Detalhe da pesquisa
1.
Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects.
J Virol
; 96(1): e0111021, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34668774
2.
Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model.
J Antimicrob Chemother
; 75(9): 2622-2632, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32464664
3.
Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30642924
4.
Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30833428
5.
Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.
Antimicrob Agents Chemother
; 59(12): 7743-52, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438502
6.
Pharmacokinetics/pharmacodynamics of a ß-lactam and ß-lactamase inhibitor combination: a novel approach for aztreonam/avibactam.
J Antimicrob Chemother
; 70(9): 2618-26, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26024868
7.
Evaluation of a panel of therapeutic antibody clinical candidates for efficacy against SARS-CoV-2 in Syrian hamsters.
Antiviral Res
; 213: 105589, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37003305
8.
Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Antimicrob Agents Chemother
; 56(3): 1240-6, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22183167
9.
SARS-CoV-2 BA.1 variant is neutralized by vaccine booster-elicited serum but evades most convalescent serum and therapeutic antibodies.
Sci Transl Med
; 14(645): eabn8543, 2022 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35380448
10.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
Antimicrob Agents Chemother
; 55(3): 1088-96, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21189350
11.
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.
Bioorg Med Chem Lett
; 21(24): 7416-20, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22041057
12.
SARS-COV-2 Delta variant displays moderate resistance to neutralizing antibodies and spike protein properties of higher soluble ACE2 sensitivity, enhanced cleavage and fusogenic activity.
bioRxiv
; 2021 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34790980
13.
SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.
Viruses
; 13(12)2021 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34960755
14.
SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster.
bioRxiv
; 2021 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34981057
15.
In Vivo Activity of Amodiaquine against Ebola Virus Infection.
Sci Rep
; 9(1): 20199, 2019 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882748
16.
Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus.
PLoS One
; 11(11): e0166318, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27902714
17.
Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
Biochim Biophys Acta
; 1699(1-2): 87-94, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15158715
18.
Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase.
Biochim Biophys Acta
; 1650(1-2): 105-16, 2003 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12922174
19.
Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
Biochim Biophys Acta
; 1700(1): 11-8, 2004 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15210120
20.
Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.
J Mol Biol
; 335(4): 905-21, 2004 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14698288