Detalhe da pesquisa
1.
Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model.
Antimicrob Agents Chemother
; 67(6): e0157422, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37133382
2.
Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection.
J Infect Dis
; 225(6): 1062-1069, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32479608
3.
New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations.
Antimicrob Agents Chemother
; 66(11): e0055622, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36197116
4.
Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.
Antimicrob Agents Chemother
; 66(7): e0011422, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727057
5.
Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.
Antimicrob Agents Chemother
; 65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33526486
6.
Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria.
J Antimicrob Chemother
; 76(9): 2325-2334, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34179977
7.
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
Clin Infect Dis
; 71(10): e657-e664, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32239164
8.
Characterising the blood-stage antimalarial activity of pyronaridine in healthy volunteers experimentally infected with Plasmodium falciparum.
Int J Antimicrob Agents
; 64(1): 107196, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38734217
9.
A pharmacokinetic-pharmacodynamic model for chemoprotective agents against malaria.
CPT Pharmacometrics Syst Pharmacol
; 12(1): 50-61, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36412499
10.
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.
Pharmaceuticals (Basel)
; 16(2)2023 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37009844
11.
Development and application of a PBPK modeling strategy to support antimalarial drug development.
CPT Pharmacometrics Syst Pharmacol
; 12(9): 1335-1346, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37587640
12.
Efficient simulation of clinical target response surfaces.
CPT Pharmacometrics Syst Pharmacol
; 11(4): 512-523, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35199969
13.
Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs.
Am J Trop Med Hyg
; 107(4): 804-814, 2022 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037868
14.
Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development.
Clin Transl Sci
; 14(2): 712-719, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33326705
15.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290058
16.
Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study.
Clin Pharmacol Ther
; 108(5): 1055-1066, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32415986
17.
Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development.
Sci Rep
; 10(1): 4410, 2020 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32157151
18.
Setting Our Sights on Infectious Diseases.
ACS Infect Dis
; 6(1): 3-13, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31808676
19.
Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
J Med Chem
; 62(23): 10816-10832, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31729873
20.
Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.
Lancet Infect Dis
; 18(8): 874-883, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29909069