Detalhe da pesquisa
1.
ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.
J Biol Chem
; 299(8): 105065, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37468098
2.
The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis.
J Cell Sci
; 135(5)2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34821358
3.
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.
Diabetologia
; 66(4): 709-723, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459178
4.
GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.
Diabetologia
; 66(7): 1306-1321, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36995380
5.
Chemerin as an Inducer of ß Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes ß Cell Mass Expansion.
Int J Mol Sci
; 24(11)2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298086
6.
γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion.
J Biol Chem
; 295(16): 5419-5426, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32156704
7.
LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.
Biochem Biophys Res Commun
; 568: 158-166, 2021 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34217973
8.
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
Diabetologia
; 62(12): 2273-2286, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31624901
9.
Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells.
Diabetologia
; 59(9): 1855-9, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27421727
10.
Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet ß cell.
J Biol Chem
; 289(47): 32798-810, 2014 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25271154
11.
AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes.
Am J Physiol Heart Circ Physiol
; 307(8): H1120-33, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25128166
12.
Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation.
Genome Res
; 21(1): 95-105, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21088282
13.
3D evaluation of the extracellular matrix of hypoxic pancreatic islets using light sheet fluorescence microscopy.
Islets
; 16(1): 2298518, 2024 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38267218
14.
Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic ß cells.
Pflugers Arch
; 465(4): 543-54, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23149488
15.
Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic ß-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1.
Biochem J
; 441(3): 971-8, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22050124
16.
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice.
Proc Natl Acad Sci U S A
; 107(11): 5208-13, 2010 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20194741
17.
GLP-1 and GIP receptors signal through distinct ß-arrestin 2-dependent pathways to regulate pancreatic ß cell function.
Cell Rep
; 42(11): 113326, 2023 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37897727
18.
Glucose inhibits glucagon secretion by decreasing [Ca2+]c and by reducing the efficacy of Ca2+ on exocytosis via somatostatin-dependent and independent mechanisms.
Mol Metab
; 61: 101495, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35421610
19.
In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.
Front Cell Dev Biol
; 10: 967765, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36060810
20.
KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin.
Mol Metab
; 53: 101268, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34118477