Detalhe da pesquisa
1.
Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells.
J Biol Chem
; 298(1): 101477, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896393
2.
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Antimicrob Agents Chemother
; 66(4): e0210921, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266827
3.
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).
Int J Mol Sci
; 22(9)2021 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33922601
4.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
5.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Bioorg Med Chem Lett
; 22(21): 6656-60, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010269
6.
Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.
ACS Med Chem Lett
; 5(12): 1278-1283, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25530830
7.
Discovery of ML314, a Brain Penetrant Non-Peptidic ß-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
ACS Med Chem Lett
; 4(9): 846-851, 2013 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24611085
8.
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.
ACS Chem Neurosci
; 3(3): 221-236, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22737280
9.
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
J Med Chem
; 55(16): 7262-72, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22813531