Detalhe da pesquisa
1.
ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer.
BMC Cancer
; 22(1): 1107, 2022 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36309653
2.
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor ß Superfamily Type 1 Receptors.
Mol Pharmacol
; 95(2): 222-234, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30459156
3.
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.
Br J Cancer
; 119(10): 1233-1243, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30385821
4.
Delivering manual cardiopulmonary resuscitation (CPR) in a diving bell: an analysis of head-to-chest and knee-to-chest compression techniques.
Diving Hyperb Med
; 53(3): 172-180, 2023 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37718290
5.
An evaluation of the NUI Compact Chest Compression Device (NCCD), a mechanical CPR device suitable for use in the saturation diving environment.
Diving Hyperb Med
; 53(3): 181-188, 2023 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37718291
6.
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Clin Cancer Res
; 27(15): 4353-4366, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011558
7.
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
ACS Med Chem Lett
; 9(8): 809-814, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128072
8.
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
J Med Chem
; 61(9): 3823-3841, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29683659
9.
The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy.
Oncotarget
; 8(67): 110904-110913, 2017 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29340025
10.
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.
Cancer Res
; 62(16): 4645-55, 2002 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12183421
11.
Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models.
Clin Cancer Res
; 8(6): 1974-83, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12060643