Numerical simulation and in vitro experimental study of thrombus capture efficiency of a new retrievable vena cava filter.

The vena cava filter is a filtering device to prevent pulmonary embolism caused by thrombosis from lower limbs and pelvis. A new retrievable vena cava filter was evaluated in this paper. To evaluate the hemodynamic performance and thrombus capture efficiency after transplantation, numerical simulation of computational fluid dynamics was performed. In this paper, the two-phase flow model of computational fluid dynamics software was used to analyze the outlet blood flow velocity, inlet-outlet pressure difference, filter wall shear stress, the ratio of area with wall shear stress, and the thrombus capture efficiency with the thrombus diameter of 5 mm, 10 mm, 15 mm and the thrombus content of 10%, 20%, 30%, respectively. Additionally, in vitro experimental test was performed to compare its thrombus capture efficiency with Denali and Aegisy Filters. The Denali Filter showed the least interference with the blood flow, followed by the new filter and the Aegisy Filter. The results indicated that the new filter had a higher capture rate in capturing 5mm small-diameter thrombus. This research certain theoretical significance and reference value for the research and development of the new vena cava filters as well as the evaluation of the thrombus capture efficiency of the filters.

Analysis of Fatigue Strength and Reliability of Lower Limb Arterial Stent at Different Vascular Stenosis Rates and Stent-to-Artery Ratios.

In order to study the influence of different vascular stenosis rates and stent-to-artery ratios on the fatigue strength and reliability of lower limb arterial stents, numerical simulation was conducted for the fatigue strength of complete SE stents under pulsating loads using a finite element method. Then, fracture mechanics and conditional probability theory were adopted for mathematical modeling, whereby analyzing the crack growth rate and reliability with stents of different thickness (0.12, 0.15, and 0.18 mm) at different vascular stenosis rates (30, 50, and 70%) and stent-to-artery ratios (80, 85, and 90%). The study found: all three stents of different thickness failed to meet 10-year service life at three vascular stenosis rates; all three stents of different thickness met 10-year service life at three stent-to-artery ratios. With increased vascular stenosis rate, the elastic strain of stents was increased, while the fatigue strength was decreased; with increased stent-to-artery ratio, the elastic strain of the stent was increased, while the reliability of the stent was reduced. After the stent with an initial crack was implanted into the vessel, the crack length underwent non-linear growth with increased pulsating cyclic loads. When the pulsating load reached 3 × 108, the growth rate of the crack on the stent surface increased exponentially, leading to a rapid decrease in reliability. Vascular stenosis rate, stent release ratio, and support thickness have significant effects on crack length propagation rate and reliability. Determining the influence of vascular stenosis rate and stent-to-artery ratio on the fatigue strength and reliability of stents provides a valuable reference for evaluating the fracture failure rate and safety of stents.

Wheat GSPs and Processing Quality Are Affected by Irrigation and Nitrogen through Nitrogen Remobilisation.

The rheological properties and end-use qualities of many foods are mainly determined by the types and levels of grain storage proteins (GSPs) in wheat. GSP levels are influenced by various factors, including tillage management, irrigation, and fertiliser application. However, the effects of irrigation and nitrogen on GSPs remain unclear. To address this knowledge gap, a stationary split-split block design experiment was carried out in low- and high-fertility (LF and HF) soil, with the main plots subjected to irrigation treatments (W0, no irrigation; W1, irrigation only during the jointing stage; W2, irrigation twice during both jointing and flowering stages), subplots subjected to nitrogen application treatments (N0, no nitrogen application; N180, 180 kg/ha; N240, 240 kg/ha; N300, 300 kg/ha), and cultivars tested in sub-sub plots (FDC5, the strong-gluten cultivar Fengdecun 5; BN207, the medium-gluten cultivar Bainong 207). The results showed that GSP levels and processing qualities were significantly influenced by nitrogen application (p < 0.01), N240 was the optimal nitrogen rate, and the influence of irrigation was dependent on soil fertility. Optimal GSP levels were obtained under W2 treatment at LF conditions, and the content was increased by 17% and 16% for FDC5 and BN207 compared with W0 under N240 treatment, respectively. While the optimal GSP levels were obtained under W1 treatments at HF conditions, and the content was increased by 3% and 21% for FDC5 and BN207 compared with W0 under N240 treatment, respectively. Irrigation and nitrogen application increased the glutenin content by increasing Bx7 and Dy10 levels in FDC5, and by increasing the accumulation of Ax1 and Dx5 in BN207. Gliadins were mainly increased by enhancing α/ß-gliadin levels. Correlation analysis indicated that a higher soil nitrate (NO3-N) content increased nitrogen remobilisation in leaves. Path analysis showed that Dy10, Dx5, and γ-gliadin largely determined wet glutenin content (WGC), dough stability time (DST), dough water absorption rate (DWR), and sedimentation value (SV). Therefore, appropriate irrigation and nitrogen application can improve nitrogen remobilisation, GSP levels, and processing qualities, thereby improving wheat quality and production.

Analysis of Physiological Indicators Associated with Drought Tolerance in Wheat under Drought and Re-Watering Conditions.

Wheat (Triticum aestivum L.) production is severely threatened by an increase in the frequency of drought events. It is crucial to determine stable and effective morphological, physiological, and associated oxidative stress indicators, to evaluate the drought tolerance of wheat for breeding and cultivation. Therefore, the cultivars Luohan 22 (LH 22, drought-tolerant) and Zhengmai 366 (ZM 366, drought-sensitive) were used as experimental materials to analyze the changes in 12 physiological and biochemical indicators, as well as the yield, when the stress was prolonged to different times. Re-watering after 6 days of drought can effectively alleviate the associated oxidative stress of drought to wheat. The physiological responses of plants were reversible when they were re-watered in the range of 6 to 12 days after drought. The degree of recovery of LH 22 was higher than that of ZM 366. Afterwards, seven indicators, including stomatal conductance, proline, malondialdehyde, soluble sugar, hexokinase, glucose, and the non-photochemical quenching parameter, were screened out to characterize tolerance of wheat to drought using the multivariate statistical analytical method. This study further investigated the method of evaluating and indexing tolerance of wheat to drought, from the physiological and biochemical levels. This study can provide a theoretical basis and reference for the selection of wheat cultivars to breed and cultivate against drought stress.