[Clinical efficacy of the biospecific hemosorbent "Liposorb"].

The aim of the present work was to evaluate clinical efficacy of the biospecific hemosorbent "Liposorb". The main component of "Liposorb" is polyacrylamide gel containing an immobilized affine ligand (antibiotic polymyxin E-colistyne). 40 patients with abdominal sepsis and peritonitis of different genesis underwent a total of 52 seances of vein-venous extracorporeal hemoperfusion of hemosorbent "Liposorb". Endotoxin level (lipopolysaccharide - LPS) was measured by the turbodimetric method. Blood perfusion through a "Liposorb" column at 50-70 ml/min during 90 minutes permitted to reach stabilization of parameters of systemic hemodynamics. All the patients showed positive dynamics of general well-being, blood gas composition, clinical and biochemical blood analyses. The endotoxin (LPS) level of Gramm-negative flora significantly decreased. It is concluded that hemosorbtion using biospecific polymyxin-containing hemosorbent "Liposorb" effectively removes Gramm-negative endotoxin and leads to stabilization of hemodynamic in patients with Gramm-negative abdominal sepsis.

[Response of subcellular structures of the dog liver to hemosorption in different stages of extrahepatic cholestasis]. / Reaktsiia subkletochnykh struktur pecheni sobak na provedenie gemosorbtsii v razlichnye étapy ékstrapechenochnogo kholestaza.

It was established in experiments on dogs that the effect of hemosorption on the mitochondrial apparatus and the lysosomal system of the hepatic cells in extrahepatic cholestasis depends on the stage of the pathological process and the corresponding prehemosorption condition of the subcellular structures.

Childhood leukemia in Belarus before and after the Chernobyl accident: continued follow-up.

Earlier assessments led to the conclusion that due to the added radiation after the Chernobyl accident, childhood leukemia in Belarus was not recognisably increased in the years 1987-1994 compared to the years 1982-1986, i.e. the period before the accident. The present paper gives the data of the continued follow-up (1995-1998) which was conducted by the Institute of Haematology and Blood Transfusion, Minsk. In line with the earlier observations no increase has been identified. The incidence rates have been compared to the data of the newly established Belarussian Childhood Cancer Registry and a tentative explanation is given for apparent differences between the rates from our follow-up and the data reported earlier by the Belarussian Childhood Cancer Registry.