Detalhe da pesquisa
1.
Multi-chamber cardioids unravel human heart development and cardiac defects.
Cell
; 186(25): 5587-5605.e27, 2023 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38029745
2.
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity.
Cell
; 168(1-2): 86-100.e15, 2017 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27916275
3.
Apo2ph4: A Versatile Workflow for the Generation of Receptor-based Pharmacophore Models for Virtual Screening.
J Chem Inf Model
; 63(1): 101-110, 2023 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36526584
4.
Clerodane Diterpenes from Casearia corymbosa as Allosteric GABAA Receptor Modulators.
J Nat Prod
; 85(5): 1201-1210, 2022 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35475609
5.
Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies.
J Nat Prod
; 82(4): 823-831, 2019 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30840453
6.
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.
Pharmacol Res
; 131: 150-163, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29477480
7.
Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation.
Pflugers Arch
; 469(11): 1485-1493, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28766141
8.
HPLC-Based Activity Profiling for GABAA Receptor Modulators in Searsia pyroides Using a Larval Zebrafish Locomotor Assay.
Planta Med
; 83(14-15): 1169-1175, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28511229
9.
Upward movement of IS4 and IIIS4 is a rate-limiting stage in Cav1.2 activation.
Pflugers Arch
; 468(11-12): 1895-1907, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27796578
10.
hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico - In Vitro Screening.
Planta Med
; 82(11-12): 1009-15, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145237
11.
Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes.
Org Biomol Chem
; 13(4): 990-4, 2015 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25438036
12.
Nitrogenated honokiol derivatives allosterically modulate GABAA receptors and act as strong partial agonists.
Bioorg Med Chem
; 23(20): 6757-62, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26410663
13.
hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala.
J Nat Prod
; 78(7): 1697-707, 2015 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26091146
14.
HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana.
Planta Med
; 81(12-13): 1154-62, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25922911
15.
A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice.
J Pharmacol Exp Ther
; 351(2): 234-42, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25161170
16.
Structural insights into trapping and dissociation of small molecules in K⺠channels.
J Chem Inf Model
; 54(11): 3218-28, 2014 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25297379
17.
Experimentally validated HERG pharmacophore models as cardiotoxicity prediction tools.
J Chem Inf Model
; 54(10): 2887-901, 2014 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25148533
18.
Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators.
Bioorg Med Chem
; 22(4): 1276-84, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24462176
19.
HPLC-based activity profiling for GABAA receptor modulators in Adenocarpus cincinnatus.
J Nat Prod
; 77(3): 640-9, 2014 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24571311
20.
Natural products as potential human ether-a-go-go-related gene channel inhibitors - outcomes from a screening of widely used herbal medicines and edible plants.
Planta Med
; 80(12): 1045-50, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25089737