Detalhe da pesquisa
1.
Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors.
Bioorg Med Chem Lett
; 28(3): 400-404, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29277458
2.
Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer.
Bioorg Med Chem
; 26(3): 590-602, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29289448
3.
A stress response pathway regulates DNA damage through ß2-adrenoreceptors and ß-arrestin-1.
Nature
; 477(7364): 349-53, 2011 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21857681
4.
Amino acid derived quinazolines as Rock/PKA inhibitors.
Bioorg Med Chem Lett
; 23(6): 1592-9, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23416002
5.
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
J Med Chem
; 66(11): 7162-7178, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37204207
6.
Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II).
Bioorg Med Chem Lett
; 21(23): 7113-8, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22018789
7.
Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
Bioorg Med Chem Lett
; 21(23): 7107-12, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22004718
8.
Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.
Bioorg Med Chem Lett
; 21(6): 1844-8, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21349713
9.
ßarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Cell Death Differ
; 27(4): 1200-1213, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31506606
10.
Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase.
Mol Cancer Ther
; 19(8): 1623-1635, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32430484
11.
Protease activation during in vivo pancreatitis is dependent on calcineurin activation.
Am J Physiol Gastrointest Liver Physiol
; 297(5): G967-73, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20501444
12.
Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
Bioorg Med Chem Lett
; 19(23): 6686-90, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19837589
13.
Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex.
Curr Biol
; 12(1): 79-84, 2002 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11790308
14.
Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions.
Mol Biol Cell
; 13(2): 579-92, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11854414
15.
In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.
ACS Med Chem Lett
; 8(12): 1258-1263, 2017 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29259744
16.
Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors.
J Biomol Screen
; 20(7): 913-20, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851035
17.
Therapeutic targeting of casein kinase 1δ in breast cancer.
Sci Transl Med
; 7(318): 318ra202, 2015 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26676609
18.
Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.
J Med Chem
; 56(9): 3568-81, 2013 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23570561
19.
Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats.
ACS Med Chem Lett
; 1(4): 175-9, 2010 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900192
20.
Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.
J Med Chem
; 53(15): 5727-37, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20684608