Detalhe da pesquisa
1.
Activation of human STING by a molecular glue-like compound.
Nat Chem Biol
; 20(3): 365-372, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37828400
2.
Compound Activity Prediction with Dose-Dependent Transcriptomic Profiles and Deep Learning.
J Chem Inf Model
; 64(7): 2695-2704, 2024 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293736
3.
Discovery of a ZIP7 inhibitor from a Notch pathway screen.
Nat Chem Biol
; 15(2): 179-188, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30643281
4.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Nature
; 512(7512): 49-53, 2014 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043012
5.
Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition.
Nucleic Acids Res
; 46(18): 9309-9320, 2018 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30215772
6.
Large-scale prediction and testing of drug activity on side-effect targets.
Nature
; 486(7403): 361-7, 2012 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22722194
7.
Ten simple rules to power drug discovery with data science.
PLoS Comput Biol
; 16(8): e1008126, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32853229
8.
Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening.
J Chem Inf Model
; 56(9): 1622-30, 2016 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27487177
9.
Using information from historical high-throughput screens to predict active compounds.
J Chem Inf Model
; 54(7): 1880-91, 2014 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24933016
10.
Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery.
J Cheminform
; 16(1): 33, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38515171
11.
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical MatterâCompounds with Novel Mechanisms from High-Throughput Screening Profiles.
ACS Chem Biol
; 19(4): 938-952, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38565185
12.
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.
ACS Chem Biol
; 17(6): 1401-1414, 2022 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35508359
13.
Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships.
J Chem Inf Model
; 51(12): 3158-68, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22098146
14.
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.
Dev Cell
; 56(12): 1756-1769.e7, 2021 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34022133
15.
CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
Cell Chem Biol
; 28(10): 1407-1419.e6, 2021 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33794192
16.
Drug discovery: Rethinking cellular drug response.
Nat Chem Biol
; 9(11): 669-70, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24141220
17.
Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Nat Chem Biol
; 4(1): 59-68, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18066055
18.
Systematic Chemogenetic Library Assembly.
Cell Chem Biol
; 27(9): 1124-1129, 2020 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32707038
19.
Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity.
J Biomol Screen
; 14(6): 690-9, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19531667
20.
Which aspects of HTS are empirically correlated with downstream success?
Curr Opin Drug Discov Devel
; 11(3): 327-37, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18428086