Pesquisa | Portal de Pesquisa da BVS

1.

Sensitizing protective tumor microenvironments to antibody-mediated therapy.

Pallasch, Christian P; Leskov, Ilya; Braun, Christian J; Vorholt, Daniela; Drake, Adam; Soto-Feliciano, Yadira M; Bent, Eric H; Schwamb, Janine; Iliopoulou, Bettina; Kutsch, Nadine; van Rooijen, Nico; Frenzel, Lukas P; Wendtner, Clemens M; Heukamp, Lukas; Kreuzer, Karl Anton; Hallek, Michael; Chen, Jianzhu; Hemann, Michael T.

Cell ; 156(3): 590-602, 2014 Jan 30.

Artigo em Inglês | MEDLINE | ID: mdl-24485462

2.

BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.

Flores-Romero, Hector; Hohorst, Lisa; John, Malina; Albert, Marie-Christine; King, Louise E; Beckmann, Laura; Szabo, Tamas; Hertlein, Vanessa; Luo, Xu; Villunger, Andreas; Frenzel, Lukas P; Kashkar, Hamid; Garcia-Saez, Ana J.

EMBO J ; 41(2): e108690, 2022 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-34931711

3.

Post-transplant-cyclophosphamide and short-term Everolimus as graft-versus-host-prophylaxis in patients with relapsed/refractory lymphoma and myeloma-Final results of the phase II OCTET-EVER trial.

Richardson, Tim; Scheid, Christof; Herling, Marco; Frenzel, Lukas P; Herling, Carmen; Aguilar, Marta Rebecca Cruz; Theurich, Sebastian; Hallek, Michael; Holtick, Udo.

Eur J Haematol ; 2024 Apr 14.

Artigo em Inglês | MEDLINE | ID: mdl-38616351

4.

MARCKS affects cell motility and response to BTK inhibitors in CLL.

Beckmann, Laura; Berg, Valeska; Dickhut, Clarissa; Sun, Clare; Merkel, Olaf; Bloehdorn, Johannes; Robrecht, Sandra; Seifert, Marc; da Palma Guerreiro, Alexandra; Claasen, Julia; Loroch, Stefan; Oliverio, Matteo; Underbayev, Chingiz; Vaughn, Lauren; Thomalla, Daniel; Hülsemann, Malte F; Tausch, Eugen; Fischer, Kirsten; Fink, Anna Maria; Eichhorst, Barbara; Sickmann, Albert; Wendtner, Clemens M; Stilgenbauer, Stephan; Hallek, Michael; Wiestner, Adrian; Zahedi, René P; Frenzel, Lukas P.

Blood ; 138(7): 544-556, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-33735912

5.

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P; Reinhardt, Hans Christian; Brüning, Jens C; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P; Wunderlich, F Thomas.

Blood ; 137(5): 646-660, 2021 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-33538798

6.

PI3K/BCL2: illusion or promise for RS?

Frenzel, Lukas P.

Blood ; 137(24): 3319-3321, 2021 06 17.

Artigo em Inglês | MEDLINE | ID: mdl-34137851

7.

Chimeric antigen receptor T cells targeting Fc µ receptor selectively eliminate CLL cells while sparing healthy B cells.

Faitschuk, Elena; Hombach, Andreas A; Frenzel, Lukas P; Wendtner, Clemens-Martin; Abken, Hinrich.

Blood ; 128(13): 1711-22, 2016 09 29.

Artigo em Inglês | MEDLINE | ID: mdl-27535994

8.

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Knittel, Gero; Liedgens, Paul; Korovkina, Darya; Seeger, Jens M; Al-Baldawi, Yussor; Al-Maarri, Mona; Fritz, Christian; Vlantis, Katerina; Bezhanova, Svetlana; Scheel, Andreas H; Wolz, Olaf-Oliver; Reimann, Maurice; Möller, Peter; López, Cristina; Schlesner, Matthias; Lohneis, Philipp; Weber, Alexander N R; Trümper, Lorenz; Staudt, Louis M; Ortmann, Monika; Pasparakis, Manolis; Siebert, Reiner; Schmitt, Clemens A; Klatt, Andreas R; Wunderlich, F Thomas; Schäfer, Stephan C; Persigehl, Thorsten; Montesinos-Rongen, Manuel; Odenthal, Margarete; Büttner, Reinhard; Frenzel, Lukas P; Kashkar, Hamid; Reinhardt, H Christian.

Blood ; 127(22): 2732-41, 2016 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-27048211

9.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

Berg, Valeska; Rusch, Marion; Vartak, Nachiket; Jüngst, Christian; Schauss, Astrid; Waldmann, Herbert; Hedberg, Christian; Pallasch, Christian P; Bastiaens, Philippe I H; Hallek, Michael; Wendtner, Clemens-Martin; Frenzel, Lukas P.

Blood ; 125(19): 2948-57, 2015 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-25670628

10.

Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells.

Göckeritz, Elisa; Kerwien, Susan; Baumann, Michael; Wigger, Marion; Vondey, Verena; Neumann, Lars; Landwehr, Thomas; Wendtner, Clemens M; Klein, Christian; Liu, Ningshu; Hallek, Michael; Frenzel, Lukas P; Krause, Günter.

Int J Cancer ; 137(9): 2234-42, 2015 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-25912635

11.

CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation.

Holtick, Udo; Frenzel, Lukas P; Shimabukuro-Vornhagen, Alexander; Theurich, Sebastian; Claasen, Julia; Scheid, Christof; von Bergwelt-Baildon, Michael; Fröhlich, Holger; Wendtner, Clemens M; Chemnitz, Jens M.

Ann Hematol ; 94(1): 129-37, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25118994

12.

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides.

Schwamb, Janine; Feldhaus, Valeska; Baumann, Michael; Patz, Michaela; Brodesser, Susanne; Brinker, Reinhild; Claasen, Julia; Pallasch, Christian P; Hallek, Michael; Wendtner, Clemens-Martin; Frenzel, Lukas P.

Blood ; 120(19): 3978-85, 2012 Nov 08.

Artigo em Inglês | MEDLINE | ID: mdl-22927247

13.

Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia (Comment to Tausch et al.).

Weiss, Jonathan; Peifer, Martin; Herling, Carmen D; Frenzel, Lukas P; Hallek, Michael.

Haematologica ; 104(11): e540, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31666345

14.

Venetoclax plus rituximab or obinutuzumab after allogeneic hematopoietic stem cell transplantation in chronic lymphocytic leukemia.

Al-Sawaf, Othman; Herling, Carmen Diana; Holtick, Udo; Scheid, Christoph; Cramer, Paula; Sasse, Stephanie; von Tresckow, Bastian; Tuchscherer, Armin; Fischer, Kirsten; Eichhorst, Barbara; Hallek, Michael; Frenzel, Lukas P.

Haematologica ; 104(5): e224-e226, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30792201

15.

Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia.

Al-Sawaf, Othman; Zhang, Can; Jin, Hyun Yong; Robrecht, Sandra; Choi, Yoonha; Balasubramanian, Sandhya; Kotak, Alex; Chang, Yi Meng; Fink, Anna Maria; Tausch, Eugen; Schneider, Christof; Ritgen, Matthias; Kreuzer, Karl-Anton; Chyla, Brenda; Paulson, Joseph N; Pallasch, Christian P; Frenzel, Lukas P; Peifer, Martin; Eichhorst, Barbara; Stilgenbauer, Stephan; Jiang, Yanwen; Hallek, Michael; Fischer, Kirsten.

Nat Commun ; 14(1): 2147, 2023 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-37072421

16.

Comparison of the effects of two kinase inhibitors, sorafenib and dasatinib, on chronic lymphocytic leukemia cells.

Kuckertz, Mirjam; Patz, Michaela; Veldurthy, Aditya; Gehrke, Iris; Claasen, Julia; Frenzel, Lukas P; Wendtner, Clemens-Martin; Hallek, Michael; Krause, Günter.

Onkologie ; 35(7-8): 420-6, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22846973

17.

Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus.

Frenzel, Lukas P; Claus, Rainer; Plume, Nadine; Schwamb, Janine; Konermann, Carolin; Pallasch, Christian P; Claasen, Julia; Brinker, Reinhild; Wollnik, Bernd; Plass, Christoph; Wendtner, Clemens-Martin.

Int J Cancer ; 128(10): 2495-500, 2011 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-20669229

18.

Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells.

Patz, Michaela; Isaeva, Polina; Forcob, Nche; Müller, Bianka; Frenzel, Lukas P; Wendtner, Clemens-Martin; Klein, Christian; Umana, Pablo; Hallek, Michael; Krause, Günter.

Br J Haematol ; 152(3): 295-306, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21155758

19.

Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis.

Frenzel, Lukas P; Patz, Michaela; Pallasch, Christian P; Brinker, Reinhild; Claasen, Julia; Schulz, Alexandra; Hallek, Michael; Kashkar, Hamid; Wendtner, Clemens-Martin.

Br J Haematol ; 152(2): 191-200, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21091905

20.

miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia.

Pallasch, Christian Philipp; Patz, Michaela; Park, Yoon Jung; Hagist, Susanne; Eggle, Daniela; Claus, Rainer; Debey-Pascher, Svenja; Schulz, Alexandra; Frenzel, Lukas P; Claasen, Julia; Kutsch, Nadine; Krause, Günter; Mayr, Christine; Rosenwald, Andreas; Plass, Christoph; Schultze, Joachim L; Hallek, Michael; Wendtner, Clemens-Martin.

Blood ; 114(15): 3255-64, 2009 Oct 08.

Artigo em Inglês | MEDLINE | ID: mdl-19692702

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