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PLoS Comput Biol ; 11(7): e1004274, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26158448

RESUMO

In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides detailed tracking of samples and data coupled with reliable and repeatable analysis pipelines. The GMS also serves as a platform for bioinformatics development, allowing a large team to collaborate on data analysis, or an individual researcher to leverage the work of others effectively within its data management system. Rather than separating ad-hoc analysis from rigorous, reproducible pipelines, the GMS promotes systematic integration between the two. As a demonstration of the GMS, we performed an integrated analysis of whole genome, exome and transcriptome sequencing data from a breast cancer cell line (HCC1395) and matched lymphoblastoid line (HCC1395BL). These data are available for users to test the software, complete tutorials and develop novel GMS pipeline configurations. The GMS is available at https://github.com/genome/gms.


Assuntos
Mapeamento Cromossômico/métodos , Genoma Humano/genética , Bases de Conhecimento , Modelos Genéticos , Análise de Sequência de DNA/métodos , Interface Usuário-Computador , Algoritmos , Simulação por Computador , Sistemas de Gerenciamento de Base de Dados , Bases de Dados Genéticas , Humanos , Alinhamento de Sequência/métodos
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