1.
J Org Chem
; 85(23): 14905-14915, 2020 12 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33124420
RESUMO
A novel method for the synthesis of ß-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.