Advanced Functionalized Materials Based on Layer-by-Layer Assembled Natural Cellulose Nanofiber for Electrodes: A Review.

The depletion of fossil fuel resources and its impact on the environment provide a compelling motivation for the development of sustainable energy sources to meet the increasing demand for energy. Accordingly, research and development of energy storage devices have emerged as a critical area of focus. The electrode materials are critical in the electrochemical performance of energy storage devices, such as energy storage capacity and cycle life. Cellulose nanofiber (CNF) represents an important substrate with potentials in the applications of green electrode materials due to their environmental sustainability and excellent compatibility. By utilizing the layer-by layer (LbL) process, well-defined nanoscale multilayer structure is prepared on a variety of substrates. In recent years, increasing attention has focused on electrode materials produced from LbL process on CNFs to yield electrodes with exceptional properties, such as high specific surface area, outstanding electrical conductivity, superior electrochemical activity, and exceptional mechanical stability. This review provides a comprehensive overview on the development of functional CNF via the LbL approach as electrode materials.

Encapsulation of glucose oxidase in Fe(III)/tannic acid nanocomposites for effective tumor ablation via Fenton reaction.

Increasing the content of reactive oxygen species (ROS) with the assistance of nanoformulations in cancer cells via the Fenton reaction is considered an effective method to treat cancer. However, the efficiency of the Fenton reaction is affected by the level of H2O2, the selection of iron ions in different nanoformulations, etc. Herein, we use FeIII-tannic acid (FeIIITA) nanocomposites as the carrier to deliver glucose oxidase (GOD) which can solve the problem of insufficient endogenous H2O2 by catalytically converting the glucose. In comparison with traditional Fe2+/Fe3+, FeIIITA nanocomposites perform higher catalytic activity in converting H2O2 to high toxic hydroxyl radicals (·OH) due to the TA-mediated reduction of Fe3+. So, the integration of GOD and TA in the construction of nanocomposites significantly enhances the efficiency of the Fenton reaction. In vitro experiments show that ·OH produced by GOD-FeIIITA nanocomposites can not only achieve a good anticancer effect at a low concentration but also promote degradability of the nanocomposites. When it is only 1.08 µg · ml-1, the cell apoptosis rate has reached 76.91%. In vivo experiments further demonstrate that GOD-FeIIITA nanocomposites can significantly inhibit tumor growth. So this work lays a good foundation for Fenton reaction-based cancer treatment.

Aptamer selection and applications for breast cancer diagnostics and therapy.

Aptamers are short non-coding, single-stranded oligonucleotides (RNA or DNA) developed through Systematic Evolution of Ligands by Exponential enrichment (SELEX) in vitro. Similar to antibodies, aptamers can bind to specific targets with high affinity, and are considered promising therapeutic agents as they have several advantages over antibodies, including high specificity, stability, and non-immunogenicity. Furthermore, aptamers can be produced at a low cost and easily modified, and are, therefore, called "chemical antibodies". In the past years, a variety of aptamers specifically bound to both breast cancer biomarkers and cells had been selected. Besides, taking advantage of nanomaterials, there were a number of aptamer-nanomaterial conjugates been developed and widely investigated for diagnostics and targeted therapy of breast cancer. In this short review, we first present a systematical review of various aptamer selection methods. Then, various aptamer-based diagnostic and therapeutic strategies of breast cancer were provided. Finally, the current problems, challenges, and future perspectives in the field were thoroughly discussed.

Polydopamine-Anchored Cellulose Nanofiber Flexible Aerogel with High Charge Transfer as a Substrate for Conductive Materials.

In order to obtain a flexible aerogel substrate for conductive materials used in the electrode, polydopamine-anchored cellulose nanofiber (PDA@CNF) was introduced into a polyethylene imine-poly(vinyl alcohol) (PEI-PVA) cross-linking network which used 4-formylphenylboronic acid (4FPBA) as bridge. The incorporation of rigid CNF as a structural scaffold effectively improved the pore architecture of the aerogel, potentially providing substantial advantages for the infiltration and deposition of conductive materials. Additionally, the outstanding stability and flexibility exhibited by the aerogel in aqueous solutions suggest its significant potential for applications in flexible electrodes. Furthermore, electrochemical experiments showed that the rapid pathway formed between PDA and PEI could enhance the charge-transfer rate within the aerogel substrate. It is anticipated that such an enhancement would significantly benefit the electrochemical attributes of the electrode. Inspired by mussels, our introduced PDA-anchored rigid CNF into flexible polymer networks to fabricate aerogel substrates for electrode materials. This study would contribute to the development and utilization of flexible electrodes while reducing carbon footprint in energy production and conversion processes.

Hierarchical electrodes with superior cycling performance using porous material based on cellulose nanofiber as flexible substrate.

The development and application of flexible electrodes with extended cycle life have long been a focal point in the field of energy research. In this study, positively charged polyethylene imine (PEI) and conductive polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) with negative charge were alternately deposited onto a cellulose nanofiber (CNF) porous material utilizing pressure gradient-assisted layer-by-layer (LbL) self-assembly technology. The flexible substrate, characterized by a three-dimensional porous structure reinforced with stiff CNF, not only facilitated high charge storage but also enhanced the electrode's cycling life by reducing the volume changes of PEDOT:PSS. Furthermore, the exceptional wettability of PEI by the electrolyte could promote efficient charge transport within the electrode. The electrode with 10 PEI/PEDOT:PSS bilayer exhibits a capacitance of 63.71 F g-1 at the scan rate of 5 mV s-1 and a remarkable capacitance retention of 128 % after 3000 charge-discharge cycles. The investigation into the nanoscale layers of the LbL multilayer structure indicated that the exceptional cyclic performance was primarily attributed to the spatial constraints imposed by the rigid porous substrate layered structure on the deformation of PEDOT:PSS. This work is expected to make a significant contribution to the development of electrodes with high charge storage capacity and ultra-long cycling life.

A strong hydrogen bond bridging interface based on tannic acid for improving the performance of high-filled bamboo fibers/poly (butylene succinate-co-butylene adipate) (PBSA)biocomposites.

Natural plant fiber-reinforced bio-based polymer composites are widely attracting attention because of their economical, readily available, low carbon, and biodegradable, and showing promise in gradually replacing petroleum-based composites. Nevertheless, the fragile interfacial bonding between fiber and substrate hinders the progression of low-cost and abundant sustainable high-performance biocomposites. In this paper, a novel high-performance sustainable biocomposite was built by introducing a high density strong hydrogen-bonded bridging interface based on tannic acid (TA) between bamboo fibers (BFs) and PBSA. Through comprehensive analysis, this strategy endowed the biocomposites with better mechanical properties, thermal stability, dynamic thermo-mechanical properties and water resistance. The optimum performance of the composites was achieved when the TA concentration was 2 g/L. Tensile strength as well as modulus, flexural strength as well as modulus, and impact strength improved by 22 %, 10 %, 15 %, 35 %, and 25 % respectively. Additionally, the initial degradation temperature(Tonset) and maximum degradation temperature(Tmax) increased by 12.07 °C and 14.8 °C respectively. The maximum storage modulus(E'), room temperature E', and loss modulus(E")elevated by 199 %, 75 %, and 181 % respectively. Moreover, the water absorption rate decreased by 59 %. The strong hydrogen-bonded bridging interface serves as a novel model and theory for biocomposite interface engineering. At the same time, it offers a promising future for the development of high performance sustainable biocomposites with low cost and abundant biomass resources and contributes to their wide application in aerospace, automotive, biomedical and other field.

In-situ construction of chitosan@tannin structure on bamboo fiber for green and convenient reinforcement of poly(3-hydroxybutyrate) biocomposite.

Fiber-reinforced biocomposites were widely considered as the optimal sustainable alternative to traditional petroleum-based polymers due to their renewable, degradable, and environmentally friendly characteristics, along with economic benefits. However, the poor interfacial bonding between the matrix and natural fiber reinforcement remained a key issue limiting their mechanical and thermal properties. Focusing on cost-effective, convenient, and low-pollution chemical methods, this work proposed a strategy for in-situ synthesis of composite structures on bamboo fiber (BF) surfaces. Crude chitosan (CS) and reclaimed tannic acid (TA) were utilized as the raw materials, to construct stereo-netlike chitosan @ tannin structures (CS@TA) via a one-pot method facilitated by hydrogen bonding and complexation. The influence of reactant concentration and pH value on the process was further investigated and optimized. The CS@TA structure improved the interfacial bonding between the BF reinforcement and matrix poly(3-hydroxybutyrate) (PHB), and this non-amino-driven construction provided a potential reaction platform for functionalizing the interfacial layer. The modified biocomposite showed improvements in tensile and impact strengths (51.58 %, 41.18 %), also in tensile and flexural moduli (13.59 %, 26.88 %). Enhancements were also observed in thermal properties and heat capacity. This work presents a simple and promising approach to increase biocomposite interface bonding.

Flexible cellulose nanofiber aerogel with enhanced porous structure and its applications in copper(II) removal.

In order to achieve an aerogel with both rigid pore structures and desired flexibility, stiff carboxyl-functionalized cellulose nanofiber (CNFs) were introduced into a flexible polyvinyl alcohol-polyethyleneimine (PVA-PEI) crosslinking network, with 4-formylphenylboronic acid (4FPBA) bridging within the PVA-PEI network to enable dynamic boroxine and imine bond formation. The strong covalent bonds and hydrogen connections between CNF and the crosslinking network enhanced the wet stability of the aerogel while also contributed to its thermal stability. Importantly, the harmonious coordination between the stiff CNF and the flexible polymer chains not only facilitated aerogel flexibility but also enhanced its increased specific surface area by improving pore structure. Moreover, the inclusion of CNF enhanced the adsorption capacity of the aerogel, rendering it effective for removing heavy metal ions. The specific surface area and adsorption capacity for copper ions of the aerogel increased significantly with a 3 wt% addition CNF suspension, reaching 19.74 m2 g-1 and 60.28 mg g-1, respectively. These values represent a remarkable increase of 590.21 % and 213.96 %, respectively, compared to the blank aerogel. The CNF-enhanced aerogel in this study, characterized by its well-defined pore structures, and desired flexibility, demonstrates versatile applicability across multiple domains, including environmental protection, thermal insulation, electrode fabrication, and beyond.

Crustacean-inspired chitin-based flexible buffer layer with a helical cross-linked network for bamboo fiber/poly(3-hydroxybutyrate) biocomposites.

Marine biological resources, serving as a renewable and sustainable reservoir, holds significant import for the utilization of composite material. Hence, we produced bamboo fiber/poly(3-hydroxybutyrate) (BF/PHB) biocomposites with exceptional performance and economic viability, drawing inspiration from the resilience of crustacean shells. Polyaminoethyl modified chitin (PAECT) was synthesized using the alkali freeze-thaw method and introduced into the interface between BF and PHB to improve interfacial adhesion. The resulting chitin fibers, characterized by their intertwined helical chains, constructed a flexible mesh structure on the BF surface through an electrostatic self-assembly approach. The interwoven PAECT filaments infiltrated the dual-phase structure, acting as a promoter of interfacial compatibility, while the flexible chitin network provided a greater capacity for deformation accommodation. Consequently, both impact and tensile strength of the BF/PHB composites were notably enhanced. Additionally, this flexible layer ameliorated the thermal stability and crystalline properties of the composites. This investigation aimed to leverage the distinctive helical configuration of chitin to facilitate the advancement of bio-reinforced composites.

Mussel-inspired laccase-mediated polydopamine graft onto bamboo fibers and its improvement effect on poly(3-hydroxybutyrate) based biocomposite.

Bamboo fiber (BF) reinforced polyhydroxybutyrate (PHB) has become popular in developing an eco-friendly and sustainable biocomposite, while the weak interfacial compatibility between them is a major problem to overcome. This work, inspired by mussel super adhesion, creates a facile, highly efficient, and environmentally friendly solution based on in situ laccase-catalysed dopamine polymerization under a naturally acidic environment. The result indicates that a stabilized polydopamine coating is successfully grafted onto the lignin of BF, and it also enhances the thermal stability of the BF and biocomposite. Furthermore, modification of BF via laccase-catalysed polydopamine is superior to the conventional method of polydopamine under alkaline condition, and has outstanding advantages in terms of BF integrity protection. The optimal composition of biocomposite with BF treated by polydopamine under 1 U/mL concentration of laccase shows improvement in the impact strength, tensile strength, tensile modulus, bending strength, and modulus of elastic by 33.85 %, 9.27 %, 31.74 %, 11.76 %, and 12.92 %, respectively, compared to the unmodified counterpart. This work provides an insightful understanding of the mechanism and benefits of laccase-catalysed polydopamine modification of BF in a natural environment. It contributes to the efficient and environmentally friendly utilization of polydopamine for fabricating high-performance lignocellulosic fiber reinforced biocomposites.

Prediction of Scar Myometrium Thickness and Previous Cesarean Scar Defect Using the Three-Dimensional Vaginal Ultrasound.

This research aimed to explore the related factors of scar myometrial thickness and scar diverticulum formation and then predict the occurrence of uterine diverticula. 140 patients with cesarean section were selected as the research objects. According to the three-dimensional (3D) vaginal ultrasound echo and the diagnostic criteria of uterine diverticulum, the research objects were divided into a diverticulum group and a control group, with 70 cases in each group. Data such as age, number of cesarean sections, endometrial thickness, uterine position, and diverticulum size was collected, and their relationship with uterine diverticulum was compared and analyzed. The results showed that there were significant differences in menstrual days, cesarean section times, and uterine position between the two groups (P < 0.05). The height (9.02 ± 2.97), width (14.02 ± 3.08), and depth (5.14 ± 1.23) of the posterior uterine diverticula in the scar diverticulum group were all greater than the anterior uterine height (6.69 ± 1.36), the width (10.69 ± 2.15), and the depth (3.86 ± 0.69), respectively. The residual myometrium thickness in posterior position of the uterus (2.98 ± 0.75) was < anterior position of uterus (3.43 ± 0.47), and the difference was statistically significant (P < 0.05). Multivariate analysis showed that the frequency of cesarean section (1 time, 2 times), uterine position, and abnormal menstruation were independent risk factors in the scar diverticulum group (P < 0.05). In conclusion, menstrual abnormalities, the number of cesarean sections (1 time or twice), and the position of the uterus are independent risk factors for the formation of uterine scar diverticula. The deeper the diverticula, the more likely to have menstrual abnormalities, the more prone to diverticulum in patients with posterior uterus, and the deeper the diverticula in patients with 2 dissections.

Sulfosalicylic acid/Fe3+ based nanoscale coordination polymers for effective cancer therapy by the Fenton reaction: an inspiration for understanding the role of aspirin in the prevention of cancer.

Fenton reaction-based reactive oxygen species (ROS) generation provides a new idea for the design of ROS-mediated anticancer agents. Finding ways to increase iron uptake and to elevate the level of H2O2 in cells simultaneously is thus crucial to this strategy. Meanwhile, salicylic acid (SA) or its analogue, as the major metabolite of aspirin, has been reported to be closely associated with an intracellular redox-active product. In this work, a PEG-modified nanoscale coordination polymer (PFNC) via the self-assembly of 5-sulfosalicylic acid (SSA) with Fe3+ ions has been designed for the first time. The results show that the SSA dissociated from the PFNC can lead to the decrease of GSH and the accumulation of H2O2 in cancer cells, and thus elevate cellular ROS via the Fenton reaction. Owing to such intracellular oxidative stress, PFNC-induced ferroptotic cell death was further confirmed. In vitro cytotoxicity studies show that PFNCs display higher cytotoxicity on cancer cells than on normal cells. In vivo experiments further demonstrate that PFNCs not only possess high tumor accumulation, but also significantly inhibit the tumor growth without obvious damage toward the major organs. Based on the results, we expect that this work will provide an inspiration for understanding the role of SA, even aspirin, in the prevention of cancer.