Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
Histopathology ; 81(1): 55-64, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35403270

RESUMO

AIMS: To evaluate the frequency, subcellular localization, and variability of CD30 expression in mycosis fungoides. METHODS: This retrospective multicenter study investigated 135 biopsy specimens of 95 patients with mycosis fungoides for CD30 expression and CD30 staining pattern in relation to histomorphologic criteria, eosinophils, and tumour stage. We used two different CD30 cutoffs: (i) any CD30 positivity (important for in-label treatment with an anti-CD30 antibody-based drug), and (ii) ≥10% (most commonly used cutoff in therapy studies). The histologic slides were digitally evaluated with a slide viewer. None of the patients were treated with an anti-CD30 antibody-based drug. RESULTS: We found any CD30 expression in 90% of the samples (tumour cells and tumour microenvironment). More than 60% of the samples had CD30 expression ≥10%. CD30 staining was predominantly cytoplasmic and membranous, a Golgi pattern was only found in three samples. In patients with multiple biopsies (69 samples), a highly variable CD30 expression was found, especially in biopsies taken at different timepoints. CD30 and eosinophils were more common in advanced disease stage and cytoplasmic CD30 staining in intraepidermal lymphocytes was significantly associated with the presence of eosinophils. CONCLUSIONS: 90% of mycosis fungoides biopsies showed CD30 expression and are principally eligible for anti-CD30-antibody treatment. Because of the high intraindividual variability, investigation of multiple tissue samples for CD30 expression improves the assessment of this therapeutic target. Analysis of only a single skin biopsy might lead to misinterpretation of CD30 and bears the risk of inadequate and potentially unfavourable therapeutic decisions.


Assuntos
Imunoconjugados , Micose Fungoide , Neoplasias Cutâneas , Brentuximab Vedotin , Humanos , Imunoconjugados/uso terapêutico , Antígeno Ki-1/análise , Micose Fungoide/diagnóstico , Neoplasias Cutâneas/metabolismo , Microambiente Tumoral
2.
J Cutan Pathol ; 48(4): 495-510, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33047376

RESUMO

BACKGROUND: The surface protein CD30 is a therapeutic target of monoclonal antibody therapy. Knowledge of the frequency of CD30 expression and its prognostic relevance is therefore interesting, not only in lymphoproliferative disorders (LPD) but also in solid tumors of the skin. METHODS: A review was completed in PubMed for all published reports of CD30 expression in cutaneous lymphomas, mastocytosis, epithelial tumors and sarcomas from 1982 to April 2019. Only accessible articles in English and German were considered. Entities with an expected CD30 expression, such as CD30-positive LPD, were not evaluated. RESULTS: The electronic research identified 1091 articles and a further 34 articles were obtained from manual bibliographic reference. Overall 91 articles were included that examined CD30 expression in various entities of cutaneous neoplasms and matched the inclusion criteria. CONCLUSION: Apart from cutaneous CD30-positive LPD, the best-studied group for CD30 expression was mycosis fungoides (MF). CD30 positivity was found in 32% of classical (patch and plaque stage) and in 59.4% cases of transformed MF. CD30 was also frequently expressed in cutaneous mastocytosis (96.5%). In solid tumors, some single reports describe CD30 expression by tumor cells, but CD30-reactive lymphocytes were frequently observed in the tumor microenvironment (TME), especially in keratoacanthoma (KA).


Assuntos
Antígeno Ki-1/metabolismo , Linfoma Cutâneo de Células T/metabolismo , Transtornos Linfoproliferativos/metabolismo , Neoplasias Cutâneas/metabolismo , Microambiente Tumoral/imunologia , Carcinoma/metabolismo , Carcinoma/patologia , Humanos , Imunoterapia/métodos , Ceratoacantoma/metabolismo , Ceratoacantoma/patologia , Linfoma Cutâneo de Células T/patologia , Transtornos Linfoproliferativos/patologia , Mastocitose/metabolismo , Mastocitose/patologia , Micose Fungoide/metabolismo , Micose Fungoide/patologia , Prognóstico , Sarcoma/metabolismo , Sarcoma/patologia , Neoplasias Cutâneas/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA