Detalhe da pesquisa
1.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
2.
Facile Formation of Redox-Active Totally Organic Nanoparticles in Water by In Situ Reduction of Organic Precursors Stabilized through Aromatic-Aromatic Interactions by Aromatic Polyelectrolytes.
Macromol Rapid Commun
; 37(21): 1729-1734, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27616076
3.
Analysis of the Physicochemical Properties of Anti-Schistosomal Compounds to Identify Next-Generation Leads.
ACS Med Chem Lett
; 15(5): 626-630, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746890
4.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
5.
Phenolic Profile, Antioxidant and Enzyme Inhibition Properties of the Chilean Endemic Plant Ovidia pillopillo (Gay) Meissner (Thymelaeaceae).
Metabolites
; 12(2)2022 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35208165
6.
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
J Med Chem
; 61(13): 5692-5703, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889526
7.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
8.
A metal-complex-tolerant CuAAC 'click' protocol exemplified through the preparation of homo- and mixed-metal-coordinated [2]rotaxanes.
Chem Commun (Camb)
; (41): 4218-20, 2007 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18217585
9.
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
J Med Chem
; 59(21): 9890-9905, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748596
10.
Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.
J Med Chem
; 58(18): 7572-9, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26322748
11.
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
J Med Chem
; 58(21): 8713-22, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502160
12.
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.
J Med Chem
; 57(21): 8839-48, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25313449
13.
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
J Med Chem
; 57(6): 2789-98, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24568587
14.
2,4-Diaminothienopyrimidines as orally active antimalarial agents.
J Med Chem
; 57(3): 1014-22, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446664
15.
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
J Med Chem
; 56(21): 8860-71, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24099149
16.
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
J Med Chem
; 55(7): 3479-87, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390538
17.
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
J Med Chem
; 55(24): 11022-30, 2012 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23189922
18.
An allosterically regulated molecular shuttle.
Angew Chem Int Ed Engl
; 45(9): 1385-90, 2006 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16444780
19.
Novel orally active antimalarial thiazoles.
J Med Chem
; 54(21): 7713-9, 2011 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21966980
20.
Complexation-induced translational isomerism: shuttling through stepwise competitive binding.
Angew Chem Int Ed Engl
; 45(1): 77-83, 2005 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16311993