Cluster analysis of autoantibodies in 852 patients with systemic lupus erythematosus from a single center.

OBJECTIVE: Associations between autoantibodies and clinical features have been described in systemic lupus erythematosus (SLE). Herein, we aimed to define autoantibody clusters and their clinical correlations in a large cohort of patients with SLE. METHODS: We analyzed 852 patients with SLE who attended our clinic. Seven autoantibodies were selected for cluster analysis: anti-DNA, anti-Sm, anti-RNP, anticardiolipin (aCL) immunoglobulin (Ig)G or IgM, lupus anticoagulant (LAC), anti-Ro, and anti-La. Two-step clustering and Kaplan-Meier survival analyses were used. RESULTS: Five clusters were identified. A cluster consisted of patients with only anti-dsDNA antibodies, a cluster of anti-Sm and anti-RNP, a cluster of aCL IgG/M and LAC, and a cluster of anti-Ro and anti-La antibodies. Analysis revealed 1 more cluster that consisted of patients who did not belong to any of the clusters formed by antibodies chosen for cluster analysis. Sm/RNP cluster had significantly higher incidence of pulmonary hypertension and Raynaud phenomenon. DsDNA cluster had the highest incidence of renal involvement. In the aCL/LAC cluster, there were significantly more patients with neuropsychiatric involvement, antiphospholipid syndrome, autoimmune hemolytic anemia, and thrombocytopenia. According to the Systemic Lupus International Collaborating Clinics damage index, the highest frequency of damage was in the aCL/LAC cluster. Comparison of 10 and 20 years survival showed reduced survival in the aCL/LAC cluster. CONCLUSION: This study supports the existence of autoantibody clusters with distinct clinical features in SLE and shows that forming clinical subsets according to autoantibody clusters may be useful in predicting the outcome of the disease. Autoantibody clusters in SLE may exhibit differences according to the clinical setting or population.

Refractive errors of medical students in Turkey: one year follow-up of refraction and biometry.

PURPOSE: This study was conducted to determine the prevalence of refractive errors in Turkish medical students as well as to determine the change in refractive status of medical students within 1 year. Besides general refractive characteristics of the students, the possible relationship between the occurrence of myopia and several factors was also determined. METHODS: Two hundred and seven medical students (114 female/93 male) were checked for their refractive status as determined by cycloplegic autorefraction. In addition to keratometric and biometric measurements students also answered a detailed questionnaire. One year later, medical students who participated to the study were re-examined. RESULTS: Myopia occurred in 32.9% of medical students with low myopia (spherical equivalent between -0.75 diopters [D] and -2.99 D) being the most common type (81%). The frequency of myopia was not significantly different between female and male medical students (37.7 and 26.8%, respectively; p=0.13). Adult onset myopia (onset at age 18 years or older) comprised 14.7% of all myopia cases. Myopic students were significantly more likely to report parental myopia. The percentage of myopes and nonmyopes reporting having one or two myopic parents was 51.5 and 28.8%, respectively (p=0.002). Parental myopia was also an independent risk factor associated with the occurrence of myopia on multivariate analysis (odds ratio [OR]=3.69, 95% confidence interval [CI]=1.98-6.87). Nonmyopes also reported a significantly higher prevalence of outdoor activity before and at age seven (68.4%) than did myopes (48.6%), (p=0.009). Outdoor activity during early childhood was found to be protective for myopia on multivariate analysis (OR=0.44, %95 CI=0.23-0.82). There was no significant difference between myopes and nonmyopes with respect to amount of close-up activity. No significant shift of refraction occurred within 1 year. CONCLUSIONS: About one-third of Turkish medical students had myopia. Parental myopia was more common among myopic students and was a risk factor for the occurrence of myopia suggesting a familial predisposition. Outdoor activity in early childhood has had a protective role against the development of myopia in this study sample.