Detalhe da pesquisa
1.
Functional assessment of homozygous ALDH18A1 variants reveals alterations in amino acid and antioxidant metabolism.
Hum Mol Genet
; 32(5): 732-744, 2023 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36067040
2.
Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth.
J Biol Chem
; 298(10): 102407, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35988653
3.
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
J Am Chem Soc
; 144(41): 18861-18875, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36200994
4.
Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic.
Int J Mol Sci
; 23(12)2022 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35743239
5.
Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents.
Molecules
; 27(8)2022 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458639
6.
Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum.
J Biol Chem
; 295(27): 9061-9068, 2020 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32430398
7.
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy.
J Biol Chem
; 295(19): 6263-6277, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32139506
8.
(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome.
J Biol Chem
; 295(10): 3247-3256, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996374
9.
Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment.
Biomedicines
; 12(3)2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38540254
10.
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation.
Cell Death Dis
; 15(5): 333, 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38740758
11.
Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a mouse model of Snyder-Robinson syndrome.
Dis Model Mech
; 17(6)2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38463005
12.
Snyder-Robinson syndrome presenting with learning disability, epilepsy, and osteoporosis: a novel SMS gene variant.
Rare
; 22024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38770537
13.
Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy.
bioRxiv
; 2023 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993333
14.
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome.
EMBO Mol Med
; 15(11): e17833, 2023 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37702369
15.
Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a novel mouse model of Snyder-Robinson Syndrome.
bioRxiv
; 2023 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711956
16.
Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
HGG Adv
; 4(3): 100206, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37333770
17.
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential.
bioRxiv
; 2023 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37034775
18.
Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy.
Med Sci (Basel)
; 10(3)2022 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35997336
19.
Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells.
JCI Insight
; 7(13)2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35801587
20.
DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.
Cancer Res
; 79(13): 3445-3454, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31088836