Real-World Prevalence of PD-L1 Expression Among Tumor Samples From Patients With Non-Small-Cell Lung Cancer.

INTRODUCTION: We analyzed the prevalence of non-small-cell lung cancer (NSCLC) with a programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) of ≥ 50% and compared the results with the existing data from clinical trials and databases from other countries. MATERIALS AND METHODS: The Latin American Cooperative Oncology Group and Grupo Brasileiro de Oncologia Torácica performed a retrospective, cross-sectional study from August 2017 to April 2018. PD-L1 expression was collected from pathology reports from 5 laboratories in Brazil. All tests were sponsored by the pharmaceutical industry on request from the treating medical oncologist. PD-L1 expression was assessed by immunohistochemistry. The variables were summarized as absolute and relative frequencies or the median and interquartile range. Pearson's χ2 test was used to compare the TPS categories stratified by sex, age, and histologic type. All analyses were performed with SAS, version 9.4, and were deemed statistically significant at P < .05. RESULTS: A total of 1512 patients were included in the present study. Their median age was 66 years. Most patients were men (56.02%), and the most common histologic type was adenocarcinoma (58.04%); 109 tumors (11.31%) had EGFR mutations and 34 (3.64%) had ALK gene rearrangements. Overall, 56.54% had a PD-L1 TPS < 1%, 25.63% a TPS of 1% to 49%, and 17.83% a TPS of ≥ 50%. The factors associated with PD-L1 expression were histologic type (with adenocarcinoma samples having a greater proportion of TPS < 1%) and the laboratory that performed the test. CONCLUSION: The prevalence of high PD-L1 expression among the Brazilian NSCLC samples was lower than previously described in other countries, which could affect the number of patients who might be candidates for immunotherapy alone.

Beckwith-Wiedemann syndrome and bilateral adrenal pheochromocytoma: sonography and MRI findings.

Beckwith-Wiedemann syndrome is characterized by a group of clinical abnormalities, the most frequent of which are omphalocele, macroglossia, gigantism, neonatal hypoglycemia and umbilical hernia. The association of this syndrome with malignant tumors is well documented. We report a child with this syndrome associated with bilateral adrenal pheochromocytoma.

Linfomas malt do cólon: relato de dois casos / Malt lymphomas of the colon: two cases report

The authors report two cases of MALT (Mucosa Associated Lymphoid Tissue) lymphoma of the colon, describing their peculiarities related to diagnosis, treatment and imunopathology. Both had no signs of systemic disease and were submitted to colectomy. Follow-up was uneventful . It's emphasized about raising the possibility of a MALT neoplasm whenever investigating a colonic tumor and the value of imunocitochemistry in the correct diagnosis of these lesions. We also discuss about the pathogens of this lesion.

Tumor de pequenas células redondas desmoplásico intra-abdominal: relato de caso / Intraabdominal desmoplastic small round cell tumor: case report

Os autores relatam um caso de tumor de pequenas células redondas desmoplásico intra-abdominal acometendo paciente do sexo masculino, de 21 anos de idade, atendido com quadro de dor abdominal, trombose do membro inferior direito e perda da função renal, de causa obstrutiva. A investigação demonstrou volumosa lesão abdominopélvica, sólida, bocelada, com áreas císticas internas, situada posteriormente à bexiga, causando obstrução ureteral, compressão da veia ilíaca direita e oclusão parcial do reto, além de acometimento de linfonodos intra e retroperitoneais. São descritos os achados cirúrgicos, de ultra-sonografia, tomografia computadorizada e ressonância magnética, bem como aqueles do estudo macroscópico, microscopia e imuno-histoquímica.

Análise da associação entre Papiloma Vírus Humano (HPV) e Neoplasia Intra-epitelial cervical / Analysis of the association of Human Papilloma Virus (HPV) and Cervical Intraepithelial Neoplasia

O objetivo deste estudo é analisar a incidência de alterações neoplásicas intra-epiteliais cervicais malignas e pré-malignas em relação à idade das pacientes e à infecção por HPV. Este trabalho constitui um estudo retrospectivo de casos de mulheres entre 15 e 89 anos de idade. São 467 casos com histologia confirmada em NIC I, II, III ou carcinoma invasor. Em 42,8 por cento dos acasos apresentaram alterações coilocíticas e nucleares compatíveis a infecção por HPV. A alta associação entre HPV e alterações morfológicas celulares é um forte indício de que este seja o principal responsável pelo surgimento e progressão das lesões neoplásicas intra-epiteliais cervicais

Neoplasia intra-epitelial cervical e o papiloma vírus humano / Intraepithelial neoplasy and human papiloma virus

O objetivo deste estudo é analisar a incidência de alteraçöes neoplásicas intra-epiteliais cervicais malignas e pré-malignas em relaçäo à idade das pacientes e à infecçäo por HPV. Foram estudados, retrospectivamente, 246 casos de pacientes do sexo feminino, com idade entre 15 e 85 anos, com histologia confirmada em NIC I, II, III, carcinoma in situ ou carcinoma invasor. Desses, 46,74 por cento apresentaram alteraçöes coilocíticas compatíveis com HPV positivo. Alta associaçäo entre HPV e alteraçöes morfológicas celulares é um forte indício de que este seja o principal respons