Detalhe da pesquisa
1.
Safety and pharmacokinetics of antifungal agent VT-1598 and its primary metabolite, VT-11134, in healthy adult subjects: phase 1, first-in-human, randomized, double-blind, placebo-controlled study of single-ascending oral doses of VT-1598.
Med Mycol
; 62(4)2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38569652
2.
Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31383660
3.
In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910896
4.
The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530603
5.
Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues.
Bioorg Med Chem Lett
; 29(2): 339-341, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30477891
6.
The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.
Antimicrob Agents Chemother
; 62(4)2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29437615
7.
The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29987152
8.
In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104280
9.
Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus.
J Antimicrob Chemother
; 73(2): 404-408, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29190379
10.
VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans.
J Antimicrob Chemother
; 73(1): 151-155, 2018 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29040636
11.
VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.
J Antimicrob Chemother
; 73(8): 2089-2094, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29788070
12.
Efficacy of the Investigational Antifungal VT-1161 in Treating Naturally Occurring Coccidioidomycosis in Dogs.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289027
13.
Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461309
14.
Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28652241
15.
The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28483956
16.
Activity of VT-1129 against Cryptococcus neoformans clinical isolates with high fluconazole MICs.
Med Mycol
; 55(4): 453-456, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27664991
17.
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.
Bioorg Med Chem Lett
; 27(15): 3243-3248, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28651982
18.
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
Antimicrob Agents Chemother
; 60(8): 4530-8, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161631
19.
The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii.
Antimicrob Agents Chemother
; 60(4): 2528-31, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787697
20.
VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Antimicrob Agents Chemother
; 59(12): 7815-7, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26369977