068-9, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21157481
12.
A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase.
Biochemistry
; 47(44): 11390-2, 2008 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18847220
13.
HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.
Physiol Genomics
; 33(2): 218-29, 2008 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18285520
14.
Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat.
Biochem J
; 394(Pt 1): 267-73, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16262602
15.
New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant.
Nutr Rev
; 62(9): 348-53, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15497768
16.
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.
Mol Metab
; 3(4): 419-31, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944901
17.
Mitochondrial biogenesis through activation of nuclear signaling proteins.
Cold Spring Harb Perspect Biol
; 5(7)2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818499
18.
In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity.
Methods Mol Biol
; 1077: 217-37, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24014410
19.
The sirtuin family's role in aging and age-associated pathologies.
J Clin Invest
; 123(3): 973-9, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23454760
20.
Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation.
Cancer Cell
; 21(2): 143-5, 2012 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22340586