Detalhe da pesquisa
1.
Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer.
Int J Cancer
; 147(2): 413-422, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31714586
2.
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.
N Engl J Med
; 375(26): 2550-2560, 2016 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28029918
3.
A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.
Invest New Drugs
; 34(2): 168-75, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26666244
4.
Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.
JAMA
; 311(23): 2397-405, 2014 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24938562
5.
University of Chicago phase II consortium trial of selumetinib (MEKi) demonstrates low tolerability and efficacy in relapsed DLBCL.
Br J Haematol
; 181(2): 264-267, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28419407
6.
A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors.
Invest New Drugs
; 30(2): 629-38, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20938713
7.
Low-dose radiotherapy as a chemopotentiator of gemcitabine in tumors of the pancreas or small bowel: a phase I study exploring a new treatment paradigm.
Int J Radiat Oncol Biol Phys
; 68(1): 172-7, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276612
8.
An efficient and scalable synthesis of substituted phenanthrenequinones by intramolecular Friedel-Crafts reaction of imidazolides.
Org Lett
; 9(21): 4103-6, 2007 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880225
9.
LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.
J Pharm Biomed Anal
; 146: 244-250, 2017 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28888173
10.
Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma.
J Cancer Res Clin Oncol
; 143(3): 439-445, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27921276
11.
A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer.
Clin Cancer Res
; 22(11): 2650-8, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26783290
12.
A Phase II Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple Myeloma.
Clin Cancer Res
; 22(5): 1067-75, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26446942
13.
Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer.
Sci Rep
; 5: 12122, 2015 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26161813
14.
Molecular profiling and targeted therapy for advanced thoracic malignancies: a biomarker-derived, multiarm, multihistology phase II basket trial.
J Clin Oncol
; 33(9): 1000-7, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25667274
15.
Searching for discrimination rules in protease proteolytic cleavage activity using genetic programming with a min-max scoring function.
Biosystems
; 72(1-2): 159-76, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14642665
16.
A phase I trial of vorinostat and alvocidib in patients with relapsed, refractory, or poor prognosis acute leukemia, or refractory anemia with excess blasts-2.
Clin Cancer Res
; 19(7): 1873-83, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23515411
17.
Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms.
Clin Cancer Res
; 17(10): 3388-97, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21447728
18.
Promoter methylation and response to chemotherapy and radiation in esophageal cancer.
Clin Gastroenterol Hepatol
; 4(6): 701-8, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16678495
19.
Characterizing proteolytic cleavage site activity using bio-basis function neural networks.
Bioinformatics
; 19(14): 1741-7, 2003 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-14512344
20.
Pulmonary resection after curative intent radiotherapy (>59 Gy) and concurrent chemotherapy in non-small-cell lung cancer.
Ann Thorac Surg
; 78(4): 1200-5; discussion 1206, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15464470