Detalhe da pesquisa
1.
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.
Toxicol Appl Pharmacol
; 372: 40-46, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30978400
2.
Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.
Chemistry
; 25(16): 4100-4114, 2019 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458057
3.
Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28396548
4.
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity.
Proc Natl Acad Sci U S A
; 110(43): 17564-9, 2013 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24101497
5.
Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.
J Biol Chem
; 286(34): 29718-24, 2011 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730071
6.
Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity.
Mol Cancer Ther
; 21(6): 948-959, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35405741
7.
Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.
J Med Chem
; 64(1): 845-860, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33399453
8.
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Toxicol Lett
; 321: 83-89, 2020 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31863869
9.
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.
PLoS Negl Trop Dis
; 14(4): e0008224, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302296
10.
Discovery of AB680: A Potent and Selective Inhibitor of CD73.
J Med Chem
; 63(20): 11448-11468, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32614585
11.
Identification of a new endogenous metabolite and the characterization of its protein interactions through an immobilization approach.
J Am Chem Soc
; 131(1): 378-86, 2009 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19055353
12.
Efficient synthesis of 2-substituted-1,2,3-triazoles.
Org Lett
; 10(15): 3171-4, 2008 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18597477
13.
Search of nature of planar chirality for pendent benzodiazacoronands in the solid state: NMR, X-ray, and DFT studies.
J Phys Chem B
; 111(11): 2790-9, 2007 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17316041
14.
Nonquaternary reactivators for organophosphate-inhibited cholinesterases.
J Med Chem
; 55(1): 465-74, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22206546
15.
Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response.
J Med Chem
; 55(2): 697-708, 2012 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22191557
16.
Amidine-oximes: reactivators for organophosphate exposure.
J Med Chem
; 54(9): 3319-30, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21438612
17.
Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase.
Chem Biol Interact
; 187(1-3): 163-6, 2010 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20412789
18.
Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.
Chem Biol Interact
; 187(1-3): 238-40, 2010 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20382137
19.
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
J Med Chem
; 52(13): 4038-53, 2009 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19480409
20.
Correlating the transcriptome, proteome, and metabolome in the environmental adaptation of a hyperthermophile.
J Proteome Res
; 7(3): 1027-35, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18247545