Detalhe da pesquisa
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125593
2.
Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester.
Chem Res Toxicol
; 33(1): 191-201, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31566356
3.
Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.
Bioorg Med Chem Lett
; 29(14): 1842-1848, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31109791
4.
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
Bioorg Med Chem Lett
; 25(7): 1592-6, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728416
5.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Nat Commun
; 15(1): 489, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216578
6.
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(2): 466-71, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253441
7.
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(3): 844-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265892
8.
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays.
Bioeng Transl Med
; 8(5): e10542, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693049
9.
Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Biochemistry
; 50(22): 4973-80, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21528914
10.
Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Bioorg Med Chem Lett
; 20(8): 2591-6, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20236824
11.
Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
Bioorg Med Chem Lett
; 19(21): 6032-7, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800786
12.
Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
ACS Med Chem Lett
; 8(2): 221-226, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197316
13.
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat Struct Mol Biol
; 24(7): 570-577, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28581512
14.
Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors.
Eur J Med Chem
; 124: 36-48, 2016 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27560281
15.
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.
ACS Med Chem Lett
; 7(1): 111-6, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819676
16.
Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.
J Med Chem
; 58(22): 8806-17, 2015 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26496070
17.
Recent advances in the development of gamma-secretase inhibitors.
Curr Opin Drug Discov Devel
; 5(4): 513-25, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12197309
18.
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.
J Med Chem
; 45(14): 3143-60, 2002 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12086500
19.
Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.
ACS Med Chem Lett
; 3(11): 892-6, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900404
20.
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.
J Med Chem
; 55(1): 489-502, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22098494