1.
Toxicol Sci
; 146(1): 11-5, 2015 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26026993
RESUMO
The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.
Assuntos
Disruptores Endócrinos/farmacologia , Sistema Endócrino/efeitos dos fármacos , Disruptores Endócrinos/toxicidade , Humanos , Testes de Toxicidade
2.
Toxicol Sci
; 149(2): 273-4, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27213197