The effectiveness of low-dose and high-dose tranexamic acid in posterior lumbar interbody fusion: a double-blinded, placebo-controlled randomized study.

PURPOSE: Tranexamic acid is a proven drug used for reduction of intraoperative blood loss in spinal surgery. However, optimal dosing considering risk/benefits is not well established owing to the heterogeneity in patient selection and surgical procedures of previous studies. This study aimed to evaluate the effectiveness and safety of various tranexamic acid regimens in reducing perioperative blood loss in single-level posterior lumbar interbody fusion (PLIF). METHODS: Patients were randomly grouped into three different interventions: low-dose tranexamic acid (LD), high-dose tranexamic acid (HD), and placebo-controlled (PC) groups. The HD and LD groups received 10 and 5 mg/kg of bolus loading dose and 2 and 1 mg/kg of continuous infusion until 5 h after surgery, respectively. Data on patient demographics and preoperative and 24-h postoperative laboratory values were collected. Outcome parameters include intraoperative blood loss, 24-h postoperative blood loss, and blood loss during removal of the last drain. RESULTS: Seventy-two patients (mean age 63.3 ± 7.6 years) showed similar baseline characteristics. Intraoperatively, blood loss was reduced by the administration of tranexamic acid (P = 0.04), contributed predominantly by a difference between the LD and HD groups (123 mL; P < 0.01). The 24-h postoperative blood loss was reduced (P < 0.01), contributed predominantly by a difference between the PC and LD groups (144 mL; P = 0.02). During the removal of the last drain, statistical difference was found between the PC and HD groups (125 mL; P = 0.00). No complications or side effects from tranexamic acid use were noted. CONCLUSION: Tranexamic acid administration for single-level PLIF was effective and safe in reducing perioperative blood loss in a dose-dependent manner. An HD regimen comprising 10 mg/kg of bolus loading dose and 2 mg/kg/h of continuous infusion is recommended. LEVEL OF EVIDENCE: Level 1 study according to Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence.

Anterior shoulder instability with engaging Hill-Sachs defects: a comparison of arthroscopic Bankart repair with and without posterior capsulodesis.

PURPOSE: The purpose of this study was to compare the clinical results of isolated arthroscopic Bankart repair and those of arthroscopic Bankart repair with posterior capsulodesis for anterior shoulder instability with engaging Hill-Sachs lesions. METHODS: Thirty-five shoulders that underwent isolated arthroscopic Bankart repair (Bankart group) and 37 shoulders that underwent arthroscopic Bankart repair with posterior capsulodesis (remplissage group) for anterior shoulder instability with engaging Hill-Sachs lesions were evaluated retrospectively. The mean age at the time of the surgery was 26.1 ± 7.0 years in the Bankart group and 24.8 ± 9.0 years in the remplissage group. RESULTS: At the final follow-up, the Rowe and UCLA scores significantly improved in both the Bankart and remplissage groups (P < 0.001, in both groups). The post-operative mean deficit in external rotation at the side was 3° ± 10° in the Bankart group and 8° ± 23° in the remplissage group (P = n.s. and P = 0.044, respectively). There was no decrease in muscle strength in either group. The recurrence rate was 25.7 % in the Bankart group and 5.4 % in the remplissage group (P = 0.022). CONCLUSIONS: Arthroscopic Bankart repair with posterior capsulodesis demonstrated good clinical outcomes with a low recurrence rate in the treatment for anterior shoulder instability with an engaging Hill-Sachs lesion. Although a limitation in external rotation was observed, there was no significant limitation of any other motion and no decrease in muscle strength after the remplissage procedure. Posterior capsulodesis alone for remplissage should be considered as a surgical technique that can replace the conventional method. LEVEL OF EVIDENCE: Case-control study, Level III.

Lateral numbness in the lower leg: An underestimated complication following medial open-wedge high tibial osteotomy.

BACKGROUND: This study aimed to investigate the incidence, degree, and natural course of lateral numbness following medial open-wedge high tibial osteotomy (MOWHTO). It also evaluated which predisposing factors would affect lateral numbness following MOWHTO. METHODS: One-hundred and sixty-nine knees that underwent MOWHTO for treatment of varus osteoarthritis with a minimum follow-up of three years were enrolled. Lateral numbness in the lower leg was assessed with the light-touch method using a cotton wool ball and compared with the contralateral leg. Patients were classified into groups based on a scale according to grading of sensation to light touch. To assess the improvement of lateral numbness, lower leg sensation was investigated using a sensory score compared with the contralateral leg. The predisposing factors that would affect lateral numbness were assessed. RESULTS: Lateral numbness was observed in 87 knees (51.5%) at six weeks postoperatively. Although 69 knees improved over time, 18 knees showed no improvement to the latest follow-up. The level of skin incision showed a significant association with lateral numbness on univariate and multivariate analyses: the higher the level of skin incision, the greater the degree of estimated numbness. CONCLUSIONS: About half the patients reported postoperative lateral numbness in the lower leg following MOWHTO. Of the patients with lateral numbness, approximately one-fifth remained symptom until the last follow-up. The level of skin incision might be a risk factor for lateral numbness. Pre-operative patient education concerning the likelihood of lateral numbness is recommended. LEVEL OF EVIDENCE: Level IV, case series.

Supra-acetabular line is better than supra-iliac line for coronal balance referencing-a study of perioperative whole spine X-rays in degenerative lumbar scoliosis and ankylosing spondylitis patients.

BACKGROUND CONTEXT: The aim of spinal deformity correction is to restore the spine's functional alignment by balancing it in both the sagittal and coronal planes. Regardless of posture, the ideal coronal profile is straight, and therefore readily assessable. PURPOSE: This study compares two radiological methods to determine which better predicts postoperative standing coronal balance. STUDY DESIGN/SETTING: We conducted a single-center, radiographic comparative study between 2011 and 2015. PATIENT SAMPLE: A total of 199 patients with a mean age of 55.1 years were studied. Ninety patients with degenerative lumbar scoliosis (DLS) and 109 ankylosing spondylitis (AS) were treated with posterior surgery during this period. OUTCOME MEASURES: Baseline clinical and radiographic parameters (sagittal and coronal) were recorded. Comparison was performed between the new supra-acetabular line (central sacral vertical line [CSVL1]) and conventional supra-iliac line (CSVL2) perpendicular methods of coronal balance assessment. These methods were also compared with the gold standard standing C7 plumb line. METHODS: Each patient underwent standardized operative procedures and had perioperative spine X-rays obtained for assessment of spinal balance. Adjusted multivariate analysis was used to determine predictors of coronal balance. RESULTS: Significant differences in baseline characteristics (age, gender, and radiographic parameters) were found between patients with DLS and AS. CSVL1, CSVL2, and C7 plumb line differed in all the perioperative measurements. These three radiological methods showed a mean right coronal imbalance for both diagnoses in all pre-, intra-, and postoperative radiographs. The magnitude of imbalance was the greatest for CSVL2 followed by CSVL1 and subsequently the C7 plumb line. A larger discrepancy between CSVL and C7 plumb line measurements intraoperatively than those postoperatively suggests a postural effect on these parameters, which is greater for CSVL2. Multivariate analysis identified that in DLS, the preoperative C7 plumb line was predictive of its postoperative value. CSVL1, but not CSVL2, was predictive of the postoperative C7 plumb line in patients with AS. CONCLUSIONS: The supra-acetabular line (CSVL1) is better, although not ideal, as compared with the supra-iliac line (CSVL2) in determining coronal balance. Because CSVL1 still cannot be relied on with a high predictive value, it is imperative that future studies continue to identify better intraoperative markers for achieving coronal balance.

Outcomes and Related Factors of C5 Palsy Following Cervical Laminectomy With Instrumented Fusion Compared With Laminoplasty.

STUDY DESIGN: A retrospective study. OBJECTIVE: The aim of this study was to analyze the clinical outcomes and related factors of C5 palsy (C5P) following posterior cervical laminectomy with fusion (LF) compared with laminoplasty (LP). SUMMARY OF BACKGROUND DATA: C5P is more common after LF than after LP. There have not been any studies on C5P-LF compared with C5P-LP. METHODS: We retrospectively analyzed consecutive cases that underwent cervical LF for nontraumatic cervical myelopathy or myeloradiculopathy (CMR). To analyze the related factors, C5P-LF and non-C5P-LF groups were compared. To assess the clinical parameters, preoperative diagnosis, clinical symptoms, surgical procedures, and outcome instruments were analyzed. Radiographically, we analyzed preoperative maximal spinal cord compression ratio, presence of C4-5 foraminal stenosis (FS), and correction angles on the sagittal plane. To compare with C5P-LP, we analyzed the incidence, time of onset, grade of muscle weakness, other accompanying cervical nerve root palsies, recovery time, and degree of final recovery in the C5P-LF and the C5P-LP groups of 100 consecutive LPs. RESULTS: A total of 90 LF patients were enrolled (M:F = 54:36, mean age 61.1 yr, mean follow-up 35 months). C5P occurred in 26 patients (28.9%), and 14 cases (53.8%) demonstrated other cervical nerve root palsies. Clinically significant differences were observed between the C5P-LF and non-C5P-LF groups with regard to preoperative clinical diagnosis (CMR 88.5:42.2%, P < 0.001) and presence of preoperative upper extremity weakness (57.7:32.3%, P = 0.02). Comparison between the C5P-LF and C5P-LP groups showed significant differences between incidence (28.9:4%), mean grade of weakness (2.1:3.5), accompanying nerve root symptoms (53.8:0%), recovery time (20.8:10.5 weeks), and incidence of incomplete recovery (15.4:0%). CONCLUSION: C5P-LF patients showed higher incidence, more severe weakness, frequent involvement of multiple cervical nerve roots, and longer recovery time than C5P-LP patients. Preoperative clinical manifestation of CMR and preexisting upper extremity weakness were the related factors of C5 palsy. LEVEL OF EVIDENCE: 3.

Fracture of Fully-coated Femoral Stem after Primary Total Hip Arthroplasty for Nonunion of Intertrochanteric Fracture: A Case Report.

Femoral stem fracture is an uncommon reason for the failure of total hip arthroplasty, with only 16 cases of fully coated stem fractures reported to date. Here we report a case in which a fully coated primary femoral stem fracture occurred after conversion to total hip arthroplasty for the non-union of an intertrochanteric fracture of the femur. Metallurgic evaluation of the etiology and mechanism revealed that the fracture was initiated by fatigue-related failure and completed by ductile failure on the posterior side of the fracture. Considering the recent trend of treating an intertrochanteric fracture with hip arthroplasty, possible stem failure should be considered, since most patients will have at least one of the known risk factors for stem fracture.