Detalhe da pesquisa
1.
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Cell
; 167(3): 843-857.e14, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27720451
2.
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.
Proc Natl Acad Sci U S A
; 115(10): 2461-2466, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29467286
3.
The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.
Am J Physiol Endocrinol Metab
; 316(3): E397-E409, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30620636
4.
Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.
Acc Chem Res
; 50(8): 1855-1865, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28771323
5.
Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases.
J Pept Sci
; 24(1)2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29322647
6.
Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.
J Org Chem
; 82(7): 3506-3512, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28319665
7.
Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.
J Pept Sci
; 23(6): 455-465, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28466571
8.
Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.
J Pept Sci
; 21(3): 223-30, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25665061
9.
A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Mol Metab
; 80: 101863, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38182007
10.
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
Bioorg Med Chem
; 26(10): 2873-2881, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29153547
11.
Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes.
Cell Rep Med
; 3(4): 100598, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35492248
12.
Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.
Nat Commun
; 13(1): 6700, 2022 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36335114
13.
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems.
Mol Metab
; 66: 101638, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36400403
14.
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Nat Chem Biol
; 5(10): 749-57, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19597507
15.
Functional association of the N-terminal residues with the central region in glucagon-related peptides.
J Pept Sci
; 17(10): 659-66, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21661079
16.
Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.
J Pept Sci
; 17(3): 218-25, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21308878
17.
A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor.
Mol Metab
; 53: 101316, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34400347
18.
Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists.
J Med Chem
; 64(8): 4697-4708, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33821647
19.
Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence.
J Med Chem
; 63(11): 6134-6143, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32406685
20.
Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice.
Peptides
; 120: 170116, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31348991