[Frequency of adverse reactions after influenza vaccination in health care personnel of a university hospital in Spain]. / Frecuencia de reacciones adversas de la vacuna antigripal en personal sanitario de un hospital universitario en España.

INTRODUCTION: One of the reported arguments to health-care personnel receiving influenza vaccination is fear of Adverse Reactions (AR). The objective of this study was to investigate the frequency and characteristics of AR associated with the influenza vaccine. METHODS: Cohort study; 2587 health-care workers vaccinated against influenza during the seasons 2006-2007, 2007-2008 and 2008-2009 were included. They were asked about any AR seven days after the vaccination. RESULTS: A total of 1893 health-care workers were evaluated (73.2%). An AR was reported by 30.3%. There were no serious AR reported. CONCLUSION: The fear of the severity of AR does not seem to be justifiable as a reason for refusing the flu vaccine.

Timing of DVT prophylaxis and risk of postoperative knee prosthesis infection.

This multicenter prospective study was performed to determine risk factors for knee prosthesis infection and the effect of timing doses of prophylactic low-molecular-weight heparins (LMWH) related to time of surgery on the risk of knee prosthesis infection. A total of 5496 consecutive patients who underwent total knee arthroplasty from 2005 to 2006 in 13 orthopedic centers were prospectively followed up for 6 months, and the incidence of knee prosthesis infection was recorded. A case control study was nested in the cohort. Case patients were matched to uninfected (control) patients, and the timing of perioperative LMWH was recorded as the main risk factor. Fifty patients developed postoperative knee prosthesis infection during the follow-up period, yielding an incidence of prosthesis infection of 0.91% (95% CI, 0.68%-1.20%). Forty-four patients were matched to 106 controls. Case patients received the first LMWH dose ±12 hours from the start of surgery more frequently than their control counterparts (odds ratio, 1.5; 95% CI, 0.73-3.0). After adjusting by main risk factors, no statistical association was found between close perioperative timing of LMWH and risk of prosthesis infection. Diabetes mellitus (adjusted odds ratio, 3.2; 95% CI, 1.2-8.8) and wound hematoma (adjusted odds ratio, 4.2; 95% CI, 1.1-16.5) were found to be independent risk factors for prosthesis infection.

Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation.

BACKGROUND: Maternal hypothyroxinemia, due to gestational iodine deficiency, causes neurological dysfunctions in the progeny. Our aim was to determine the effects of delayed iodine supplementation (200 microg KI per day) to mildly hypothyroxinemic pregnant women at the beginning of gestation (i.e., having circulating free thyroxine [FT(4)] within the 0th-10th percentile interval and normal thyrotropin [TSH]) on the neurobehavioral development of their children. METHODS: Using the Brunet-Lézine scale, we evaluated the neurocognitive performance at 18 months of age in three groups of children. Group 1 included children of women with FT(4) above the 20th percentile at 4-6 gestational weeks and at full-term. Group 2 included children of mildly hypothyroxinemic women diagnosed during the first 12-14 gestational weeks and with FT(4) above the 20th percentile at full-term. Group 3 included children born to mildly hypothyroxinemic women at full-term, without iodine supplementation during gestation. Women of all groups were iodine supplemented from the day of enrollment until the end of lactation. RESULTS: Before iodine supplementation, 33.0% of the women (114 out of 345) were hypothyroxinemic, with FT(4) below normal in 28 of them (8.1%). None were found to be hypothyroxinemic at full-term after supplementation. The mean (+/-SD) developmental quotient of children was 101.8 +/- 9.7 in group 1 (n = 13) vs. 87.5 +/- 8.9 in group 3 (n = 19; p < 0.001) and 92.2 +/- 5.4 in group 2 (n = 12; p < 0.05). The difference between groups 2 and 3 was not statistically significant. Delayed neurobehavioral performance was observed in 36.8% and 25.0% of children in groups 3 and 2, respectively, compared with no children in group 1. Differences (p < 0.001) were found on gross and fine motor coordination and socialization quotients. No statistically significant differences were found on language quotients. CONCLUSIONS: A delay of 6-10 weeks in iodine supplementation of hypothyroxinemic mothers at the beginning of gestation increases the risk of neurodevelopmental delay in the progeny. Public health programs should address the growing problem of iodine deficiency among women of gestational age in developing and industrialized nations.

[Compliance with hand hygiene guidelines and determinants of compliance]. / Grado de cumplimiento y determinantes de las recomendaciones sobre la higiene de manos.

INTRODUCTION: A basic indicator for assessing a program aimed at improving hand hygiene (HH) is the degree of compliance with the recommendations established for this purpose. The aim of this study is to investigate this indicator and related determinant factors in a general hospital. METHODS: We performed 166 observation periods of one hour's duration, distributed over three work shifts and covering all the hospitalization units; 3957 HH opportunities were recorded. Variables associated with the observation period, the professionals involved and the medical activity taking place were also recorded. The Chi-square test, and calculation of the raw OR and the adjusted OR with a logistic regression model were used to study associations between the variables studied and failure to perform HH. RESULTS: The overall frequency of HH activity was 30%, ranging from 8.9% to 60.5% depending on the professional tasks involved. The most important independent risk factors for failure to perform HH were the following: no availability of alcohol in a pocket size bottle (OR: 2.3 [1.7-3.3]); medical activities carried out in the surgical unit (OR: 2.6 [2.0-3.3]); activities taking place before entering into contact with patients (OR: 3.2 [2.4-4.2]); and use of gloves during the activity (OR: 2.2 [1.6-3.2]). CONCLUSION: The frequency of HH is low, but there are several potentially modifiable factors involved, which could improve with interventions. One example might be better education of hospital personnel on the importance of HH.

[Influenza vaccination in healthcare workers. Why are some vaccinated whereas others are not]. / Vacunación de gripe en trabajadores sanitarios. Por qué se vacunan y por qué no se vacunan.

BACKGROUND AND OBJECTIVE: Influenza vaccination is indicated in health professionals. Nevertheless, vaccination coverage in healthcare workers tends to be low. This paper determines the reasons why some workers are vaccinated whereas others are not and investigates what type of intervention can modify the latter attitude. METHOD: This was a cross-sectional descriptive study using a questionnaire survey. SETTING: workers at Hospital General Universitario de Alicante (Alicante, Spain). Absolute frequencies and relative frequencies expressed in percentages were calculated for each of the variables studied. Results were analyzed considering the professional categories of the persons involved and the departments where they worked. RESULTS: The reasons for influenza vaccination stated by hospital workers were to protect their health (65.6%), the belief that vaccination is beneficial (45.7%), and to avoid transmitting influenza to their patients (42.5%), and to their own families (39.8%). The main reasons for not undergoing vaccination were to avoid medication (17.9%), confidence in their own defenses (17%), or fear of the secondary effects of the vaccine (16.8%). CONCLUSION: The main reason given by hospital personnel for undergoing vaccination was to protect their own health and that of their family and patients. The reasons most frequently given for not undergoing vaccination were based on possible side effects of the vaccine, the conviction of not being part of a high-risk group, and doubts about the effectiveness of the vaccine as a protective agent. Many of the reasons given for not undergoing vaccination were based on erroneous beliefs and should be taken into account when designing strategies to increase influenza vaccination coverage among health personnel.