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BACKGROUND: Noncompliance with evidence-based interventions and guidelines contributes to significant and variable recurrence and progression in patients with non-muscle-invasive bladder cancer (NMIBC). The implementation of a quality performance indicator (QPI) programme in Scotland's National Health Service (NHS) aimed to improve cancer outcomes and reduce nationwide variance. OBJECTIVE: To evaluate the effect of hospitals achieving benchmarks for two specific QPIs on time to recurrence and progression in NMIBC. DESIGN, SETTING, AND PARTICIPANTS: QPIs for bladder cancer (BC) were enforced nationally in April 2014. NHS health boards collected prospective data on all new BC patients. Prospectively recorded surveillance data were pooled from 12 collaborating centres. INTERVENTION: QPIs of interest were (1) hospitals achieving detrusor muscle (DM) sampling target at initial transurethral resection of bladder tumour (TURBT) and (2) use of single instillation of mitomycin C after TURBT (SI-MMC). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary and secondary endpoints were time to recurrence and progression, respectively. Kaplan-Meier and Cox multivariable regression analyses were performed. KEY FINDINGS AND LIMITATIONS: Between April 1, 2014 and March 31, 2017, we diagnosed 3899 patients with new BC, of which 2688 were NMIBC . With a median follow up of 60.3 mo, hospitals achieving the DM sampling target had a 5.4% lower recurrence rate at 5 yr than hospitals not achieving this target (442/1136 [38.9%] vs 677/1528 [44.3%], 95% confidence interval [CI] = 1.6-9.2, p = 0.005). SI-MMC was associated with a 20.4% lower recurrence rate (634/1791 [35.4%] vs 469/840 [55.8%], 95% CI = 16.4-24.5, p < 0.001). On Cox multivariable regression, meeting the DM target and SI-MMC were associated with significant improvement in recurrence (hazard ratio [HR] 0.81, 95% CI = 0.73-0.91, p = 0.0002 and HR 0.66, 95% CI = 0.59-0.74, p < 0.004, respectively) as well as progression-free survival (HR 0.62, 95% CI = 0.45-0.84, p = 0.002 and HR 0.65, 95% CI = 0.49-0.87, p = 0.004, respectively). We did not have a national multicentre pre-QPI control. CONCLUSIONS: Within a national QPI programme, meeting targets for sampling DM and SI-MMC in the real world were independently associated with delays to recurrence and progression in NMIBC patients. PATIENT SUMMARY: Following the first 3 yr of implementing a novel quality performance indicator programme in Scotland, we evaluated compliance and outcomes in non-muscle-invasive bladder cancer. In 2688 patients followed up for 5 yr, we found that achieving targets for sampling detrusor muscle and the single instillation of mitomycin C during and after transurethral resection of bladder tumour, respectively, were associated with delays in cancer recurrence and progression.
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BACKGROUND: Clinical outcomes from non-muscle-invasive bladder cancer (NMIBC) are partly determined by the quality of initial interventions. To improve and standardise treatment for cancer, Scotland implemented a national Quality Performance Indicator (QPI) programme for bladder cancer (BC). OBJECTIVE: To evaluate compliance with specific quality indicators (QIs) related to transurethral resection of bladder tumour (TURBT) and to understand clinical outcomes from NMIBC following the introduction of the QPI programme. DESIGN, SETTING, AND PARTICIPANTS: Within a robust governance framework, 12 mandatory evidence-based QPIs were implemented nationally in April 2014. We report prospectively collected data for all new BC patients (between April 2014 and March 2017). We include follow-up data for 2689 patients. INTERVENTION: The TURBT-related QPIs were (1) using a bladder diagram, (2) single post-TURBT instillation of mitomycin C (SPI-MMC), (3) detrusor muscle (DM) in the specimen, and (4) early re-TURBT in high-risk NMIBC. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We measured compliance with these QPIs and (1) recurrence rate at first follow-up cystoscopy (RRFFC), (2) rates of residual cancer, and (3) pT2 cancer at re-TURBT. Associations between QPI compliance, tumour features, and outcomes were assessed with multivariable logistic regression models. RESULTS AND LIMITATIONS: Among 4246 new BC patients, SPI-MMC was used in 67% (2029/3023) NMIBC patients. In 1860 NMIBC patients undergoing TURBT, RRFFC, rate of residual cancer, and rate of pT2 at re-TURBT were 13% (116/888), 33% (212/653), and 2.9% (19/653), respectively. SPI-MMC was associated with lower RRFFC, independent of all variables including hospital volume and surgeon. Presence of DM in the specimen halved the likelihood of residual disease in pT1 cancers. The main limitation is the lack of a pre-QPI introduction cohort for comparison. CONCLUSIONS: The implementation of a QI programme in Scotland appears to facilitate high-quality TURBT, which in a real-world setting is associated with low early recurrence/residual cancer and accurate pathological staging. PATIENT SUMMARY: Following the first 3 yr of implementing a novel Quality Performance Indicator (QPI) programme in Scotland, we assessed compliance and outcomes in non-muscle-invasive bladder cancer. Evaluating over 4000 new bladder cancer patients, we found that the QPI programme was associated with low recurrence and accurate staging following the initial transurethral resection of bladder tumour.
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Cistectomia/métodos , Melhoria de Qualidade , Neoplasias da Bexiga Urinária/tratamento farmacológico , Neoplasias da Bexiga Urinária/cirurgia , Administração Intravesical , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibióticos Antineoplásicos/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mitomicina/administração & dosagem , Invasividade Neoplásica , Estudos Prospectivos , Indicadores de Qualidade em Assistência à Saúde , Escócia , Resultado do Tratamento , Uretra , Neoplasias da Bexiga Urinária/patologia , Adulto JovemRESUMO
INTRODUCTION: The impact of a urology oncology nurse specialist in the practice environment to assist with both pre and postoperative education needs of men undergoing genitourinary surgery for cancer was evaluated. OBJECTIVE: This study aimed to improve the preoperative process and teaching for men planning surgery for genitourinary cancers, including the delivery of pathology results. A secondary aim was to decrease the incidence of postoperative incontinence. METHODS: Male patients undergoing a radical prostatectomy were recruited. Patients who underwent surgery were evaluated both before and after the urology oncology nurse specialist role was established. Followup was via phone call interview and International Prostate Symptom Score questionnaire. RESULTS: Men who received the personalized education from the urology oncology nurse specialist had a higher return of continence postoperatively, as well as higher satisfaction scores with the outcome of their surgery, including higher quality of life scores. CONCLUSION: The urology oncology nurse specialist role had a significant impact on the postoperative incontinence rate and provided a missing patient education piece that improved the overall patient satisfaction rate with oncology-related care.
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Enfermeiros Clínicos/organização & administração , Educação de Pacientes como Assunto/organização & administração , Prostatectomia/efeitos adversos , Incontinência Urinária/prevenção & controle , Seguimentos , Humanos , Incidência , Masculino , Papel do Profissional de Enfermagem , Auditoria de Enfermagem , Pesquisa em Avaliação de Enfermagem , Satisfação do Paciente , Assistência Perioperatória/enfermagem , Assistência Perioperatória/psicologia , Avaliação de Programas e Projetos de Saúde , Prostatectomia/enfermagem , Prostatectomia/psicologia , Qualidade de Vida , Índice de Gravidade de Doença , Inquéritos e Questionários , Gestão da Qualidade Total/organização & administração , Incontinência Urinária/epidemiologia , Incontinência Urinária/etiologia , UrodinâmicaRESUMO
People with cancer in the UK should have access to a full spectrum of services. The role of the clinical nurse specialist is an important part of this development. In the specialty of urology/oncology, this role is still a relatively new development although the incidence of urological malignancy readily compares with other site-specific cancers.
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Auditoria de Enfermagem , Especialidades de Enfermagem , Neoplasias Urológicas/enfermagem , Instituições de Assistência Ambulatorial , Humanos , Oncologia , Papel do Profissional de Enfermagem , Satisfação do Paciente , Desenvolvimento de Programas , UrologiaRESUMO
Prostate cancer is the most frequently diagnosed malignancy among UK men and accounts for 12% of male deaths. Androgen deprivation therapy (ADT) is commonly used as part of the treatment for prostate cancer. It is effective at suppressing prostate-specific antigen, stabilizing disease, alleviating symptoms in advanced disease, and potentially prolonging survival. However ADT, presumably at least in part owing to low testosterone levels is associated with insulin resistance, the development of metabolic syndrome plus increased overall and cardiovascular disease mortality. We have reviewed the relationship between prostate cancer, ADT, metabolic syndrome, type 2 diabetes, and cardiovascular disease. We have not reviewed other potential medical problems such as osteoporosis. We suggest that there should be a baseline assessment of patients' risk for cardiovascular disease before starting ADT. Consideration should be given to starting appropriate therapies including lifestyle advice, antihypertensive and lipid-lowering agents, insulin sensitizer, plus possibly aspirin. Having started ADT, the patients should have a regular (possibly annual) assessment of their cardiovascular risk factors.
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Antagonistas de Androgênios/efeitos adversos , Doenças Cardiovasculares/induzido quimicamente , Complicações do Diabetes/induzido quimicamente , Diabetes Mellitus Tipo 2/fisiopatologia , Síndrome Metabólica/induzido quimicamente , Obesidade/induzido quimicamente , Neoplasias da Próstata/tratamento farmacológico , Doenças Cardiovasculares/mortalidade , Complicações do Diabetes/mortalidade , Humanos , Masculino , Síndrome Metabólica/mortalidade , Obesidade/mortalidade , Neoplasias da Próstata/complicações , Medição de Risco , Fatores de Risco , Taxa de SobrevidaRESUMO
INTRODUCTION: The obstructed, infected kidney is a urological emergency. It has been accepted that the management of infected hydronephrosis secondary to ureteric stones is through prompt decompression of the collecting system. However, the optimal method of decompression has yet to be established. MATERIALS AND METHODS: A PubMed and Medline search was performed of all English-language articles from 1960 using key words "sepsis," "urosepsis," "obstruction," "obstructive pyelonephritis," "pyonephrosis," "infection and hydronephrosis" "decompression," "stent," "nephrostomy," and "management." The Cochrane database and National Institute for Clinical Effectiveness guidelines were searched using the terms "sepsis," "urosepsis," "stent," "nephrostomy," or "obstruction." Scottish intercollegiate guidelines were reviewed and no relevant guidance was identified. RESULTS: Two randomised trials have compared retrograde stent insertion with percutaneous nephrostomy with one trial reporting specifically on patients with acute sepsis and obstruction. Neither trial showed one superior modality of decompression in effecting decompression and resolution of sepsis. A further literature search regarding the complications of percutaneous nephrostomy and stent insertion was carried out. An overall major complication rate from percutaneous nephrostomy insertion was found to be 4%, although the complication rates from stent insertion are less consistently reported. DISCUSSION: There appears little evidence to suggest that retrograde stent insertion leads to increased bacteraemia or is significantly more hazardous in the setting of acute obstruction. Further region-wide discussion between urologists and interventional radiologists is required to establish management protocols for these acutely unwell patients.
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Drenagem , Medicina Baseada em Evidências , Pionefrose/etiologia , Pionefrose/cirurgia , Cálculos Ureterais/complicações , Cálculos Ureterais/cirurgia , Descompressão Cirúrgica , Humanos , Nefrostomia Percutânea/efeitos adversos , Ensaios Clínicos Controlados Aleatórios como Assunto , Stents/efeitos adversosRESUMO
OBJECTIVES: To evaluate the success of implementing a day-surgery admission policy for pyelolithotomy and pyeloplasty in pediatric cases. METHODS: A retrospective audit of the urology day-surgery unit records was performed for the period of January 1994 to December 1998. The data included the number of patients and their sex, type of procedures performed, the criteria for case selection, and reported complications that required readmission. The mean patient age was 2.6 years. The decision to perform these procedures on a day-surgery basis was taken after completing preoperative investigations and making the decision for surgery. Several criteria were developed to ensure the success of this application. The parents' understanding of the day surgery concept was the most important criterion. Pyeloplasties were performed using the Anderson-Hynes technique without stenting and were performed only for patients with an extrarenal pelvis. Pain control was delivered through wound infiltration with long-acting local anesthetic followed by oral non-narcotic analgesics. The immediate follow-up period was 4 to 5 weeks postoperatively, and long-term follow-up data were available for 2.5 to 3 years. RESULTS: During the study period, 209 patients underwent surgery for pelviureteral junction obstruction repair and 305 underwent pyelolithotomy for renal stones. Of these children, 85% were discharged the same day, with no reported readmissions during the immediate or delayed follow-up period. CONCLUSIONS: The results of this study have demonstrated that day surgery can be safely used for children requiring open renal surgical procedures that have more traditionally been performed on an inpatient basis. This has considerable resource implications at little cost in terms of patient morbidity.