Detalhe da pesquisa
1.
Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Chimia (Aarau)
; 71(10): 722-729, 2017 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29070417
2.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
3.
Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Bioorg Med Chem Lett
; 25(9): 1884-91, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25838147
4.
UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.
J Biol Chem
; 288(31): 22576-83, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754276
5.
Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Bioorg Med Chem Lett
; 24(4): 1201-8, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24447850
6.
Identification of a new chemical class of antimalarials.
J Infect Dis
; 206(5): 735-43, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22732921
7.
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.
ChemMedChem
; 15(23): 2286-2305, 2020 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32937014
8.
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved inâ vivo Efficacy in Dogs.
ChemMedChem
; 15(5): 430-448, 2020 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31945272
9.
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
ChemMedChem
; 14(13): 1257-1270, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31066976
10.
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
J Med Chem
; 60(23): 9769-9789, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29116786
11.
Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
ChemMedChem
; 11(19): 2132-2146, 2016 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27390287
12.
Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.
ChemMedChem
; 11(18): 1995-2014, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27471138
13.
Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
ChemMedChem
; 9(11): 2486-96, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25147058