Association Between Anesthesiologist Sex and Patients' Postoperative Outcomes: A Population-based Cohort Study.

OBJECTIVE: To examine the association of anesthesiologist sex on postoperative outcomes. BACKGROUND: Differences in patient postoperative outcomes exist, depending on whether the primary surgeon is male or female, with better outcomes seen among patients treated by female surgeons. Whether the intraoperative anesthesiologist's sex is associated with differential postoperative patient outcomes is unknown. METHODS: We performed a population-based, retrospective cohort study among adult patients undergoing one of 25 common elective or emergent surgical procedures from 2007 to 2019 in Ontario, Canada. We assessed the association between the sex of the intraoperative anesthesiologist and the primary end point of the adverse postoperative outcome, defined as death, readmission, or complication within 30 days after surgery, using generalized estimating equations. RESULTS: Among 1,165,711 patients treated by 3006 surgeons and 1477 anesthesiologists, 311,822 (26.7%) received care from a female anesthesiologist and 853,889 (73.3%) from a male anesthesiologist. Overall, 10.8% of patients experienced one or more adverse postoperative outcomes, of whom 1.1% died. Multivariable adjusted rates of the composite primary end point were higher among patients treated by male anesthesiologists (10.6%) compared with female anesthesiologists (10.4%; adjusted odds ratio 1.02, 95% CI: 1.00-1.05, P =0.048). CONCLUSIONS: We demonstrated a significant association between sex of the intraoperative anesthesiologist and patient short-term outcomes after surgery in a large cohort study. This study supports the growing literature of improved patient outcomes among female practitioners. The underlying mechanisms of why outcomes differ between male and female physicians remain elusive and require further in-depth study.

A matter of life and death: physician gender and patient outcomes after surgery.

Accumulating evidence supports an effect of physician gender (or sex, a surrogate used in many studies) on important patient outcomes such as death, complications, and hospital length of stay. Recent studies suggest that these effects result from the gender diversity of the team rather than individual physician gender. Here, we reflect on the potential mechanisms of an effect of physician gender on patient outcomes.

Association of chronic poststernotomy pain and health-related quality of life: a prospective cohort study.

PURPOSE: Chronic poststernotomy pain (CPSP) after cardiac surgery is multifactorial and impacts patient recovery. We aimed to evaluate the association between CPSP severity and health-related quality of life at six months after cardiac surgery. METHODS: This was a single-centre prospective cohort study of patients who underwent cardiac surgery with median sternotomy between September 2020 and March 2021. Telephone interviews were conducted at six and 12 months postoperatively using the Short Form McGill Pain Questionnaire and the EQ-5D-5L. Strength of correlation was described using Spearman's correlation coefficient. Multivariable regression analysis was used to account for confounding variables. RESULTS: A total of 252 patients responded to the six-month interview (response rate, 65%). The mean (standard deviation) age of respondents was 65 (13) yr. Twenty-nine percent of respondents (72/252) reported CPSP at six months, and 14% (41/252) reported more than mild pain (score ≥ 2/5). At 12 months, of the 89% (64/72) patients who responded, 47% (30/64) still reported pain. The strength of the correlation between pain scores and EQ-5D-5L was weak (Spearman's correlation coefficient, -0.3). Risk factors for CPSP at six months included higher pain score on postoperative day 1, history of chronic pain prior to surgery, and history of depression. Intraoperative infusion of dexmedetomidine or ketamine was associated with a reduced risk of CPSP at six months. CONCLUSION: Chronic poststernotomy pain still affects patient recovery at six and 12 months after cardiac surgery. The severity of that pain is poorly correlated with patients' quality of life. STUDY REGISTRATION: www.osf.io ( https://osf.io/52rsw ); registered 14 May 2022.

RéSUMé: OBJECTIF: La douleur chronique post-sternotomie (DCPS) après une chirurgie cardiaque est multifactorielle et a un impact sur le rétablissement des patient·es. Nous avons cherché à évaluer l'association entre la sévérité de la DCPS et la qualité de vie liée à la santé six mois après la chirurgie cardiaque. MéTHODE: Il s'agissait d'une étude de cohorte prospective monocentrique portant sur des patient·es ayant bénéficié d'une chirurgie cardiaque avec sternotomie médiane entre septembre 2020 et mars 2021. Des entrevues téléphoniques ont été menées à six et 12 mois après l'opération en se servant du questionnaire abrégé de McGill sur la douleur et de l'EQ-5D-5L. La force de corrélation a été décrite à l'aide du coefficient de corrélation de Spearman. Une analyse de régression multivariée a été utilisée pour tenir compte des variables confondantes. RéSULTATS: Au total, 252 patient·es ont répondu à l'entrevue à six mois (taux de réponse de 65 %). L'âge moyen (écart type) des répondant·es était de 65 (13) ans. Vingt-neuf pour cent des personnes répondantes (72/252) ont déclaré avoir été atteintes de DCPS à six mois, et 14 % (41/252) ont signalé une douleur plus que légère (score ≥ 2/5). À 12 mois, sur les 89 % (64/72) personnes ayant répondu, 47 % (30/64) signalaient encore de la douleur. La force de la corrélation entre les scores de douleur et l'EQ-5D-5L était faible (coefficient de corrélation de Spearman, −0,3). Les facteurs de risque de DCPS à six mois comprenaient un score de douleur plus élevé au jour 1 postopératoire, des antécédents de douleur chronique avant la chirurgie et des antécédents de dépression. Une perfusion peropératoire de dexmédétomidine ou de kétamine a été associée à une réduction du risque de DCPS à six mois. CONCLUSION: La douleur chronique post-sternotomie affecte toujours le rétablissement des patient·es six et 12 mois après la chirurgie cardiaque. La sévérité de cette douleur est faiblement corrélée à la qualité de vie des patient·es. ENREGISTREMENT DE L'éTUDE: www.osf.io ( https://osf.io/52rsw ); enregistrée le 14 mai 2022.

The Association Between Hospital High-volume Anesthesiology Care and Patient Outcomes for Complex Gastrointestinal Cancer Surgery: A Population-based Study.

OBJECTIVE: To examine the association of between hospital rates of high-volume anesthesiology care and of postoperative major morbidity. BACKGROUND: Individual anesthesiology volume has been associated with individual patient outcomes for complex gastrointestinal cancer surgery. However, whether hospital-level anesthesiology care, where changes can be made, influences the outcomes of patients cared at this hospital is unknown. METHODS: We conducted a population-based retrospective cohort study of adults undergoing esophagectomy, pancreatectomy, or hepatectomy for cancer from 2007 to 2018. The exposure was hospital-level adjusted rate of high-volume anesthesiology care. The outcome was hospital-level adjusted rate of 90-day major morbidity (Clavien-Dindo grade 3-5). Scatterplots visualized the relationship between each hospital's adjusted rates of high-volume anesthesiology and major morbidity. Analyses at the hospital-year level examined the association with multivariable Poisson regression. RESULTS: For 7893 patients at 17 hospitals, the rates of high-volume anesthesiology varied from 0% to 87.6%, and of major morbidity from 38.2% to 45.4%. The scatter plot revealed a weak inverse relationship between hospital rates of high-volume anesthesiology and of major morbidity (Pearson: -0.23). The adjusted hospital rate of high-volume anesthesiology was independently associated with the adjusted hospital rate of major morbidity (rate ratio: 0.96; 95% CI, 0.95-0.98; P <0.001 for each 10% increase in the high-volume rate). CONCLUSIONS: Hospitals that provided high-volume anesthesiology care to a higher proportion of patients were associated with lower rates of 90-day major morbidity. For each additional 10% patients receiving care by a high-volume anesthesiologist at a given hospital, there was an associated reduction of 4% in that hospital's rate of major morbidity.

Outcomes of COVID-19 manuscripts submitted to the Canadian Journal of Anesthesia: a retrospective audit of author gender and person of colour status.

PURPOSE: We aimed to evaluate the representation of women and persons of colour (POC) authors of COVID-19 manuscripts submitted to, accepted in, and rejected from the Journal and to evaluate trends in their representation during the pandemic. METHODS: All COVID-19 manuscripts submitted to the Journal between 1 February 2020 and 30 April 2021 were included. Manuscript data were retrieved from Editorial Manager, and gender and POC status were obtained through: 1) e-mail communication with corresponding authors; 2) e-mail queries to other coauthors; 3) NamSor software, and 4) Internet searches. The data were described using percentages and summary statistics. A two-sample test of proportions was used for comparisons and trends were analyzed with linear regression. RESULTS: We identified 314 manuscripts (1,555 authors), 95 (461 authors) of which were accepted for publication. Of all authors, 515 (33%) were women, and women were the lead and senior authors of 101 (32%) and 69 (23%) manuscripts, respectively. There were no differences in women's representation as authors between accepted and rejected manuscripts. Overall, 923/1,555 (59%) authors were identified as POC, with a significantly lower proportion of POC authors among accepted vs rejected manuscripts (41%, 188/461 vs 67%, 735/1,094; difference, -26%; 95% CI, -32 to -21; P < 0.001). We did not observe significant trends in the proportion of women and POC authors over the study period. CONCLUSION: The proportion of women authors of COVID-19 manuscripts was lower than men's representation. Further research is required to determine the factors that account for the higher proportion of POC authors across rejected manuscripts.

RéSUMé: OBJECTIF: Nous avions pour objectif d'évaluer la représentation des femmes et des personnes de couleur ayant rédigé des manuscrits portant sur la COVID-19 soumis, acceptés et rejetés au Journal et d'évaluer les tendances concernant leur représentation pendant la pandémie. MéTHODE: Tous les manuscrits portant sur la COVID-19 soumis au Journal entre le 1er février 2020 et le 30 avril 2021 ont été inclus. Les données des manuscrits ont été extraites de la plateforme de gestion des manuscrits Editorial Manager, et le sexe et le statut de personne de couleur ont été obtenus par : 1) la communication par courrier électronique avec les auteurs et autrices correspondant·es; 2) des requêtes par courrier électronique envoyées à d'autres coautrices et coauteurs; 3) le logiciel NamSor, et 4) des recherches sur Internet. Les données ont été décrites à l'aide de pourcentages et de statistiques sommaires. Un test de proportions à deux échantillons a été utilisé pour les comparaisons et les tendances ont été analysées par régression linéaire. RéSULTATS: Nous avons identifié 314 manuscrits (1555 auteurs et autrices), dont 95 (461 autrices et auteurs) ont été acceptés pour publication. Parmi tou·tes les auteurs/autrices, 515 (33 %) étaient des femmes, et les femmes étaient les autrices principales et senior de 101 (32 %) et 69 (23 %) manuscrits, respectivement. Il n'y avait aucune différence dans la représentation des femmes en tant qu'autrices entre les manuscrits acceptés et rejetés. Dans l'ensemble, 923/1555 (59 %) auteurs et autrices ont été identifié·es comme étant des personnes de couleur, avec une proportion significativement plus faible d'autrices et d'auteurs de couleur parmi les manuscrits acceptés vs rejetés (41 %, 188/461 vs 67 %, 735/1094; différence, -26 %; IC 95 %, -32 à -21; P < 0,001). Nous n'avons pas observé de tendances significatives dans la proportion d'auteurs et d'autrices femmes et de couleur au cours de la période à l'étude. CONCLUSION: La proportion de femmes autrices de manuscrits sur la COVID-19 était inférieure à celle des hommes. D'autres recherches sont nécessaires pour déterminer les facteurs qui expliquent la plus grande proportion d'autrices et d'auteurs de couleur parmi les manuscrits rejetés.

Perioperative cortical hand stroke syndrome mimicking peripheral neuropathy: a case report.

PURPOSE: Timely diagnosis of perioperative stroke is challenging, and therapeutic interventions are infrequently offered. The cortical hand syndrome is a rare stroke presentation that results from infarction of the precentral gyrus leading to variable neurologic deficits mimicking peripheral nerve injuries, with no prior reports in the perioperative setting. To raise awareness of this complication among anesthesiologists, we present a case of cortical hand syndrome in a surgical patient initially suspected to have a peripheral neuropathy. CLINICAL FEATURES: A 68-yr-old male with multiple stroke risk factors underwent a nephroureterectomy under general anesthesia and thoracic epidural analgesia for urothelial carcinoma. The patient noted right-hand numbness and weakness to digits 3-5 immediately after surgery and notified his bedside nurse the following day. His symptoms were initially presumed to be a peripheral neuropathy secondary to surgical positioning. Computed tomography of the head the following day revealed an acute cortical infarct in the precentral gyrus consistent with cortical hand stroke syndrome. Subsequent neurologic consultation revealed additional subtle right-sided weakness. Further workup revealed moderate (60-80%) stenosis of the left carotid artery and he underwent a successful carotid endarterectomy one week later. His symptoms had mostly resolved six weeks later. CONCLUSION: Cortical hand stroke syndrome is a rare presentation of perioperative stroke that may be misdiagnosed as a peripheral neuropathy. Our case presentation highlights that perioperative stroke should be considered for patients presenting with neurologic deficits of the hand, particularly those with deficits in multiple peripheral nerve territories and stroke risk factors.

RéSUMé: OBJECTIF: Le diagnostic rapide de l'accident vasculaire cérébral (AVC) périopératoire est difficile, et les interventions thérapeutiques sont rarement proposées. Le syndrome de la main corticale est une présentation rare de l'AVC qui résulte d'un infarctus du gyrus précentral entraînant des déficits neurologiques variables imitant les lésions nerveuses périphériques, sans avoir été préalablement rapporté dans le cadre périopératoire. Afin de sensibiliser les anesthésiologistes à cette complication, nous présentons un cas de syndrome de la main corticale chez un patient chirurgical chez lequel une neuropathie périphérique était initialement suspectée. CARACTéRISTIQUES CLINIQUES: Un homme de 68 ans présentant de multiples facteurs de risque d'AVC a subi une néphro-urétérectomie sous anesthésie générale et une analgésie péridurale thoracique pour un carcinome urothélial. Le patient a remarqué un engourdissement et une faiblesse de la main droite du majeur à l'auriculaire immédiatement après la chirurgie et a avisé le personnel infirmier à son chevet le lendemain. On a d'abord présumé que ses symptômes indiquaient une neuropathie périphérique secondaire au positionnement chirurgical. La tomodensitométrie de la tête réalisée le lendemain a révélé un infarctus cortical aigu dans le gyrus précentral, compatible avec un syndrome d'AVC de la main corticale. Une consultation neurologique ultérieure a révélé une faiblesse subtile supplémentaire du côté droit. Un examen plus approfondi a révélé une sténose modérée (60 à 80 %) de l'artère carotide gauche et le patient a bénéficié d' une endartériectomie carotidienne réussie une semaine plus tard. Ses symptômes avaient pour la plupart disparu six semaines plus tard. CONCLUSION: Le syndrome de l'AVC de la main corticale est une présentation rare d'AVC périopératoire qui peut être diagnostiqué à tort comme une neuropathie périphérique. Notre présentation de cas souligne que l'AVC périopératoire devrait être envisagé chez les patient·es présentant des déficits neurologiques de la main, en particulier chez les personnes présentant des déficits dans plusieurs territoires nerveux périphériques et des facteurs de risque d'AVC.

Anesthetic consideations for endovascular treatment of acute ischemic stroke.

PURPOSE: The purpose of this Continuing Professional Development module is to provide information pertaining to anesthetic considerations and management of endovascular thrombectomy (EVT) for patients with acute ischemic stroke. PRINCIPAL FINDINGS: Acute ischemic stroke is a devastating neurologic disorder and timely intervention is key to a good neurologic outcome. This article provides an overview of three important concepts: pathophysiology and disease characteristics of acute ischemic stroke, and the procedural and anesthetic aspects of EVT. Key considerations include recognition of stroke symptoms, timing and urgency of intervention, procedural considerations for anesthesiologists, risks and benefits of different anesthetic techniques, and a summary of recent guidelines. In particular, current recommendations for blood pressure management in this setting are reviewed. CONCLUSIONS: Timely intervention for patients with acute ischemic stroke is of utmost importance. Endovascular thrombectomy is a minimally invasive procedure that has evolved over recent decades and improves outcomes for selected patients with ischemic stroke. Anesthesiologists should have a good understanding of potential complications and anesthetic options. Recent randomized trials have shown that both general anesthesia and sedation are associated with good outcomes; the anesthetic approach should be individualized and may vary by institution. Careful monitoring and maintenance of hemodynamic goals are critical, as is effective communication with the multidisciplinary team.

RéSUMé: OBJECTIF: L'objectif de ce module de développement professionnel continu est de fournir des informations sur les considérations anesthésiques et la prise en charge de la thrombectomie endovasculaire (TEV) chez les patients atteints d'AVC ischémique aigu. CONSTATATIONS PRINCIPALES: L'AVC ischémique aigu est un trouble neurologique dévastateur; une intervention rapide est la clé d'un bon devenir neurologique. Cet article donne un aperçu de plusieurs concepts importants : la physiopathologie et les caractéristiques pathologiques de l'AVC ischémique aigu, ainsi que les aspects procéduraux et anesthésiques de la TEV. Les principales considérations comprennent la reconnaissance des symptômes de l'AVC, le moment et l'urgence de l'intervention, les considérations procédurales pour les anesthésiologistes, les risques et les avantages des différentes techniques d'anesthésie, et un résumé des lignes directrices récentes. Plus spécifiquement, nous passerons en revue les recommandations actuelles pour la prise en charge de la pression artérielle dans un tel contexte. CONCLUSIONS: Une intervention rapide est essentielle pour les patients atteints d'AVC ischémique aigu. La thrombectomie endovasculaire est une procédure minimalement invasive qui a évolué au cours des dernières décennies et qui améliore les devenirs de certains patients atteints d'AVC ischémique. Les anesthésiologistes doivent avoir une bonne compréhension des complications potentielles et des options anesthésiques. Des études randomisées récentes ont montré que l'anesthésie générale et la sédation sont associées à de bons pronostics; l'approche anesthésique devrait être personnalisée et peut varier d'un établissement à l'autre. Un monitorage attentif et le maintien des cibles hémodynamiques sont essentiels, tout comme une communication efficace avec l'équipe multidisciplinaire.

Women in anaesthesia: a scoping review.

Despite an increase in the proportion of women anaesthesiologists over time, women remain under-represented in academic and leadership positions, honour awards, and academic promotion. Current literature has identified several reasons for the observed gender disparity in anaesthesiology leadership and faculty positions, including unsupportive work environments, lack of mentorship, personal choices, childcare responsibilities, and active discrimination against women. A scoping review design was selected to examine the nature and extent of available research. Our review provides an overview of the literature that explores gender issues in anaesthesiology, identifies gaps in the literature, and appraises effective strategies to improve gender equity in anaesthesiology. We searched PubMed, MEDLINE, and EMBASE up to July 2019, and included 30 studies for analysis. Most reports used retrospective or survey methodologies. The review shows that women anaesthesiologists face gender biases in the work environment, are under-represented in various positions of leadership or influence, and as authors. Work-life demands may impose a challenge. Motivation and interest in career advancement of women anaesthesiologists have not been well studied. Several strategies have been proposed, ranging from an individual to administrative level, which may help anaesthesiologists achieve equal representation of women in the field.

Women anesthesiologists' journeys to academic leadership: a constructivist grounded theory-inspired study.

BACKGROUND: Women continue to be underrepresented in academic anesthesiology, especially in leadership positions. Possible reasons for this gender disparity include family responsibilities, inadequate mentorship, lack of desire for leadership, the leaky pipeline effect (i.e., attrition of women physicians over the course of their career trajectories), and discrimination. Our objective was to understand the lived experiences of Canadian anesthesiologists in leadership positions. METHODS: In this constructivist grounded theory-inspired study, we used purposeful sampling to identify women anesthesiologists in leadership positions at one Canadian institution. Each participant underwent a one-on-one semi-structured interview of 40-60 min in length, sampling until theoretical saturation was reached. We included questions about the participant's practice setting, influences on their career, and advice the participant would provide to other women in leadership. We used an iterative approach to theoretical sampling and data analysis. The audio-recorded semi-structured interviews were transcribed and coded. NVivo12 was used for open and axial coding, and cross-referencing. RESULTS: Eight women anesthesiologists were recruited and interviewed. Our iterative process identified four interconnected themes: difficulty internalizing a leadership identity, identifying systemic barriers and biases, dissonance between agentic traits and communal social gender roles, and mentorship as shaping lived experiences. Participants consistently expressed experiencing discrimination, articulated barriers related to family responsibilities and ingrained societal expectations, and discussed how typical leadership traits are applied differently to women and men. Women perceived themselves as more compassionate and communicative than men. Despite these traits, these women have expressed barriers to obtaining mentorship. CONCLUSION: We identified consistent interconnected themes among the experiences of our sample of women anesthesiologists in academic leadership and found that academic anesthesiology is a gendered profession as experienced by these women leaders. Further research should focus on strategies to remove barriers to participation in academic anesthesiology for women.

RéSUMé: CONTEXTE: Les femmes continuent d'être sous-représentées en anesthésiologie académique, et tout particulièrement dans les positions de leadership. Parmi les raisons expliquant cette disparité entre les sexes, citons les responsabilités familiales, un mentorat inadapté, le manque de désir de leadership, l'effet de tuyau percé (soit l'attrition des femmes médecins au cours de leur parcours professionnel) et la discrimination. Notre objectif était de comprendre les expériences vécues par les anesthésiologistes canadiennes en position de leadership. MéTHODE: Dans cette étude inspirée de la théorie ancrée constructiviste ('constructivist grounded theory'), nous avons utilisé un échantillonnage ciblé afin d'identifier les femmes anesthésiologistes en position de leadership dans un établissement canadien. Chaque participante a pris part à un entretien semi-structuré privé de 40-60 minutes, soit jusqu'à atteindre une saturation théorique. Nous avons inclus des questions concernant le cadre de pratique des participantes, les influences sur leur carrière, et les conseils qu'elles donneraient à d'autres femmes en position de leadership. Nous avons utilisé une approche itérative pour l'échantillonnage théorique et l'analyse de données. Un enregistrement sonore des entretiens semi-structurés a été réalisé pour être ensuite retranscrit et codé. Le progiciel NVivo12 a été utilisé pour le codage ouvert et axial ainsi que pour le référencement croisé. RéSULTATS: Huit femmes anesthésiologistes ont été recrutées et interviewées. Notre processus itératif nous a permis d'identifier quatre thèmes interconnectés : la difficulté d'internaliser une identité de leader, l'identification d'obstacles et de biais systémiques, la dissonance entre l'agentivité individuelle et les rôles de genre socialement construits, et le mentorat en tant que formatif des expériences vécues. Les participantes ont toutes exprimé ressentir de la discrimination, elles ont articulé des obstacles liés aux responsabilités familiales et aux attentes sociétales enracinées, et ont expliqué comment les caractéristiques typiques de leadership étaient appliquées différemment selon le sexe. Les femmes se percevaient comme étant plus empathiques et communicatives que les hommes. Malgré ces traits de caractère, ces femmes ont exprimé qu'il existait des obstacles à l'obtention de mentorat. CONCLUSION: Nous avons identifié plusieurs thèmes interconnectés récurrents parmi les expériences de notre échantillonnage de femmes anesthésiologistes dans des positions de leadership académique et observé que l'anesthésiologie en milieu académique est une profession genrée, comme l'ont ressenti ces femmes leaders. Les recherches futures devraient mettre l'accent sur des stratégies visant à déjouer les obstacles à la participation des femmes en anesthésiologie académique.

Representation of women amongst speakers at the Canadian Anesthesiologists' Society annual meeting: a retrospective analysis from 2007 to 2019.

PURPOSE: Despite an increase in the proportion of women entering the field of anesthesiology, women remain underrepresented in academic and leadership positions. Speaking at national and international conferences is an important component of academic visibility and promotion. To date, the gender representation of speakers at the Canadian Anesthesiologists' Society (CAS) annual meeting has not been examined. METHODS: We conducted a retrospective analysis of the representation of women amongst speakers at the CAS annual meeting between 2007 and 2019, inclusively. We also examined the representation of women in different subspecialty subject area symposia at each CAS annual meeting, and the gender composition of meeting symposia panels (i.e., groups of two or more speakers in a session) at the meeting. RESULTS: Overall, 28.5% (358/1,256) of speaker slots included women, similar to their representation in Canadian clinical anesthesiology over the study period (26.7%), and increasing significantly over the study period. Women were more highly represented as obstetric anesthesia speakers at the CAS annual meetings, with lower representation in cardiothoracic anesthesia, transplant anesthesia, and critical care symposia. Of the 311 meeting symposia, 146 (46%) were composed of all men speakers. CONCLUSION: The representation of women speakers at the CAS annual meeting was similar to the representation of women in the anesthesiology workforce in Canada over the study period. Gender representation varied widely by subspecialty symposia, subject area, and women were absent from nearly half of all symposia at the CAS annual meetings, which are potential areas of future investigation and intervention.

Knowledge and perceptions about perioperative stroke: a cross-sectional survey of patients scheduled for non-neurologic and non-cardiac surgery.

PURPOSE: Perioperative stroke is associated with significant morbidity and mortality yet patients may not be aware of their risk or receive appropriate counselling. Our objectives were to 1) compare patient's perceived vs calculated risk of stroke; 2) determine level of worry; and 3) assess prior discussion about perioperative stroke risk amongst elective patients undergoing non-cardiac, non-neurologic surgery. METHODS: Over a consecutive four-week period, surveys were distributed at two pre-anesthetic clinics to adult patients scheduled for non-cardiac, non-neurologic surgery. The survey included questions about demographics, perioperative stroke risk factors, patient perception of their quantitative and qualitative stroke risk, level of worry about stroke, and risk discussions. We identified independent predictors of risk underestimation amongst medium- and high-risk patients. RESULTS: Six hundred patients completed the survey (response rate 78%). Of these, 479, 104, and 15 patients were classified as low-, medium-, and high-risk, respectively (with two patients missing this data point). Most medium- (86%) and high-risk (80%) patients did not identify their elevated risk. Amongst medium- and high-risk patients, independent predictors of risk underestimation were lower education and absence of kidney disease. Medium- and high-risk patients were more worried than low-risk patients about perioperative stroke (median [interquartile range] visual analogue scale score 2 [0.5-4] vs 1 [0-2], P = 0.001). Fewer than half of patients had discussed perioperative stroke previously (40%, 23%, and 12% of high-, medium-, and low-risk patients, respectively). CONCLUSIONS: Patients at higher risk of stroke frequently underestimate their risk of perioperative stroke. The majority of patients had not discussed perioperative stroke prior to anesthetic consultation.

Representation of female authors in the Canadian Journal of Anesthesia: a retrospective analysis of articles between 1954 and 2017.

PURPOSE: Females remain under-represented in academic anesthesiology. Our objectives were to investigate gender differences over time in the first and last authors of published articles as well as corresponding citation rates in the Canadian Journal of Anesthesia (CJA). METHODS: We conducted a cross-sectional, retrospective analysis of first and last authors' gender from editorials and original articles published in the CJA in a sample of one calendar year of each decade between 1954 to 2017. We analyzed the relationships between author gender, year of publication, article type, and number of citations. RESULTS: Out of 639 articles identified, 542 (85%) were original investigations and 97 (15%) were editorials. Where gender could be confidently identified, the majority (461/571, 81%) of first authors were male. Although there was an increase in the proportion of female first authors over time, this increase was outpaced by the overall increase in female anesthesiologists in Canada. Original articles received more citations and were more likely to have a female first author than editorial articles were. An original article with a female first author resulted in 0.34 (95% confidence interval, 0.28 to 0.39; P < 0.001) more citations per article than a male first author when adjusting for year of publication. CONCLUSIONS: Our study shows that, despite a slow increase over time, female authors are under-represented relative to male authors in the CJA and relative to the changing demographics of anesthesiologists in Canada. The reasons for this disparity are multifactorial and further research is needed to identify effective solutions.

RéSUMé: OBJECTIF: Les femmes restent sous-représentées dans le monde de l'anesthésiologie universitaire. Nos objectifs étaient d'étudier l'évolution des premiers et derniers auteurs en fonction du sexe au fil des années dans les articles publiés ainsi que les taux correspondants de citation dans le Journal canadien d'anesthésie (CJA). MéTHODES: Nous avons mené une analyse transversale rétrospective du sexe des premiers et derniers auteurs des éditoriaux et des articles originaux publiés dans le CJA dans un échantillon d'une année civile pour chaque décennie entre 1954 et 2017. Nous avons analysé les rapports entre le sexe des auteurs, l'année de publication, le type d'articles et le nombre de citations. RéSULTATS: Sur 639 articles identifiés, 542 (85 %) étaient des recherches originales et 97 (15 %) étaient des éditoriaux. Lorsque le sexe a pu être identifié avec certitude, la majorité des premiers auteurs (461/571, 81 %) étaient des hommes. Bien qu'il y ait eu une augmentation du pourcentage de femmes premières auteures au fil du temps, cette augmentation n'a pas suivi la progression du nombre global des femmes anesthésiologistes au Canada. Les articles originaux ont été cités plus souvent et ont été plus susceptibles d'avoir un premier auteur féminin que les éditoriaux. Après ajustement pour l'année de publication, un article original dont le premier auteur était une femme comptait 0,34 (intervalle de confiance à 95 %, 0,28 à 0,39; P < 0,001) fois plus de citations que lorsque le premier auteur était un homme. CONCLUSIONS: Notre étude montre que, malgré une lente augmentation avec les années, les femmes auteures sont sous-représentées par rapport à leurs collègues masculins dans le CJA et par rapport aux changements démographiques de l'anesthésiologie au Canada. Les raisons de cette disparité sont multifactorielles et d'autres recherches sont nécessaires pour trouver des solutions efficaces.

'After-hours' non-elective spine surgery is associated with increased perioperative adverse events in a quaternary center.

PURPOSE: 'After-hours' non-elective spinal surgeries are frequently necessary, and often performed under sub-optimal conditions. This study aimed (1) to compare the characteristics of patients undergoing non-elective spine surgery 'After-hours' as compared to 'In-hours'; and (2) to compare the perioperative adverse events (AEs) between those undergoing non-elective spine surgery 'after-hours' as compared to 'in-hours'. METHODS: In this retrospective study of a prospective non-elective spine surgery cohort performed in a quaternary spine center, surgery was defined as 'in-hours' if performed between 0700 and 1600 h from Monday to Friday or 'after-hours' if more than 50% of the operative time occurred between 1601 and 0659 h, or if performed over the weekend. The association of 'after-hours' surgery with AEs, surgical duration, intraoperative estimated blood loss (IOBL), length of stay and in-hospital mortality was analyzed using stepwise multivariate logistic regression. RESULTS: A total of 1440 patients who underwent non-elective spinal surgery between 2009 and 2013 were included in this study. A total of 664 (46%) procedures were performed 'after-hours'. Surgical duration and IOBL were similar. About 70% of the patients operated 'after-hours' experienced at least one AE compared to 64% for the 'in-hours' group (p = 0.016). 'After-hours' surgery remained an independent predictor of AEs on multivariate analysis [adjusted OR 1.30, 95% confidence interval (CI) 1.02-1.66, p = 0.034]. In-hospital mortality increased twofold in patients operated 'after-hours' (4.4% vs. 2.1%, p = 0.013). This association lost significance on multivariate analysis (adjusted OR 1.99, 95% CI 0.98-4.06, p = 0.056). CONCLUSION: Non-elective spine surgery performed 'after-hours' is independently associated with increased risk of perioperative adverse events, length of stay and possibly, mortality. Research is needed to determine the specific factors contributing to poorer outcomes with 'after-hours' surgery and strategies to minimize this risk. These slides can be retrieved under Electronic Supplementary Material.

Neuroanesthesia and outcomes: evidence, opinions, and speculations on clinically relevant topics.

PURPOSE OF REVIEW: The objective of this review is to identify outstanding topics most relevant to neuroanesthesia practice and patient outcomes. We discuss the role of awake craniotomy, choice of general anesthetic agents, monitoring of anesthetic 'depth', mannitol-induced diuresis, neurophysiological monitoring, hyperventilation, and cerebral hypoperfusion. RECENT FINDINGS: Awake craniotomy, although a technique likely underused, is associated with enhanced recovery after surgery and prolonged survival after brain tumor resection compared with surgery under general anesthesia. The choice of general anesthetic must balance patient and surgical factors. Although propofol may be associated with favorable oncologic outcomes, currently available retrospective evidence does not specifically address neurosurgical patients. Both the definition and monitoring of anesthetic 'depth' remains elusive. Neuroanesthesiologists need to recognize and manage intraoperative light anesthesia in a timely fashion. Further evidence related to the optimal management of mannitol-induced diuresis and hyperventilation in neurosurgical patients is needed. Contemporary neurophysiological monitoring can reasonably detect intraoperative neurologic injury; however, its effect on patient outcome is unclear. Finally, cerebral hypoperfusion without stroke may be common; however, the clinical significance requires further investigation. SUMMARY: We provide an overview of several topics that are relevant to neuroanesthesia practice and patient outcomes based on evidence, opinions, and speculations. Our review highlights the need for further outcome-oriented studies to specifically address these clinically relevant issues.

The impact of frailty and sarcopenia on patient outcomes after complex spine surgery.

PURPOSE OF REVIEW: Frailty and sarcopenia represent a state of increased fragility and decreased reserve, and both have been associated with worse outcomes after surgery. The present review focuses on the definitions and measurement tools used to assess frailty and sarcopenia in patients with spinal disorder, and the relationships between frailty, sarcopenia, and postoperative outcomes in patients undergoing complex spine surgery. RECENT FINDINGS: Complex spine surgery is associated with a high rate of adverse events when using a validated, prospective data collection system. Recent studies have demonstrated that patients with spine surgery with frailty and sarcopenia have a higher risk of adverse events, although this relationship varies depending on the measurement tool and specific population studied. Both general and specific frailty assessment tools have been used in the spine surgery population, however the optimal tool is not known. Spinal disorders such as lumbar stenosis contribute to the frailty phenotype, and may be reversible with surgery. SUMMARY: Frailty and sarcopenia are increasingly recognized as important predictors of adverse outcomes after complex spine surgery. The optimal tool to measure frailty and sarcopenia in patients with spinal disorders remains unclear, and the role of surgery as an intervention to reverse frailty requires further investigation.

Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation.

BACKGROUND: The depth of dexmedetomidine-induced sedation is difficult to assess without arousing the patient. We evaluated frontal electroencephalogram (EEG) as an objective measure of dexmedetomidine-induced sedation. Our aims were to characterize the response patterns of EEG during a wide range of dexmedetomidine-induced sedation and to determine which spectral power best correlated with assessed levels of dexmedetomidine-induced sedation. METHODS: Sedline EEG sensor was positioned on the forehead of 16 volunteers. Frontal EEG data were collected at 250 Hz using the Sedline monitor. A computer-controlled infusion pump was used to infuse dexmedetomidine to four 15-minute target plasma concentrations of 0.3, 0.6, 1.2, and 2.4 ng/mL. Arterial blood samples for dexmedetomidine plasma concentration and sedation (self-reported numerical rating scale) and arousal were measured at baseline and at the end of each infusion step. The EEG signal was used to estimate spectral power in sequential 4-second data segments with 75% overlap for 3 power bands: delta = 0.5-1.5 Hz, alpha = 9-14 Hz, beta = 15-24 Hz. We quantified the relationships among the plasma concentrations of dexmedetomidine, level of sedation, and various EEG parameters. RESULTS: EEG data at the end of the dexmedetomidine infusion steps show progressive loss of high frequencies (beta) and increase in alpha and delta powers, with increasing dexmedetomidine concentrations. Beta prearousal spectral power was best in predicting dexmedetomidine-induced level of sedation (R = -0.60, 95% CI, -0.43 to -0.75). The respective values for delta and alpha powers were R = 0.28 (95% CI, 0.03-0.45) and R = 0.16 (95% CI, -0.09 to 0.38). When the beta power has dropped below -16 dB or the delta power is above 15 dB, the subjects show moderate to deep levels of sedation. When awakening the subject, there is a reduction in power in the delta and alpha bands at the 0.6, 1.2, and 2.4 ng/mL dexmedetomidine target levels (P < .001 for all). In beta band, there is a rapid awakening-induced increase in power (P < .001) followed by a slow return toward baseline values. After arousing the subjects, the EEG powers returned toward baseline values significantly slower than our clinical observation of the subjects' wakefulness would have suggested. CONCLUSIONS: Using a wide range of dexmedetomidine doses, we found that frontal EEG beta power of less than -16 dB and/or a delta power of over 15 dB was associated with a state of moderate to deep sedation and that poststimulus return of EEG powers toward baseline values took significantly longer than expected from observation of the arousal response. It is unclear whether these observations are robust enough for clinical applicability.

Accuracy and Reliability of Internet Resources for Information on Idiopathic Pulmonary Fibrosis.

RATIONALE: Patients commonly use the Internet as a resource for health information; however, no studies have evaluated the online information about idiopathic pulmonary fibrosis (IPF). OBJECTIVES: We sought to determine the readability, content (compared with established guidelines), bias, and quality of online IPF resources. METHODS: We analyzed the first 200 hits for "idiopathic pulmonary fibrosis" in Google, Yahoo, and Bing. Each website was evaluated for content related to IPF features and treatments that are discussed in clinical guidelines. Website quality was assessed using the validated DISCERN instrument. MEASUREMENTS AND MAIN RESULTS: Eligibility criteria were met in 181 websites. The median reading grade level was 12. More content was provided in scientific resources (academic institutions or governmental organizations) and foundation/advocacy organization sites than in personal commentary (blog) sites; however, most sites provided incomplete and/or inaccurate information. Nonindicated and/or harmful pharmacotherapies for IPF were described as potential IPF treatments in 48% of websites and were most often recommended in foundation/advocacy organization websites. Azathioprine and corticosteroids were discussed as potential chronic treatments of IPF in 13.3 and 30.6% of the 98 websites that had been updated after publication of data demonstrating harm from these medications. Website quality (DISCERN score) was poor in all site types but was worse in news/media reports and personal commentary (blog) sites than in sites from scientific and foundation/advocacy organizations. CONCLUSIONS: Patient-directed online information on IPF is frequently incomplete, inaccurate, and outdated. There is no reliable method for patients to identify sites that provide appropriate information on IPF.