Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Selective thyroid hormone receptor ß agonists with oxadiazolone acid isosteres.
Bioorg Med Chem Lett
; 30(21): 127465, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32768645
3.
Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
Mol Pharm
; 12(11): 3986-98, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26393951
4.
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
Gastroenterology
; 144(7): 1508-17, 1517.e1-10, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23415804
5.
Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses.
J Pharmacol Exp Ther
; 348(1): 96-105, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24133297
6.
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
J Med Chem
; 63(10): 5031-5073, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31930920
7.
Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha.
Nucleic Acids Res
; 33(8): 2620-8, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15879351
8.
Synthesis of an isostere of an O-linked glycopeptide.
Org Lett
; 6(19): 3221-4, 2004 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15355017
9.
A new method for the stereoselective synthesis of alpha-substituted serine amino acid analogues.
Org Lett
; 5(22): 4017-20, 2003 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-14572238
10.
Convergent enantioselective synthesis of the tricyclic core of phomactin A.
Org Lett
; 4(14): 2413-6, 2002 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12098260
11.
Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.
J Med Chem
; 56(18): 7324-33, 2013 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23961878
12.
Application of serine- and threonine-derived cyclic sulfamidates for the preparation of S-linked glycosyl amino acids in solution- and solid-phase peptide synthesis.
J Am Chem Soc
; 124(11): 2534-43, 2002 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-11890803
13.
Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization.
J Am Chem Soc
; 125(7): 1712-3, 2003 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12580592
14.
Stereoselective synthesis of conformationally constrained glycosylated amino acids using an enzyme-catalyzed desymmetrization.
J Org Chem
; 68(4): 1348-57, 2003 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12585874
15.
Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.
Bioorg Med Chem Lett
; 13(2): 301-4, 2003 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12482445