Detalhe da pesquisa
1.
ß-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Cell
; 181(6): 1364-1379.e14, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32470395
2.
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Antimicrob Agents Chemother
; 66(4): e0210921, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266827
3.
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat Chem Biol
; 13(6): 624-632, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346406
4.
Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.
J Biol Chem
; 289(11): 7825-34, 2014 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24500713
5.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
6.
Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein.
SLAS Discov
; 27(8): 448-459, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36210051
7.
Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
J Med Chem
; 64(9): 5645-5653, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33914534
8.
Discovery of ß-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
J Med Chem
; 62(17): 8357-8363, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31390201
9.
Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC.
J Thorac Oncol
; 14(12): 2152-2163, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31470128
10.
N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.
ChemMedChem
; 11(3): 283-8, 2016 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26693836
11.
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
ACS Chem Biol
; 11(7): 1880-90, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27119457
12.
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
J Med Chem
; 48(6): 1849-56, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771430
13.
Connecting proteins with drug-like compounds: Open source drug discovery workflows with BindingDB and KNIME.
Database (Oxford)
; 20152015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26384374
14.
Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.
ChemMedChem
; 10(10): 1655-71, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26286375
15.
Discovery of ML314, a Brain Penetrant Non-Peptidic ß-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
ACS Med Chem Lett
; 4(9): 846-851, 2013 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24611085
16.
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.
ACS Chem Neurosci
; 3(3): 221-236, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22737280
17.
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
J Med Chem
; 55(16): 7262-72, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22813531
18.
Multidrug resistance reversal activity of key ningalin analogues.
Bioorg Med Chem Lett
; 13(10): 1777-81, 2003 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12729663
19.
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Bioorg Med Chem
; 11(17): 3815-38, 2003 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12901927
20.
Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Bioorg Med Chem
; 11(20): 4487-501, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-13129585