Detalhe da pesquisa
1.
Development of Novel Immunoprophylactic Agents against Multidrug-Resistant Gram-Negative Bacterial Infections.
Antimicrob Agents Chemother
; 65(11): e0098521, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34370589
2.
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(3): 1124-30, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18082401
3.
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(6): 1931-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18294847
4.
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 18(1): 129-36, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032040
5.
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
Bioorg Med Chem Lett
; 18(16): 4503-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18667310
6.
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
Bioorg Med Chem
; 16(10): 5606-18, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18417348
7.
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
J Med Chem
; 50(25): 6356-66, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994683
8.
Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.
J Med Chem
; 50(22): 5249-52, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918824
9.
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(24): 6825-31, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17964151
10.
Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(23): 6546-52, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17933528
11.
Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine.
Org Lett
; 14(8): 2078-81, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22480368
12.
Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(18): 5165-70, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17629702
13.
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.
Bioorg Med Chem
; 15(15): 5166-76, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17544282
14.
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(20): 5610-3, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822895
15.
Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 16(17): 4674-8, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16777413
16.
Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.
Bioorg Med Chem Lett
; 16(14): 3693-6, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697187
17.
Propionylpiperazines as human melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 16(18): 4800-3, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16824757
18.
Practical asymmetric synthesis of alpha-branched 2-piperazinylbenzylamines by 1,2-additions of organometallic reagents to N-tert-butanesulfinyl imines.
J Org Chem
; 70(22): 8924-31, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16238329
19.
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.
Bioorg Med Chem Lett
; 15(19): 4389-95, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16098742
20.
Total synthesis of the ramoplanin A2 and ramoplanose aglycon.
J Am Chem Soc
; 125(7): 1877-87, 2003 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12580615