Detalhe da pesquisa
1.
Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling.
Bioorg Chem
; 143: 107016, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086239
2.
Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer.
Bioorg Chem
; 142: 106952, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37952486
3.
Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion.
Bioorg Chem
; 139: 106728, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37536217
4.
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.
Eur J Med Chem
; 267: 116206, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38350360
5.
Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML.
Eur J Med Chem
; 275: 116539, 2024 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38878515
6.
Genomic insights into a robust gamma-aminobutyric acid-producer Lactobacillus brevis CD0817.
AMB Express
; 9(1): 72, 2019 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127390