Early identification of cancer-related malnutrition in patients with colorectal cancer before and after surgery: a literature review.

PURPOSE: The aim of this literature review is to provide a comprehensive overview of methods for early identification of cancer-related malnutrition and/or risk of malnutrition in patients with colorectal cancer. The focus is also on applicability and feasibility of the use of nutritional tools in oncology clinical practice. METHODS: The literature search was conducted from November to December 2020 in the health science databases by two independent persons. Inclusion criteria were English and German language and articles from 2010 to 2020. Data analysis was carried out through a structured procedure. The research questions guided the literature review. RESULTS: After removing duplicates and screening titles and abstracts, a total of 35 studies were identified as suitable publications and further analyzed. Eventually, nine original studies, with a total of 926 patients with colorectal cancer before or before and after surgery, addressed assessment measures for early identification of the risk or presence of malnutrition. The following types of nutritional assessment have been described: nutritional anthropometric measurements, laboratory chemistry diagnostics for malnutrition, and several validated nutritional screening and assessment tools. The nutritional tools demonstrate differences in terms of application and content. None of the reviewed studies was a randomized trial. There is little scientific evidence to underpin their specific application in identifying early cancer-related malnutrition in patients with colorectal cancer. CONCLUSION: The early assessment of nutritional status in this patient group seems to lack evidence-based standardization in oncology clinical practice. Different groups of health professionals are involved; however, studies do not describe standardized roles. Physical activity as part of nutritional screening is not yet included in the analyzed screening tools.

[Promoting physical activity in women during breast cancer therapy: A mixed methods evaluation of a nursing counselling intervention]. / Bewegungsförderung bei Frauen während der Brustkrebstherapie.

Promoting physical activity in women during breast cancer therapy: A mixed methods evaluation of a nursing counselling intervention Abstract. Background: Physical activity is associated with improved quality of life in women during breast cancer treatment. However, how physical activity behaviour of patients changes in the first months after the start of the treatment and what role nursing counselling can play has not yet been sufficiently investigated. Aim: To observe differences in physical activity behaviour in women with breast cancer at the time of the initiation of the therapy and six months later, and to explore patients' and health professionals' perspective on a nursing counselling intervention on physical activity. Methods: A mixed-methods evaluation was conducted. In the quantitative part, the physical activity behaviour was assessed at two time points (t0 and t1) with the SQUASH instrument (30-2Wendel-Vos, 2003). In the qualitative part, one focus group interview was conducted with patients and health professionals separately. The quantitative data were analyzed using descriptive and inductive statistics. The qualitative data were analyzed thematically. Results: The sample (N = 47) showed a slight, but not significant increase in the extent of physical activity comparing t1 with t0. A statistically significant increase in the amount of exercise between t0 and t1 was only found in the category "work" (p = 0,002). The central theme of the women was that they felt encouraged by the nursing counselling intervention to "do something for themselves". For the health professionals, in the context of counselling it was important that they themselves were convinced of the importance of physical activity. Conclusions: The integration of physical activity into everyday life is a challenge for women with breast cancer during therapy. A counselling intervention is perceived as supportive but could have a more lasting effect through a longer-term physical activity programme.

Employment trajectories of young women with breast cancer: an ongoing prospective cohort study in Italy and Switzerland.

PURPOSE: Despite extensive research on cancer and work-related outcomes, evidence from longitudinal cohort studies is limited, especially in young women with breast cancer (BC). We aimed to investigate employment trajectories in young BC survivors and to identify potential factors associated with changes in work activity. METHODS: The HOHO European prospective multicenter cohort study enrolled 300 young women (≤ 40 years) with newly diagnosed BC. Women completed surveys at baseline and every 6 months for 3 years, then yearly for up to 10 years to assess, among other variables, employment status, sociodemographic, medical, and treatment data. Symptoms were assessed by the Breast Cancer Prevention Trial symptom scales and single items from the Cancer Rehabilitation Evaluation System. Univariable and multivariable multinomial logistic regression analyses identified factors associated with changes in employment status. RESULTS: Among the 245 women included in this analysis, 85% were employed at the last individual post-baseline assessment (1 to 10 years). At 5 years, women had a 29.4% probability (95% CI: 23.6-35.5) of experiencing any reduction and a 14.9% probability (95% CI: 10.6-19.9) of experiencing any increase in work activities. Being enrolled in Switzerland (vs. Italy) and reporting more trouble in performing daily activities were significantly associated with work reduction. CONCLUSION: Our results suggest that most young BC survivors remain employed in the long-term. IMPLICATIONS FOR CANCER SURVIVORS: Regular evaluation of symptoms which may interfere with daily life and identification of financial discomfort is critical in providing timely and individually tailored interventions and in limiting unwanted reductions in work activities.

Preventive therapy for breast cancer: a consensus statement.

In March, 2010, a group of breast cancer experts met to develop a consensus statement on breast cancer prevention, with a focus on medical and therapeutic interventions. We present the conclusions in this Review. First we agreed that the term chemoprevention is inappropriate and suggested that the term preventive therapy better represents this feature of management. Two selective oestrogen-receptor modulators--tamoxifen and raloxifene--are so far the only medical options approved by the US Food and Drug Administration for preventive therapy. Of these tamoxifen has greater efficacy and can be used in premenopausal women, but raloxifene has fewer side-effects. Two newer drugs in this class, lasofoxifene and arzoxifene, also show efficacy and possibly a better overall risk-benefit profile, but need further assessment. Aromatase inhibitors might be more efficacious, and results of prevention trials are eagerly awaited. Newer agents, notably bisphosphonates and metformin, have shown promise in observational studies and need to be assessed in randomised prevention trials. Other agents, such as aspirin, other non-steroidal anti-inflammatory drugs, COX-2 inhibitors, retinoids, rexinoids, and dietary components have limited effects or are in the early phases of investigation. New contralateral tumours in women with breast cancer might be generally useful as a model for prevention, as has been seen for tamoxifen. If valid such a model would facilitate the design of simpler, cheaper, and better-focused trials for assessing new agents.

Supporting older adults with chemotherapy treatment: A mixed methods exploration of cancer caregivers' experiences and outcomes.

PURPOSE: Due to delivery of chemotherapy being mostly in ambulatory care settings, support of people with cancer relies heavily on caregivers (e.g. relatives). Whilst cancer caregiver research has been flourishing, there has been little focus on the specific experiences of caregivers of older people (>70yrs) with cancer, and little considerations of cultural influences on their experiences. This study explored caregiver experiences and outcomes in the geriatric oncology context in Switzerland. METHODS: Sequential mixed-methods design, comprising a) cross-sectional survey (n = 86/RR52%; age range 37-85) and b) interviews (n = 19) to explore experiences of caregivers of older people (mean age in yrs 74.6 (sd 4.3) with cancer, and factors related to caregivers' psychological morbidity and health related quality of life (HrQoL). RESULTS: Caregivers reported a median of three moderate/high unmet needs (range 0-41) and 44% reported clinically significant psychological morbidity. Demographics (caregiver age, gender, and marital status), caregiving tasks (physical, psycho-emotional, social and/or treatment related care), unmet needs and caregiver burden collectively explained between 20 and 57% of variance in caregiver psychological morbidity and HRQoL. Two main themes emerged from interviews: "Being a caregiver and doing caregiving" and "Living through the situation." These indicated that caregiver roles are multiple and fluid, and identified responsibilities not previously reported outside of palliative care settings, such as thinking about and planning for death and dying. CONCLUSIONS: Caregiving for an older person with cancer can have detrimental impacts on caregivers' wellbeing and quality of life. Consideration needs to be given to the particular needs of caregivers in geriatric oncology settings. Their support needs appear different to those of their counterparts caring for younger people with cancer, notably related to spiritual needs; this may in part relate to possible differences arising from caregivers themselves being older.

Breast cancer patients on endocrine therapy reveal more symptoms when self-reporting than in pivotal trials: an outcome research study.

OBJECTIVES: The purpose of this investigation was firstly to assess the overall frequency of subjectively experienced symptoms self-reported by patients receiving endocrine therapy and secondly to compare these symptoms with side effects assessed by clinicians in pivotal trials. METHODS: Unselected patients with early and advanced breast cancer receiving endocrine therapy were approached consecutively during a routine outpatient visit. They received a questionnaire called Checklist for Patients with Endocrine Therapy (C-PET), a validated self-assessment tool to determine prespecified symptoms associated with endocrine therapy. Data on toxicity were also obtained from previously published trials. RESULTS: 405 patients were approached and 373 agreed to participate in this study. Some symptoms were significantly more often recorded by the women in the adjuvant setting completing the C-PET than by physicians' reports in pivotal trials: hot flushes/sweats (C-PET 70%, ATAC 40% and BIG1-98 38%), low energy (C-PET 45%, ATAC 15% and BIG1-98 9%), fluid retention (C-PET 22% and BIG1-98 7%) and vaginal dryness (C-PET 30% and BIG1-98 3%). Similar differences were observed in the metastatic and adjuvant setting. CONCLUSIONS: A simple tool like the C-PET questionnaire is able to reflect the treatment burden of endocrine therapies and may be helpful to improve communication between patients and care providers. Some symptoms were significantly more often reported by the women in the C-PET than by physicians in pivotal trials.

[The assessment of nursing care needs in cancer patients]. / Pflegebedarfserhebung auf onkologischen Abteilungen in einem deutschen Universitätsklinikum.

In order to explore the status quo of the assessment of nursing care needs in newly admitted inpatients on oncology wards a survey in a German university hospital was carried out. Research questions included: Do the nurses collect data regarding nursing care needs of admitted cancer patients? When are the data collected? What data are collected? What is documented, when is it documented, and is the patient involved in the documentation? What, if any, factors on the part of nurses have an impact on the way in which these data are collected? Two methods were used to collect research data: nursing documents of hospitalised cancer patients were analysed (n = 68), followed by an interview with the nurses (n = 81). Beforehand, an instrument was developed and tested for both investigative methods. The main result was: the nurses' perception of the needs' assessment was incongruent with data in the patients' documentation files. The study showed that nurses consider their documentation of nursing care needs to be more comprehensive with regard to the time and content/areas of documentation than it actually is. With regard to the psychological, social, and spiritual care needs, for example, this means: in the nurses' own opinion, they had taken into account these needs far more strongly than they actually had. According to the analysis of the care documents, patients were involved in the documentation in 15% of the cases. According to the nurses, general communication skills, the use of assessment instruments, and the standardisation of the documentation need to be improved. The review of international literature confirms the deficiency recorded by this survey. The oncology patients' perspective should be included more strongly in the assessment of nursing care needs. In this way, individual nursing care needs are assumed to be understood more appropriately. Self-assessment instruments could be a suitable resource in this context. The instruments have to be introduced by education, and their validity, reliability, practical relevancy, and applicability need to be checked continuously.

Recommendations for symptom management in women with vulvar neoplasms after surgical treatment: An evidence-based guideline.

PURPOSE: To develop an evidence-based guideline for nurses and other health care professionals involved in pre- and postsurgical care of women with vulvar cancer (VC) or vulvar intraepithelial neoplasia (VIN). METHODS: This evidence-based guideline was developed according to six domains of the methodological framework AGREE II. Literature research with focus on cancer care, symptom management and self-management/counselling was conducted from April to August 2013 in the databases CINAHL, Cochrane Library, PsycINFO, PubMed as well as in 14 international guideline databases. Interdisciplinary experts (n = 14) were involved in the development of the guideline from December 2013 to January 2014. This guideline is currently tested in the WOMAN-PRO II RCT (Clinical Trial No: NCT01986725). RESULTS: For the definition of recommendations, five guidelines, one meta-analysis, two systematic reviews and two randomized controlled trials were included. In total, 24 recommendations were formulated to answer 22 clinical questions based on patients' perspective and experts' opinion. Evidence ranged from 3.5 to 5 (3.5 = weak evidence and/or clinical relevance, 5 = best evidence and/or clinical relevance). The recommendations were subsumed under different themes regarding physical, psychological and psychosocial aspects. CONCLUSIONS: The clinical practice guideline developed in this study firstly provides recommendations for symptom management issues focusing on self-management interventions for women with VC or VIN. As an interdisciplinary guideline it should be used in addition to the existing medical guideline in the German speaking context.

Quality and efficacy of educational materials on cancer-related fatigue: views of patients from two European countries.

Cancer-related fatigue is a symptom with great implications for the quality of life of those that experience it. It is regarded as one of the most distressing symptoms that people with cancer develop. Its aetiology is complex, and although the mechanisms underlying fatigue have not been fully clarified it is evident that it is exacerbated by treatments intended to cure or palliate the disease. Patients at risk of cancer-related fatigue need access to information that will enable them to manage it effectively. There are a growing number of materials available to patients in different European countries on this topic, but it is unclear how useful patients find these. This study was undertaken to explore this through conducting focus groups with patients in the United Kingdom and Switzerland. One focus group was conducted in each country. Findings from these determined that individuals voiced common concerns: fatigue had not been addressed in the clinical setting - individuals surmised why this occurred; participants had not accessed materials on cancer-related fatigue previously; they made recommendations for future resources for patients. However, what was evident was that unless patients can access materials on this topic, their quality becomes purely an academic issue.

[Breast cancer prevention behaviour: a perspective of women from three language regions of Switzerland]. / Das Brustkrebs-Präventionsverhalten in der Schweiz: aus der Perspektive von Frauen aus drei Sprachregionen der Schweiz.

UNLABELLED: Swiss women show, together with women from the Netherlands, France, Belgium, Sweden, Finland, England and Germany, a very high incidence of breast cancer in Europe. Whilst the evidence for primary cancer prevention is slowly growing, its strategies can not yet be implemented in clinical prevention programmes. Therefore, secondary prevention, early detection of cancer, remains the main focus for reducing breast cancer mortality. This is especially true because of the proven relationship between mortality and size of the primary tumour as well as the status of the axilla. Despite these facts, in contrast to the French part of Switzerland, breast cancer screening has not yet been implemented in the German and Italian part of Switzerland. METHODS: It was the aim of this study to identify prevention measures used by women living in the German-, Italian- and French-speaking part of Switzerland and to explore their attitude towards breast cancer prevention measures. It was asked what these women knew about breast cancer prevention, what type of secondary prevention they used and who motivated them to do so. The investigation included 1721 women from three language regions of Switzerland. Data were collected with a postal survey questionnaire. Descriptive, uni- and multivariate methods were used for data analysis. RESULTS: The response rate was 34%. Statistically significant differences in breast self-examination were observed between the three regions (p = < 0.001) and defined age-groups (p = < or = 0.001). In all three regions of the country, 90% of women age 50-59 had mammograms, whereas in comparison to the other regions, fewer women from the German part of Switzerland, aged 60-69, had undergone mammography screening. Significant differences in mammography screening again were observed between language regions (p = < or = 0.001) and age-groups (p = < or = 0.001). Eighty-four percent of women were motivated by the gynaecologist to have a mammography, 11% by the family doctor and 10% of the women decided by themselves. More than half of this female Swiss study population wished to see a health policy providing mammography-screening in Switzerland and about one third wished to be more informed about the intervention. An increased need for information and education about prevention and early detection was observed in individuals who had a relative with cancer. CONCLUSIONS: The majority of women in this study wished to see a health policy in Switzerland which includes a mammography screening programme. Opportunistic mammography screening, lacking systematic quality control and data collection for epidemiological purposes, was widely used in the Italian and in the German speaking region. Data show that there is a need for public and professional information and education about prevention and early detection of breast cancer to prevent misconceptions regarding the effect of breast self-examination and mammography-screening. Womens' organisations and nurses may be in a good position to take up a leading role in breast cancer prevention.

[Attitude of cancer patients to fatigue: patient attitude in Switzerland and England]. / Was Krebskranke von den Informationen über Fatigue halten: eine Beurteilung durch Patienten in der Schweiz und in England.

UNLABELLED: In the course of a cancer trajectory, many patients suffer from distressing fatigue. In past years, research has shown that care givers tend to underestimate or even to ignore this frequent phenomenon. Despite increasing knowledge, fatigue seems to remain an orphan topic in symptom management. AIM: A qualitative research strategy was used to explore the perception of cancer patients regarding the awareness of fatigue in professionals and the way they deal with it. Patients also evaluated the usefulness of some currently available information material about fatigue. METHODS: The expert-opinion of cancer patients in Switzerland and England was analysed. Convenient sampling guided the selection process of seven patients in each country. A tape-recorded focus-group interview served as method to collect and transcribe data. Data were analysed according to the framework analyses by Richie & Spencer. RESULTS: Results were very similar in both countries. Patients stated a great need for more information regarding fatigue. They feel that care givers are not sufficiently aware of it and that a specific support is not part of current standard practice. The information material was well received and generally judged as very good and helpful. CONCLUSIONS: Communication barriers in professionals as well as in patients continue to exist. Patients wish to be better informed by care givers. The available information material serves well to support this information as they provide words for the unmentioned phenomenon. Far more professional fatigue education is needed to raise care givers' awareness.

Chemotherapy-induced nausea and vomiting in routine practice: a European perspective.

GOALS OF WORK: The aim of this study was to evaluate the occurrence of chemotherapy-induced nausea and vomiting (CINV) and its effect on patients' ability to carry out daily life activities following moderately to highly emetogenic, first-cycle chemotherapy in routine practice in cancer centers of four different European countries. PATIENTS AND METHODS: This was a prospective, cross-sectional, nonrandomized, self-assessment study in 249 patients enrolled from cancer centers in Spain, Austria, Germany, and Switzerland. The study population consisted of 78% women, with a mean age of 54. Breast, lung, and ovarian cancers made up 75% of all cancers in the study. Patients received a mean of 2.0 chemotherapy agents and 2.5 antiemetic drugs. MAIN RESULTS: A total of 450 emetic episodes experienced by 243 patients was recorded over 5 days following chemotherapy, with an average of 1.8 episodes per patient (range: 0-28). A higher percentage of patients (38%) suffered from delayed compared to acute emesis (13%). Between 42% and 52% of all patients suffered from nausea (visual analogue scale > or = 5 mm) on any one day, peaking at day 3. Using the Functional Living Index for Emesis (FLIE) questionnaire, 75% of patients with nausea and 50% with vomiting reported a negative impact of these conditions on performance of daily living. CONCLUSIONS: CINV remains a significant problem in routine practice, particularly in the delayed phase posttreatment. Overall, CINV had a negative impact on patients' daily life.