Detalhe da pesquisa
1.
Small molecule inhibitors of anthrax edema factor.
Bioorg Med Chem Lett
; 28(2): 134-139, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29198864
2.
Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.
Antimicrob Agents Chemother
; 57(9): 4139-45, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23774434
3.
Virtual medicinal chemistry: in silico pre-docking functional group transformation for discovery of novel inhibitors of botulinum toxin serotype A light chain.
Bioorg Med Chem Lett
; 23(9): 2505-11, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23545109
4.
Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives.
Mol Pharmacol
; 81(3): 440-54, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169851
5.
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg Med Chem Lett
; 22(6): 2242-6, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342144
6.
Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.
Biochemistry
; 50(19): 4019-28, 2011 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21434688
7.
Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.
Bioorg Med Chem Lett
; 21(7): 2030-3, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21334206
8.
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.
Bioorg Med Chem Lett
; 20(22): 6850-3, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20864339
9.
Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem Biol
; 12(5): 1211-1216, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28402100
10.
Optimization of Substrate-Analogue Furin Inhibitors.
ChemMedChem
; 12(23): 1953-1968, 2017 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29059503
11.
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Biochem Pharmacol
; 96(2): 107-18, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26003844
12.
Microwave-assisted syntheses of regioisomerically pure bromorhodamine derivatives.
Org Lett
; 5(20): 3675-7, 2003 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-14507202
13.
A blue-to-red energy-transfer thymidine analogue that functions in DNA.
Org Lett
; 6(11): 1701-4, 2004 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15151393
14.
On the stability of furanopyrimidin-2-one bases in oligonucleotides.
Chem Commun (Camb)
; (11): 1304-5, 2004 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15154048
15.
Diastereoselective Epoxidation of Cyclohexene Derivatives by Dioxiranes Generated in Situ. Importance of Steric and Field Effects.
J Org Chem
; 64(5): 1635-1639, 1999 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674230
16.
Small molecule proprotein convertase inhibitors for inhibition of embryo implantation.
PLoS One
; 8(12): e81380, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24324690
17.
Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem Biol
; 12(9): 2474, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28782935
18.
Small molecule pan-dengue and West Nile virus NS3 protease inhibitors.
Antivir Chem Chemother
; 21(5): 209-17, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21566267
19.
Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors.
Bioorg Med Chem Lett
; 16(6): 1527-31, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16386899
20.
Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease.
Bioorg Med Chem Lett
; 16(19): 5183-9, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870442